Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 1651592..1652319 Replicon chromosome
Accession NZ_CP026766
Organism Shigella boydii strain 59-248

Toxin (Protein)


Gene name higB Uniprot ID U9ZMR4
Locus tag C1P58_RS08565 Protein ID WP_000550189.1
Coordinates 1652005..1652319 (-) Length 105 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag C1P58_RS08560 Protein ID WP_000560263.1
Coordinates 1651592..1652008 (-) Length 139 a.a.

Genomic Context

C1P58_RS08545C1P58_RS08550C1P58_RS08555C1P58_RS08575C1P58_RS08580C1P58_RS08585C1P58_RS08560C1P58_RS08565C1P58_RS08570
Location: 1646753..1647799 (1047 bp)
Type: Others
Protein ID: WP_000695473.1
Location: 1648265..1649104 (840 bp)
Type: Others
Protein ID: Protein_1619
Location: 1649530..1651547 (2018 bp)
Type: Others
Protein ID: Protein_1620
Location: 1653825..1654328 (504 bp)
Type: Others
Protein ID: WP_001295542.1
Location: 1654405..1655088 (684 bp)
Type: Others
Protein ID: WP_001183037.1
Location: 1655167..1656153 (987 bp)
Type: Others
Protein ID: WP_077897708.1
Location: 1651592..1652008 (417 bp)
Type: Antitoxin
Protein ID: WP_000560263.1
Location: 1652005..1652319 (315 bp)
Type: Toxin
Protein ID: WP_000550189.1
Location: 1652604..1653740 (1137 bp)
Type: Others
Protein ID: WP_073691071.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
C1P58_RS085451646753..1647799+1047WP_000695473.1alpha-glucosidase-
C1P58_RS085501648265..1649104+840Protein_1619alpha-glucosidase-
C1P58_RS085551649530..1651547+2018Protein_1620NADPH-dependent 2,4-dienoyl-CoA reductase-
C1P58_RS085601651592..1652008-417WP_000560263.1type II toxin-antitoxin system antitoxin HigAAntitoxin
C1P58_RS085651652005..1652319-315WP_000550189.1type II toxin-antitoxin system toxin HigBToxin
C1P58_RS085701652604..1653740-1137WP_073691071.123S rRNA (guanine(1835)-N(2))-methyltransferase RlmG-
C1P58_RS085751653825..1654328+504WP_001295542.1M48 family metallopeptidase-
C1P58_RS085801654405..1655088+684WP_001183037.1vancomycin high temperature exclusion protein-
C1P58_RS085851655167..1656153+987WP_077897708.1Gfo/Idh/MocA family oxidoreductase-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, mRNA interferase HigB

(20-92)

Antitoxin

Cro/C1-type helix-turn-helix domain

(84-135)


Sequences

Toxin        


Download         Length: 105 a.a.        Molecular weight: 12103.10 Da        Isoelectric Point: 10.0409

>T95737 WP_000550189.1 NZ_CP026766:c1652319-1652005 [Shigella boydii]
MHLITQKALKDAAEKYPQHKTELVALGNTIAKGYFKKPESLKAVFPSLDNFKYLDKHYVFNVGGNELRVVAMVFFESQKC
YIREVMTHKEYDFFTAVHRTKGKK

Download         Length: 315 bp

>T95737 NZ_CP026766:c1652319-1652005 [Shigella boydii]
ATGCACCTGATAACTCAAAAAGCATTGAAAGATGCTGCGGAAAAATACCCGCAACATAAAACGGAGTTGGTGGCTCTGGG
GAACACGATTGCTAAGGGATATTTCAAAAAACCTGAGTCATTAAAAGCAGTATTCCCATCTCTGGATAACTTCAAATATC
TGGATAAGCATTATGTTTTCAATGTTGGGGGCAATGAATTACGTGTTGTAGCAATGGTCTTTTTTGAATCGCAAAAGTGC
TACATACGTGAAGTTATGACGCATAAAGAATACGATTTCTTTACCGCTGTTCATCGTACTAAGGGGAAAAAATGA

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 14979.42 Da        Isoelectric Point: 4.4547

>AT95737 WP_000560263.1 NZ_CP026766:c1652008-1651592 [Shigella boydii]
MIAIADILQAGEKLTAVAPFLAGIQNEEQYTQALELVDHLLLNDPENPLLDLVCAKITAWEESAPEFAEFNAMAQAMPGG
IAVIRTLMDQYGLTLADLPEIGSKSMVSRVLSGKRKLTLEHAKKLATRFGISPALFID

Download         Length: 417 bp

>AT95737 NZ_CP026766:c1652008-1651592 [Shigella boydii]
ATGATTGCGATTGCCGACATCTTGCAAGCAGGAGAAAAGCTAACTGCGGTGGCACCTTTTCTGGCGGGTATTCAGAACGA
GGAACAATACACCCAGGCGCTGGAACTGGTAGATCATCTGCTGCTCAACGATCCTGAAAACCCCTTGCTGGATCTGGTGT
GTGCCAAAATAACCGCGTGGGAAGAATCAGCGCCCGAATTTGCGGAATTTAATGCCATGGCTCAAGCCATGCCTGGCGGT
ATAGCCGTGATTCGTACCCTTATGGATCAATATGGTTTAACCCTTGCCGATCTGCCGGAAATTGGCAGTAAATCTATGGT
GTCACGCGTTTTGAGCGGGAAGAGGAAATTAACGCTGGAACACGCTAAAAAATTGGCAACGCGATTCGGCATTTCTCCCG
CCTTGTTTATTGATTAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
PDB6KMQ
PDB5IFG
PDB5YCL
PDB6KML

Antitoxin

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Source
ID
Structure
No matching records found

References