Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) hok-sok/-
Location 449389..449614 Replicon chromosome
Accession NZ_CP026766
Organism Shigella boydii strain 59-248

Toxin (Protein)


Gene name hokW Uniprot ID S1ELB5
Locus tag C1P58_RS02455 Protein ID WP_000813254.1
Coordinates 449389..449544 (-) Length 52 a.a.

Antitoxin (RNA)


Gene name sokW
Locus tag -
Coordinates 449556..449614 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C1P58_RS02420 444692..445750 - 1059 WP_134802271.1 site-specific DNA-methyltransferase -
C1P58_RS02425 445858..446098 - 241 Protein_459 hypothetical protein -
C1P58_RS02430 446323..447144 - 822 WP_000762880.1 antitermination protein -
C1P58_RS02435 447141..447515 - 375 WP_000904114.1 RusA family crossover junction endodeoxyribonuclease -
C1P58_RS02440 447528..448574 - 1047 WP_073691454.1 DUF968 domain-containing protein -
C1P58_RS02445 448576..448854 - 279 WP_001515373.1 hypothetical protein -
C1P58_RS02450 448921..449172 - 252 WP_000980987.1 hypothetical protein -
C1P58_RS02455 449389..449544 - 156 WP_000813254.1 type I toxin-antitoxin system toxin HokD Toxin
- 449556..449614 + 59 - - Antitoxin
C1P58_RS02470 450287..450982 + 696 WP_073832089.1 hypothetical protein -
C1P58_RS02475 450995..451648 + 654 WP_077897731.1 class I SAM-dependent methyltransferase -
C1P58_RS02480 451964..452864 - 901 Protein_468 SMEK domain-containing protein -
C1P58_RS02485 453117..453539 - 423 WP_001151218.1 DUF977 family protein -
C1P58_RS02490 453580..454545 - 966 WP_000054487.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 410089..469403 59314


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Hok/gef cell toxic protein

(6-47)


Sequences

Toxin        


Download         Length: 52 a.a.        Molecular weight: 5736.89 Da        Isoelectric Point: 6.1531

>T95734 WP_000813254.1 NZ_CP026766:c449544-449389 [Shigella boydii]
MKQQKAMLIALIVICLTVIVTALVTRKDLCEVRIRTGQTEVAVFTAYEPEE

Download         Length: 156 bp

>T95734 NZ_CP026766:c449544-449389 [Shigella boydii]
ATGAAGCAGCAAAAGGCGATGCTAATCGCCCTGATCGTCATCTGTTTAACCGTCATAGTGACGGCACTGGTAACGAGGAA
AGACCTCTGCGAGGTACGAATCCGAACCGGCCAGACGGAGGTCGCTGTCTTCACAGCTTACGAACCTGAGGAGTAA

Antitoxin


Download         Length: 59 bp

>AT95734 NZ_CP026766:449556-449614 [Shigella boydii]
CCTTGCCTTTCGGCACGTAAGAGGCTAACCTACGTGTGTAGAGCATAGATATGGCCTCA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A4P7TMW0

Antitoxin

Download structure file

References