Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 783264..783766 Replicon chromosome
Accession NZ_CP026762
Organism Shigella boydii strain NCTC 9850

Toxin (Protein)


Gene name yoeB Uniprot ID U9YDH0
Locus tag C1P50_RS04320 Protein ID WP_000767829.1
Coordinates 783512..783766 (+) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID S1Q063
Locus tag C1P50_RS04315 Protein ID WP_001259255.1
Coordinates 783264..783515 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C1P50_RS04290 778442..779509 - 1068 WP_000080093.1 bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB -
C1P50_RS04295 779509..780579 - 1071 WP_062874234.1 histidinol-phosphate transaminase -
C1P50_RS04300 780576..781880 - 1305 WP_021499265.1 histidinol dehydrogenase -
C1P50_RS04305 781886..782785 - 900 WP_000131782.1 ATP phosphoribosyltransferase -
C1P50_RS04310 782931..782981 - 51 WP_001364200.1 his operon leader peptide -
C1P50_RS04315 783264..783515 + 252 WP_001259255.1 YoeB-YefM toxin-antitoxin system antitoxin YefM Antitoxin
C1P50_RS04320 783512..783766 + 255 WP_000767829.1 type II toxin-antitoxin system mRNA interferase toxin YoeB Toxin
C1P50_RS04325 783849..784673 + 825 WP_000754758.1 SDR family oxidoreductase -
C1P50_RS04330 784719..785648 + 930 WP_000803351.1 LysR family transcriptional regulator -
C1P50_RS04335 785863..785925 + 63 WP_010723108.1 membrane protein YoeI -
C1P50_RS04340 785915..787273 + 1359 WP_000019197.1 putrescine/proton symporter PlaP -
C1P50_RS04345 787452..788412 + 961 Protein_802 YeeE/YedE family protein -
C1P50_RS04350 788426..788653 + 228 WP_000985273.1 sulfurtransferase TusA family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(2-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10183.58 Da        Isoelectric Point: 8.0353

>T95696 WP_000767829.1 NZ_CP026762:783512-783766 [Shigella boydii]
VKLIWSEESWDDYLYWQETDKRIVKKINELIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAAC
RYHY

Download         Length: 255 bp

>T95696 NZ_CP026762:783512-783766 [Shigella boydii]
GTGAAACTAATCTGGTCTGAGGAATCATGGGATGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACGCCATTTGAAGGTAAGGGGAAGCCAGAACCCCTGAAACATAATTTGTCAG
GTTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACCGACGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9307.58 Da        Isoelectric Point: 4.7954

>AT95696 WP_001259255.1 NZ_CP026762:783264-783515 [Shigella boydii]
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE

Download         Length: 252 bp

>AT95696 NZ_CP026762:783264-783515 [Shigella boydii]
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTTATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGCTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACAGAAAAGGAC
ATTATTGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6NY6
PDB 2A6S
PDB 6OXA
PDB 2A6R
PDB 4V8X
PDB 6OTR
PDB 6OXI
PDB 2A6Q

Antitoxin

Source ID Structure
PDB 2A6Q
AlphaFold DB A0A7U9LNR0

References