Detailed information of TA system TA095693

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 591511..591736
• Replicon: chromosome
• Accession: NZ_CP026762
• Organism: Shigella boydii strain NCTC 9850

Toxin (Protein)

• Gene name: hokW
• Uniprot ID: S1ELB5
• Locus tag: C1P50_RS03215
• Protein ID: WP_000813254.1
• Coordinates: 591511..591666 (-)
• Length: 52 a.a.

Antitoxin (RNA)

Gene name	sokW
Locus tag	-
Coordinates	591678..591736 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
C1P50_RS03180	586678..588216	-	1539	Protein_579	IS66-like element ISEc22 family transposase	-
C1P50_RS03185	588265..588612	-	348	WP_000612626.1	IS66 family insertion sequence element accessory protein TnpB	-
C1P50_RS03190	588609..588989	-	381	WP_001333468.1	IS66 family insertion sequence hypothetical protein	-
C1P50_RS03195	589344..590471	-	1128	WP_001063816.1	IS110-like element ISSso6 family transposase	-
C1P50_RS03200	590602..591063	-	462	Protein_583	hypothetical protein	-
C1P50_RS03205	591065..591343	-	279	WP_000929754.1	hypothetical protein	-
C1P50_RS03215	591511..591666	-	156	WP_000813254.1	type I toxin-antitoxin system toxin HokD	Toxin
-	591678..591736	+	59	-	-	Antitoxin
C1P50_RS03230	592318..592760	-	443	Protein_586	hypothetical protein	-
C1P50_RS03235	592804..593184	+	381	WP_001333468.1	IS66 family insertion sequence hypothetical protein	-
C1P50_RS03240	593181..593528	+	348	WP_000612626.1	IS66 family insertion sequence element accessory protein TnpB	-
C1P50_RS03245	593577..595115	+	1539	WP_134795351.1	IS66-like element ISEc22 family transposase	-
C1P50_RS03250	595112..595471	+	360	WP_073692993.1	3'-5' exoribonuclease	-
C1P50_RS03255	595530..595733	+	204	WP_000096344.1	DUF4224 domain-containing protein	-
C1P50_RS03260	595733..596088	+	356	Protein_592	integrase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	ipaH9.8	583615..606756	23141
	-	inside	IScluster/Tn	-	-	584314..599392	15078

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (6-47)

Sequences

Toxin

Protein

• Length: 52 a.a.
• Molecular weight: 5736.89 Da
• Isoelectric Point: 6.1531

>T95693 WP_000813254.1 NZ_CP026762:c591666-591511 [Shigella boydii]
MKQQKAMLIALIVICLTVIVTALVTRKDLCEVRIRTGQTEVAVFTAYEPEE

Nucleotide

• Length: 156 bp

>T95693 NZ_CP026762:c591666-591511 [Shigella boydii]
ATGAAGCAGCAAAAGGCGATGTTAATCGCCCTTATCGTCATCTGTTTAACCGTCATAGTGACGGCACTGGTAACGAGGAA
AGACCTCTGCGAGGTACGAATCCGAACCGGCCAGACGGAGGTCGCTGTCTTCACAGCTTACGAACCTGAGGAGTAA

Antitoxin

Nucleotide

• Length: 59 bp

>AT95693 NZ_CP026762:591678-591736 [Shigella boydii]
CCTTGCCTTTCGGCACGTAAGAGGCTAACCTACATGTGTTCAGCATGGATTGAGCCTCA

Structures

Toxin

• AlphaFold DB: A0A4P7TMW0

Antitoxin