Detailed information of TA system TA095650

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): ldrD-agrB/Ldr(toxin)
• Location: 1143438..1143659
• Replicon: chromosome
• Accession: NZ_CP026755
• Organism: Escherichia coli strain AR_0077

Toxin (Protein)

• Gene name: ldrD
• Uniprot ID: A0A229AEQ8
• Locus tag: AM456_RS06760
• Protein ID: WP_000176713.1
• Coordinates: 1143438..1143545 (-)
• Length: 36 a.a.

Antitoxin (RNA)

Gene name	agrB
Locus tag	-
Coordinates	1143593..1143659 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
AM456_RS06735	1139282..1140364	+	1083	WP_000804726.1	peptide chain release factor 1	-
AM456_RS06740	1140364..1141197	+	834	WP_032171150.1	peptide chain release factor N(5)-glutamine methyltransferase	-
AM456_RS06745	1141194..1141586	+	393	WP_000200374.1	invasion regulator SirB2	-
AM456_RS06750	1141590..1142399	+	810	WP_001257044.1	invasion regulator SirB1	-
AM456_RS06755	1142435..1143289	+	855	WP_000811065.1	3-deoxy-8-phosphooctulonate synthase	-
AM456_RS06760	1143438..1143545	-	108	WP_000176713.1	type I toxin-antitoxin system toxin Ldr family protein	Toxin
-	1143593..1143659	+	67	NuclAT_10	-	Antitoxin
-	1143593..1143659	+	67	NuclAT_10	-	Antitoxin
-	1143593..1143659	+	67	NuclAT_10	-	Antitoxin
-	1143593..1143659	+	67	NuclAT_10	-	Antitoxin
-	1143593..1143659	+	67	NuclAT_12	-	Antitoxin
-	1143593..1143659	+	67	NuclAT_12	-	Antitoxin
-	1143593..1143659	+	67	NuclAT_12	-	Antitoxin
-	1143593..1143659	+	67	NuclAT_12	-	Antitoxin
-	1143593..1143659	+	67	NuclAT_14	-	Antitoxin
-	1143593..1143659	+	67	NuclAT_14	-	Antitoxin
-	1143593..1143659	+	67	NuclAT_14	-	Antitoxin
-	1143593..1143659	+	67	NuclAT_14	-	Antitoxin
-	1143593..1143659	+	67	NuclAT_16	-	Antitoxin
-	1143593..1143659	+	67	NuclAT_16	-	Antitoxin
-	1143593..1143659	+	67	NuclAT_16	-	Antitoxin
-	1143593..1143659	+	67	NuclAT_16	-	Antitoxin
-	1143593..1143659	+	67	NuclAT_18	-	Antitoxin
-	1143593..1143659	+	67	NuclAT_18	-	Antitoxin
-	1143593..1143659	+	67	NuclAT_18	-	Antitoxin
-	1143593..1143659	+	67	NuclAT_18	-	Antitoxin
-	1143593..1143659	+	67	NuclAT_20	-	Antitoxin
-	1143593..1143659	+	67	NuclAT_20	-	Antitoxin
-	1143593..1143659	+	67	NuclAT_20	-	Antitoxin
-	1143593..1143659	+	67	NuclAT_20	-	Antitoxin
-	1143595..1143658	+	64	NuclAT_41	-	-
-	1143595..1143658	+	64	NuclAT_41	-	-
-	1143595..1143658	+	64	NuclAT_41	-	-
-	1143595..1143658	+	64	NuclAT_41	-	-
-	1143595..1143658	+	64	NuclAT_43	-	-
-	1143595..1143658	+	64	NuclAT_43	-	-
-	1143595..1143658	+	64	NuclAT_43	-	-
-	1143595..1143658	+	64	NuclAT_43	-	-
-	1143595..1143658	+	64	NuclAT_45	-	-
-	1143595..1143658	+	64	NuclAT_45	-	-
-	1143595..1143658	+	64	NuclAT_45	-	-
-	1143595..1143658	+	64	NuclAT_45	-	-
-	1143595..1143658	+	64	NuclAT_47	-	-
-	1143595..1143658	+	64	NuclAT_47	-	-
-	1143595..1143658	+	64	NuclAT_47	-	-
-	1143595..1143658	+	64	NuclAT_47	-	-
-	1143595..1143658	+	64	NuclAT_49	-	-
-	1143595..1143658	+	64	NuclAT_49	-	-
-	1143595..1143658	+	64	NuclAT_49	-	-
-	1143595..1143658	+	64	NuclAT_49	-	-
AM456_RS06765	1143973..1144080	-	108	WP_000170956.1	type I toxin-antitoxin system toxin Ldr family protein	-
-	1144133..1144194	+	62	NuclAT_40	-	-
-	1144133..1144194	+	62	NuclAT_40	-	-
-	1144133..1144194	+	62	NuclAT_40	-	-
-	1144133..1144194	+	62	NuclAT_40	-	-
-	1144133..1144194	+	62	NuclAT_42	-	-
-	1144133..1144194	+	62	NuclAT_42	-	-
-	1144133..1144194	+	62	NuclAT_42	-	-
-	1144133..1144194	+	62	NuclAT_42	-	-
-	1144133..1144194	+	62	NuclAT_44	-	-
-	1144133..1144194	+	62	NuclAT_44	-	-
-	1144133..1144194	+	62	NuclAT_44	-	-
-	1144133..1144194	+	62	NuclAT_44	-	-
-	1144133..1144194	+	62	NuclAT_46	-	-
-	1144133..1144194	+	62	NuclAT_46	-	-
-	1144133..1144194	+	62	NuclAT_46	-	-
-	1144133..1144194	+	62	NuclAT_46	-	-
-	1144133..1144194	+	62	NuclAT_48	-	-
-	1144133..1144194	+	62	NuclAT_48	-	-
-	1144133..1144194	+	62	NuclAT_48	-	-
-	1144133..1144194	+	62	NuclAT_48	-	-
-	1144133..1144195	+	63	NuclAT_11	-	-
-	1144133..1144195	+	63	NuclAT_11	-	-
-	1144133..1144195	+	63	NuclAT_11	-	-
-	1144133..1144195	+	63	NuclAT_11	-	-
-	1144133..1144195	+	63	NuclAT_13	-	-
-	1144133..1144195	+	63	NuclAT_13	-	-
-	1144133..1144195	+	63	NuclAT_13	-	-
-	1144133..1144195	+	63	NuclAT_13	-	-
-	1144133..1144195	+	63	NuclAT_15	-	-
-	1144133..1144195	+	63	NuclAT_15	-	-
-	1144133..1144195	+	63	NuclAT_15	-	-
-	1144133..1144195	+	63	NuclAT_15	-	-
-	1144133..1144195	+	63	NuclAT_17	-	-
-	1144133..1144195	+	63	NuclAT_17	-	-
-	1144133..1144195	+	63	NuclAT_17	-	-
-	1144133..1144195	+	63	NuclAT_17	-	-
-	1144133..1144195	+	63	NuclAT_19	-	-
-	1144133..1144195	+	63	NuclAT_19	-	-
-	1144133..1144195	+	63	NuclAT_19	-	-
-	1144133..1144195	+	63	NuclAT_19	-	-
-	1144133..1144195	+	63	NuclAT_21	-	-
-	1144133..1144195	+	63	NuclAT_21	-	-
-	1144133..1144195	+	63	NuclAT_21	-	-
-	1144133..1144195	+	63	NuclAT_21	-	-
AM456_RS06770	1144486..1145586	-	1101	WP_032171152.1	sodium-potassium/proton antiporter ChaA	-
AM456_RS06775	1145856..1146086	+	231	WP_001146444.1	putative cation transport regulator ChaB	-
AM456_RS06780	1146244..1146939	+	696	WP_012311798.1	glutathione-specific gamma-glutamylcyclotransferase	-
AM456_RS06785	1146983..1147336	-	354	WP_001169669.1	DsrE/F sulfur relay family protein YchN	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Type I toxin-antitoxin system, toxin Ldr (1-35)

Sequences

Toxin

Protein

• Length: 36 a.a.
• Molecular weight: 4031.79 Da
• Isoelectric Point: 11.4779

>T95650 WP_000176713.1 NZ_CP026755:c1143545-1143438 [Escherichia coli]
MTLTQFAMTFWHDLAAPILAGIITAAIVSWWRNRK

Nucleotide

• Length: 108 bp

>T95650 NZ_CP026755:c1143545-1143438 [Escherichia coli]
ATGACGCTCACGCAGTTTGCCATGACTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA

Antitoxin

Nucleotide

• Length: 67 bp

>AT95650 NZ_CP026755:1143593-1143659 [Escherichia coli]
GTTCTGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTGTACCTCTCAACGTGCGGGGGTTTTCTC

Structures

Toxin

• AlphaFold DB: A0A229AEQ8

Antitoxin