Detailed information of TA system TA095608

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yefM-yoeB (relBE)/YoeB-YefM
• Location: 1719744..1720258
• Replicon: chromosome
• Accession: NZ_CP026730
• Organism: Streptomyces sp. CB09001

Toxin (Protein)

• Gene name: yoeB
• Uniprot ID: -
• Locus tag: C4J65_RS08055
• Protein ID: WP_115741784.1
• Coordinates: 1720004..1720258 (+)
• Length: 85 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: -
• Locus tag: C4J65_RS08050
• Protein ID: WP_115741783.1
• Coordinates: 1719744..1720007 (+)
• Length: 88 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
C4J65_RS08035	1715593..1716456	+	864	WP_115741781.1	phosphatase PAP2 family protein	-
C4J65_RS08040	1716573..1719569	-	2997	WP_115741782.1	bifunctional [glutamine synthetase] adenylyltransferase/[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase	-
C4J65_RS08050	1719744..1720007	+	264	WP_115741783.1	type II toxin-antitoxin system prevent-host-death family antitoxin	Antitoxin
C4J65_RS08055	1720004..1720258	+	255	WP_115741784.1	Txe/YoeB family addiction module toxin	Toxin
C4J65_RS08060	1720343..1720789	+	447	WP_115741785.1	VOC family protein	-
C4J65_RS08065	1720818..1722593	-	1776	WP_115741786.1	NAD+ synthase	-
C4J65_RS08070	1722711..1723337	-	627	WP_115741787.1	DUF305 domain-containing protein	-
C4J65_RS08075	1723334..1724002	-	669	WP_115741788.1	DUF3105 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (5-84)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (2-72)

Sequences

Toxin

Protein

• Length: 85 a.a.
• Molecular weight: 9939.28 Da
• Isoelectric Point: 9.7377

>T95608 WP_115741784.1 NZ_CP026730:1720004-1720258 [Streptomyces sp. CB09001]
VRITFTSHGWEDYVHWAESDRKVTKRINRLIADIARDPFKGVGKPEPLKGDLSGYWSRRIDDTHRLVYKPTDDLLVIVQA
RYHY

Nucleotide

• Length: 255 bp

>T95608 NZ_CP026730:1720004-1720258 [Streptomyces sp. CB09001]
GTGAGGATCACTTTCACGTCCCACGGCTGGGAGGACTACGTCCACTGGGCCGAGAGCGACCGGAAGGTGACCAAGCGGAT
CAACAGACTGATCGCCGACATCGCCCGTGACCCGTTCAAGGGCGTCGGCAAGCCGGAGCCGCTCAAGGGCGACCTGTCCG
GCTACTGGTCACGGCGCATCGACGACACGCACCGTCTTGTGTACAAGCCCACCGATGACCTGCTGGTCATCGTCCAGGCG
CGCTACCACTACTGA

Antitoxin

Protein

• Length: 88 a.a.
• Molecular weight: 9823.92 Da
• Isoelectric Point: 4.8728

>AT95608 WP_115741783.1 NZ_CP026730:1719744-1720007 [Streptomyces sp. CB09001]
MSITASEARQNLFPLIEQVNEDHAPVHITSRKGNAVLMSEEDFTAWTETVHLLRSPRNARRLLDSIAEAESGDARRRELI
DPDAERA

Nucleotide

• Length: 264 bp

>AT95608 NZ_CP026730:1719744-1720007 [Streptomyces sp. CB09001]
ATGTCCATCACCGCCAGCGAAGCCCGTCAGAATCTGTTCCCGCTGATAGAGCAGGTCAACGAGGACCATGCCCCGGTGCA
CATCACCTCCCGCAAGGGGAACGCCGTGCTCATGTCCGAGGAGGACTTCACGGCGTGGACGGAGACGGTGCATCTCCTGC
GCTCGCCGCGGAACGCCCGCCGGCTGCTCGACTCCATCGCGGAGGCCGAGTCGGGCGACGCACGCCGGCGTGAGCTGATC
GACCCGGACGCGGAGCGGGCGTGA