Detailed information of TA system TA095605

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yefM-yoeB (relBE)/YoeB-RelB
• Location: 1384442..1384956
• Replicon: chromosome
• Accession: NZ_CP026729
• Organism: Bifidobacterium catenulatum subsp. kashiwanohense strain APCKJ1

Toxin (Protein)

• Gene name: yoeB
• Uniprot ID: -
• Locus tag: BKKJ1_RS06355
• Protein ID: WP_055054685.1
• Coordinates: 1384442..1384696 (-)
• Length: 85 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: -
• Locus tag: BKKJ1_RS06360
• Protein ID: WP_154303926.1
• Coordinates: 1384696..1384956 (-)
• Length: 87 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
BKKJ1_RS06335	1380418..1380558	-	141	WP_154303923.1	hypothetical protein	-
BKKJ1_RS06340	1380715..1382919	+	2205	WP_154303924.1	type IA DNA topoisomerase	-
BKKJ1_RS06345	1382928..1383278	+	351	WP_154303925.1	helix-turn-helix transcriptional regulator	-
BKKJ1_RS06350	1383345..1384241	+	897	WP_065438748.1	Fic family protein	-
BKKJ1_RS06355	1384442..1384696	-	255	WP_055054685.1	Txe/YoeB family addiction module toxin	Toxin
BKKJ1_RS06360	1384696..1384956	-	261	WP_154303926.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
BKKJ1_RS06365	1385321..1385473	+	153	WP_154303927.1	hypothetical protein	-
BKKJ1_RS06370	1385746..1386063	-	318	WP_065440803.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (3-84)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (4-75)

Sequences

Toxin

Protein

• Length: 85 a.a.
• Molecular weight: 10013.51 Da
• Isoelectric Point: 7.9920

>T95605 WP_055054685.1 NZ_CP026729:c1384696-1384442 [Bifidobacterium catenulatum subsp. kashiwanohense]
IMLRWTDDAWNDYLYWQVQDKKTLKRVNALIRDAMRSPFAGLGKPEPLKWELQGAWSRRIDSANRLVYMIEDGDLCILSV
RDHY

Nucleotide

• Length: 255 bp

>T95605 NZ_CP026729:c1384696-1384442 [Bifidobacterium catenulatum subsp. kashiwanohense]
ATAATGCTGCGTTGGACTGATGACGCGTGGAACGATTACCTGTATTGGCAGGTTCAGGATAAGAAAACCCTCAAGCGGGT
CAACGCGCTGATACGTGATGCGATGCGTTCTCCATTCGCGGGTCTCGGCAAGCCAGAGCCGCTCAAATGGGAACTGCAGG
GTGCGTGGAGCCGCCGCATCGATTCCGCAAACCGCCTGGTATACATGATTGAGGACGGCGACTTGTGCATTCTGTCCGTC
CGTGACCACTATTGA

Antitoxin

Protein

• Length: 87 a.a.
• Molecular weight: 9814.09 Da
• Isoelectric Point: 5.0462

>AT95605 WP_154303926.1 NZ_CP026729:c1384956-1384696 [Bifidobacterium catenulatum subsp. kashiwanohense]
MVTAVAYTNFRKDLKSYLRRVNDDADMLLVTNKDPRDNVVVMSADDYDSLMETLRVYQNPGLFDKVRRGMAQVRSGSTDL
HDLVGE

Nucleotide

• Length: 261 bp

>AT95605 NZ_CP026729:c1384956-1384696 [Bifidobacterium catenulatum subsp. kashiwanohense]
ATGGTCACGGCGGTCGCGTACACCAATTTCCGCAAGGATCTGAAGTCATATCTACGTCGCGTGAACGATGACGCGGATAT
GCTTCTGGTTACCAACAAGGATCCGAGGGACAACGTGGTGGTGATGAGCGCCGACGATTACGATTCGCTTATGGAGACAT
TGCGCGTTTACCAGAATCCCGGATTGTTCGATAAAGTCCGCCGTGGCATGGCACAGGTACGCTCAGGTTCCACCGATTTA
CATGATCTGGTCGGAGAGTGA