Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 941314..941816 Replicon chromosome
Accession NZ_CP026723
Organism Escherichia coli strain 266917_2

Toxin (Protein)


Gene name yoeB Uniprot ID U9YDH0
Locus tag C4R22_RS04920 Protein ID WP_000767829.1
Coordinates 941314..941568 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID -
Locus tag C4R22_RS04925 Protein ID WP_089602088.1
Coordinates 941565..941816 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C4R22_RS04890 936329..936556 - 228 WP_000985273.1 sulfurtransferase TusA family protein -
C4R22_RS04895 936570..937628 - 1059 WP_000492305.1 transport protein YeeE -
C4R22_RS04900 937807..939165 - 1359 WP_000019197.1 putrescine/proton symporter PlaP -
C4R22_RS04905 939155..939217 - 63 WP_010723108.1 membrane protein YoeI -
C4R22_RS04910 939432..940361 - 930 WP_000803360.1 LysR family transcriptional regulator -
C4R22_RS04915 940407..941231 - 825 WP_000754762.1 SDR family oxidoreductase -
C4R22_RS04920 941314..941568 - 255 WP_000767829.1 type II toxin-antitoxin system mRNA interferase toxin YoeB Toxin
C4R22_RS04925 941565..941816 - 252 WP_089602088.1 YoeB-YefM toxin-antitoxin system antitoxin YefM Antitoxin
C4R22_RS04930 942099..942149 + 51 WP_001364200.1 his operon leader peptide -
C4R22_RS04940 942295..943194 + 900 WP_000131782.1 ATP phosphoribosyltransferase -
C4R22_RS04945 943200..944498 + 1299 WP_089602089.1 histidinol dehydrogenase -
C4R22_RS04950 944501..945571 + 1071 WP_000108941.1 histidinol-phosphate transaminase -
C4R22_RS04955 945571..946638 + 1068 WP_000080136.1 bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(2-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10183.58 Da        Isoelectric Point: 8.0353

>T95566 WP_000767829.1 NZ_CP026723:c941568-941314 [Escherichia coli]
VKLIWSEESWDDYLYWQETDKRIVKKINELIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAAC
RYHY

Download         Length: 255 bp

>T95566 NZ_CP026723:c941568-941314 [Escherichia coli]
GTGAAACTAATCTGGTCTGAGGAATCATGGGATGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACGCCATTTGAAGGTAAGGGGAAGCCAGAACCCCTGAAACATAATTTGTCAG
GTTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACCGACGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9333.66 Da        Isoelectric Point: 4.7954

>AT95566 WP_089602088.1 NZ_CP026723:c941816-941565 [Escherichia coli]
MRTISYSEARQNLLATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE

Download         Length: 252 bp

>AT95566 NZ_CP026723:c941816-941565 [Escherichia coli]
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTTGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTTATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGCTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACAGAAAAGGAC
ATTATTGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6NY6
PDB 2A6S
PDB 6OXA
PDB 2A6R
PDB 4V8X
PDB 6OTR
PDB 6OXI
PDB 2A6Q

Antitoxin

Source ID Structure

References