Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 3806..4464 Replicon plasmid unitig_2_pilon
Accession NZ_CP026712
Organism Acinetobacter baumannii strain AR_0063

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag AM442_RS19445 Protein ID WP_000312250.1
Coordinates 3806..4165 (+) Length 120 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag AM442_RS19450 Protein ID WP_001096429.1
Coordinates 4165..4464 (+) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AM442_RS19420 696..1454 - 759 WP_001053127.1 hypothetical protein -
AM442_RS19425 1521..1904 - 384 WP_000654348.1 hypothetical protein -
AM442_RS19430 2043..2741 - 699 WP_000873188.1 hypothetical protein -
AM442_RS19435 2808..2990 - 183 WP_000373385.1 hypothetical protein -
AM442_RS19440 3039..3605 - 567 WP_000710385.1 hypothetical protein -
AM442_RS19445 3806..4165 + 360 WP_000312250.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
AM442_RS19450 4165..4464 + 300 WP_001096429.1 helix-turn-helix transcriptional regulator Antitoxin
AM442_RS19460 5001..5537 - 537 WP_000731978.1 hypothetical protein -
AM442_RS19465 5587..6141 - 555 WP_000790084.1 hypothetical protein -
AM442_RS19470 6161..6379 - 219 WP_001043201.1 hypothetical protein -
AM442_RS19475 6419..7048 - 630 WP_000701004.1 hypothetical protein -
AM442_RS19480 7065..7244 - 180 WP_000387630.1 hypothetical protein -
AM442_RS19485 7220..7792 - 573 WP_000443897.1 hypothetical protein -
AM442_RS19490 7797..8054 - 258 WP_000834290.1 hypothetical protein -
AM442_RS19495 8159..8611 - 453 Protein_14 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid blaOXA-23 - 1..72990 72990


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(14-109)

Antitoxin

HigA2-like, helix-turn-helix domain

(12-88)


Sequences

Toxin        


Download         Length: 120 a.a.        Molecular weight: 13751.62 Da        Isoelectric Point: 4.8212

>T95514 WP_000312250.1 NZ_CP026712:3806-4165 [Acinetobacter baumannii]
MAWDVETTELFDSWLAEQDENAQDKILASLLVLSELGPNLGRPHVDTIKESKYPNMKEIRVQVKGHPIRGFFAFDPERKA
IVLCAGDKKGLNEKAFYKEMIKIADEQYEQYLRDNYGDK

Download         Length: 360 bp

>T95514 NZ_CP026712:3806-4165 [Acinetobacter baumannii]
ATGGCTTGGGATGTAGAAACAACAGAACTTTTTGATTCTTGGTTGGCAGAACAAGATGAAAATGCTCAAGATAAAATCTT
AGCGTCTTTGCTTGTTTTGTCAGAACTGGGGCCAAATCTAGGCCGGCCTCATGTTGATACTATTAAAGAATCAAAATATC
CGAACATGAAAGAGATACGTGTGCAAGTTAAAGGTCATCCGATCCGTGGTTTCTTTGCATTTGATCCAGAACGTAAAGCC
ATTGTTTTGTGTGCTGGAGATAAGAAAGGGCTAAATGAAAAAGCCTTTTATAAAGAAATGATCAAGATTGCAGATGAACA
ATATGAGCAATATTTACGTGATAATTACGGAGATAAATAA

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 11012.93 Da        Isoelectric Point: 10.4856

>AT95514 WP_001096429.1 NZ_CP026712:4165-4464 [Acinetobacter baumannii]
MAKLNDIISKRSPESQQRIKKMANQMLLDINLSNLREELKISQAEIAKNLGVSQAAISKREKLGKDLKISSLKEYVEAMG
GKVRLDVELPNGKHVAISI

Download         Length: 300 bp

>AT95514 NZ_CP026712:4165-4464 [Acinetobacter baumannii]
ATGGCTAAATTAAACGATATAATTTCAAAACGCTCACCTGAAAGCCAACAACGCATCAAGAAAATGGCAAATCAAATGCT
ATTGGATATTAACCTATCGAACCTACGGGAAGAGTTAAAAATATCTCAAGCTGAAATTGCAAAAAATCTAGGTGTAAGCC
AAGCTGCTATTTCAAAACGTGAAAAATTAGGTAAAGATCTTAAGATTTCATCATTAAAAGAATATGTTGAAGCTATGGGT
GGCAAAGTAAGGTTAGATGTTGAGTTACCTAACGGAAAGCATGTTGCTATATCTATTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References