Detailed information of TA system TA095493

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/COG4683-HTH_37
• Location: 32951..33609
• Replicon: plasmid tig00000059_pilon
• Accession: NZ_CP026706
• Organism: Acinetobacter baumannii strain AR_0056

Toxin (Protein)

• Gene name: higB
• Uniprot ID: -
• Locus tag: AM435_RS00905
• Protein ID: WP_000312250.1
• Coordinates: 32951..33310 (+)
• Length: 120 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: AM435_RS00910
• Protein ID: WP_001096429.1
• Coordinates: 33310..33609 (+)
• Length: 100 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
AM435_RS00870	28472..28786	-	315	WP_000708714.1	hypothetical protein	-
AM435_RS00880	29841..30599	-	759	WP_001053127.1	hypothetical protein	-
AM435_RS00885	30666..31049	-	384	WP_000654348.1	hypothetical protein	-
AM435_RS00890	31188..31886	-	699	WP_000873188.1	hypothetical protein	-
AM435_RS00895	31953..32135	-	183	WP_000373385.1	hypothetical protein	-
AM435_RS00900	32184..32750	-	567	WP_000710385.1	hypothetical protein	-
AM435_RS00905	32951..33310	+	360	WP_000312250.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
AM435_RS00910	33310..33609	+	300	WP_001096429.1	helix-turn-helix transcriptional regulator	Antitoxin
AM435_RS00920	34147..34683	-	537	WP_000731978.1	hypothetical protein	-
AM435_RS00925	34733..35287	-	555	WP_000790084.1	hypothetical protein	-
AM435_RS00930	35307..35525	-	219	WP_001043201.1	hypothetical protein	-
AM435_RS00935	35565..36194	-	630	WP_000701004.1	hypothetical protein	-
AM435_RS00940	36211..36390	-	180	WP_000387630.1	hypothetical protein	-
AM435_RS00945	36366..36938	-	573	WP_000443897.1	hypothetical protein	-
AM435_RS00950	36943..37200	-	258	WP_000834290.1	hypothetical protein	-
AM435_RS00955	37305..37757	-	453	Protein_50	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	blaOXA-23	-	1..72105	72105

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-like (14-109)

Antitoxin

• HigA2-like, helix-turn-helix domain (12-88)

Sequences

Toxin

Protein

• Length: 120 a.a.
• Molecular weight: 13751.62 Da
• Isoelectric Point: 4.8212

>T95493 WP_000312250.1 NZ_CP026706:32951-33310 [Acinetobacter baumannii]
MAWDVETTELFDSWLAEQDENAQDKILASLLVLSELGPNLGRPHVDTIKESKYPNMKEIRVQVKGHPIRGFFAFDPERKA
IVLCAGDKKGLNEKAFYKEMIKIADEQYEQYLRDNYGDK

Nucleotide

• Length: 360 bp

>T95493 NZ_CP026706:32951-33310 [Acinetobacter baumannii]
ATGGCTTGGGATGTAGAAACAACAGAACTTTTTGATTCTTGGTTGGCAGAACAAGATGAAAATGCTCAAGATAAAATCTT
AGCGTCTTTGCTTGTTTTGTCAGAACTGGGGCCAAATCTAGGCCGGCCTCATGTTGATACTATTAAAGAATCAAAATATC
CGAACATGAAAGAGATACGTGTGCAAGTTAAAGGTCATCCGATCCGTGGTTTCTTTGCATTTGATCCAGAACGTAAAGCC
ATTGTTTTGTGTGCTGGAGATAAGAAAGGGCTAAATGAAAAAGCCTTTTATAAAGAAATGATCAAGATTGCAGATGAACA
ATATGAGCAATATTTACGTGATAATTACGGAGATAAATAA

Antitoxin

Protein

• Length: 100 a.a.
• Molecular weight: 11012.93 Da
• Isoelectric Point: 10.4856

>AT95493 WP_001096429.1 NZ_CP026706:33310-33609 [Acinetobacter baumannii]
MAKLNDIISKRSPESQQRIKKMANQMLLDINLSNLREELKISQAEIAKNLGVSQAAISKREKLGKDLKISSLKEYVEAMG
GKVRLDVELPNGKHVAISI

Nucleotide

• Length: 300 bp

>AT95493 NZ_CP026706:33310-33609 [Acinetobacter baumannii]
ATGGCTAAATTAAACGATATAATTTCAAAACGCTCACCTGAAAGCCAACAACGCATCAAGAAAATGGCAAATCAAATGCT
ATTGGATATTAACCTATCGAACCTACGGGAAGAGTTAAAAATATCTCAAGCTGAAATTGCAAAAAATCTAGGTGTAAGCC
AAGCTGCTATTTCAAAACGTGAAAAATTAGGTAAAGATCTTAAGATTTCATCATTAAAAGAATATGTTGAAGCTATGGGT
GGCAAAGTAAGGTTAGATGTTGAGTTACCTAACGGAAAGCATGTTGCTATATCTATTTAA