Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 5030100..5030760 Replicon chromosome
Accession NZ_CP026702
Organism Serratia marcescens strain AR_0027

Toxin (Protein)


Gene name higB Uniprot ID A0A7D6BYZ0
Locus tag AM354_RS23955 Protein ID WP_041035904.1
Coordinates 5030100..5030453 (+) Length 118 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A2V4GQ69
Locus tag AM354_RS23960 Protein ID WP_033635213.1
Coordinates 5030458..5030760 (+) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AM354_RS23935 5026199..5026564 + 366 WP_033635218.1 diacylglycerol kinase -
AM354_RS23940 5026657..5027556 + 900 WP_039565149.1 LysR family transcriptional regulator -
AM354_RS23945 5027531..5028337 - 807 WP_049235462.1 substrate-binding domain-containing protein -
AM354_RS23950 5028365..5029660 - 1296 WP_049235463.1 MFS transporter -
AM354_RS23955 5030100..5030453 + 354 WP_041035904.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
AM354_RS23960 5030458..5030760 + 303 WP_033635213.1 XRE family transcriptional regulator Antitoxin
AM354_RS23965 5031168..5032376 + 1209 WP_049235464.1 aldose 1-epimerase family protein -
AM354_RS23975 5032980..5034098 + 1119 WP_033647954.1 branched-chain amino acid ABC transporter substrate-binding protein -
AM354_RS23980 5034224..5035138 + 915 WP_004928592.1 branched-chain amino acid ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(13-106)

Antitoxin

HigA2-like, helix-turn-helix domain

(12-89)


Sequences

Toxin        


Download         Length: 118 a.a.        Molecular weight: 13446.27 Da        Isoelectric Point: 8.9000

>T95490 WP_041035904.1 NZ_CP026702:5030100-5030453 [Serratia marcescens]
VWEIKTTDAFDNWFSSLHDADRAGVLAALMVLREKGPGLPRPYADTVKGSRYSNMKELRIQSRGEPLRAFFAFDPYRIGI
VLCAGNKAGNEKRFYDRMIQAADREFTNWLNTLNEKE

Download         Length: 354 bp

>T95490 NZ_CP026702:5030100-5030453 [Serratia marcescens]
GTGTGGGAAATTAAAACAACGGATGCGTTTGATAACTGGTTTAGCTCACTCCACGATGCCGATCGGGCTGGCGTGCTTGC
CGCATTGATGGTCCTGCGGGAAAAGGGGCCGGGGCTGCCCAGACCCTATGCCGATACGGTTAAAGGTTCGCGTTACAGCA
ATATGAAAGAGCTGCGCATTCAGAGCCGTGGCGAACCGTTGCGGGCATTCTTCGCCTTCGATCCGTACCGTATCGGCATT
GTGCTTTGCGCGGGCAATAAAGCCGGTAATGAAAAACGTTTTTACGATCGGATGATTCAGGCTGCCGATCGGGAATTCAC
GAACTGGCTGAACACATTAAACGAGAAGGAGTGA

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11079.94 Da        Isoelectric Point: 6.4738

>AT95490 WP_033635213.1 NZ_CP026702:5030458-5030760 [Serratia marcescens]
MGRTLEQLIADEKPEVVAKAQALAADIMLNIHLAELREKVQKTQVEMAQALGIRQPTVAVMEKPGRDLKLSSLKRYVEAA
GGKLRLDVELPDGSHYEFVL

Download         Length: 303 bp

>AT95490 NZ_CP026702:5030458-5030760 [Serratia marcescens]
ATGGGCAGAACGCTGGAACAGCTTATTGCGGATGAAAAGCCCGAGGTCGTGGCCAAAGCGCAAGCGCTGGCGGCTGACAT
CATGCTGAACATCCACCTTGCCGAGCTGCGCGAGAAGGTGCAGAAAACGCAGGTTGAAATGGCGCAGGCGCTGGGTATCC
GGCAACCGACCGTTGCCGTGATGGAAAAACCGGGCCGCGATCTGAAACTGTCTTCGCTCAAACGCTATGTTGAGGCGGCC
GGCGGCAAGCTGCGCCTGGATGTTGAACTGCCAGACGGCTCTCACTACGAATTTGTGCTGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7D6BYZ0

Antitoxin

Source ID Structure
AlphaFold DB A0A2V4GQ69

References