Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 3570231..3570961 Replicon chromosome
Accession NZ_CP026702
Organism Serratia marcescens strain AR_0027

Toxin (Protein)


Gene name higB Uniprot ID A0A2S4X738
Locus tag AM354_RS16885 Protein ID WP_033636137.1
Coordinates 3570650..3570961 (-) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A2V4GBG9
Locus tag AM354_RS16880 Protein ID WP_033636138.1
Coordinates 3570231..3570653 (-) Length 141 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AM354_RS16865 3566209..3566949 + 741 WP_004937022.1 KDGP aldolase family protein -
AM354_RS16870 3567044..3568258 + 1215 WP_049234181.1 lactonase family protein -
AM354_RS16875 3568310..3570226 + 1917 WP_033648995.1 BglG family transcription antiterminator -
AM354_RS16880 3570231..3570653 - 423 WP_033636138.1 helix-turn-helix domain-containing protein Antitoxin
AM354_RS16885 3570650..3570961 - 312 WP_033636137.1 type II toxin-antitoxin system HigB family toxin Toxin
AM354_RS16890 3571258..3571530 - 273 WP_033648996.1 PTS phosphocarrier protein NPr -
AM354_RS16895 3571527..3572381 - 855 WP_015379177.1 RNase adapter RapZ -
AM354_RS16900 3572511..3572972 - 462 WP_016930212.1 PTS IIA-like nitrogen regulatory protein PtsN -
AM354_RS16905 3573128..3573415 - 288 WP_004937038.1 ribosome hibernation promoting factor -
AM354_RS16910 3573439..3574872 - 1434 WP_033648997.1 RNA polymerase factor sigma-54 -
AM354_RS16915 3574925..3575650 - 726 WP_004937040.1 LPS export ABC transporter ATP-binding protein -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.



Sequences


Toxin        


Download         Length: 104 a.a.        Molecular weight: 12259.11 Da        Isoelectric Point: 10.0957

>T95485 WP_033636137.1 NZ_CP026702:c3570961-3570650 [Serratia marcescens]
MHIISREPFNNATKQYPNEAAALEAIYKALRRGEFRTPDELKALFPSLDRMKYKEKWWVIDVGGNHLRILFFASFETQKV
FIKHIVSHAEYDKLMQHYRRSSS

Download         Length: 312 bp

>T95485 NZ_CP026702:c3570961-3570650 [Serratia marcescens]
ATGCATATCATTTCCAGGGAGCCGTTCAATAACGCAACCAAGCAATACCCTAATGAAGCCGCTGCTCTCGAGGCCATTTA
TAAAGCGTTGCGACGCGGCGAGTTCCGCACGCCGGACGAGTTAAAAGCGCTTTTTCCTTCGCTCGATCGTATGAAATACA
AAGAGAAATGGTGGGTCATTGACGTCGGCGGCAACCACCTGCGGATTTTGTTCTTCGCCAGCTTCGAGACACAGAAAGTC
TTCATAAAGCATATCGTTAGCCACGCTGAGTACGACAAGCTGATGCAGCACTATCGAAGGAGTTCATCATGA

Antitoxin


Download         Length: 141 a.a.        Molecular weight: 15676.97 Da        Isoelectric Point: 4.9590

>AT95485 WP_033636138.1 NZ_CP026702:c3570653-3570231 [Serratia marcescens]
MITDAIKAADALLRAVPLLQGSSSQQDYREALELVEYLLENDEHHPLIDMLAKKIAEYEDNSAEFTAFNQRIAQLPQGVA
ALRVLMEQHQLSQSDFEHEIGKKSLVSQILSGKRSLTIPHIMALAKRFNLPPALFLPEAD

Download         Length: 423 bp

>AT95485 NZ_CP026702:c3570653-3570231 [Serratia marcescens]
ATGATTACAGATGCCATTAAGGCCGCCGATGCGCTGCTGCGCGCCGTGCCCTTATTGCAGGGCAGCAGCTCTCAGCAAGA
CTACCGGGAAGCGCTCGAATTGGTGGAATATCTGCTGGAAAACGATGAACACCATCCGCTGATTGACATGCTGGCAAAAA
AAATCGCCGAATATGAAGATAACAGCGCCGAATTTACCGCATTCAACCAGCGTATCGCCCAACTCCCGCAAGGAGTGGCC
GCGCTTCGCGTATTGATGGAACAACACCAACTTAGCCAAAGTGATTTTGAACATGAGATCGGTAAAAAGTCGTTGGTCAG
CCAAATCCTGAGTGGCAAAAGATCGCTGACCATTCCGCACATTATGGCGCTGGCCAAACGCTTCAATCTGCCCCCGGCCC
TCTTCCTGCCGGAAGCGGATTAG

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB A0A2S4X738


Antitoxin

Source ID Structure
AlphaFold DB A0A2V4GBG9

References