Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | higBA (relBE)/HigB-HigA |
Location | 3570231..3570961 | Replicon | chromosome |
Accession | NZ_CP026702 | ||
Organism | Serratia marcescens strain AR_0027 |
Toxin (Protein)
Gene name | higB | Uniprot ID | A0A2S4X738 |
Locus tag | AM354_RS16885 | Protein ID | WP_033636137.1 |
Coordinates | 3570650..3570961 (-) | Length | 104 a.a. |
Antitoxin (Protein)
Gene name | higA | Uniprot ID | A0A2V4GBG9 |
Locus tag | AM354_RS16880 | Protein ID | WP_033636138.1 |
Coordinates | 3570231..3570653 (-) | Length | 141 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
AM354_RS16865 | 3566209..3566949 | + | 741 | WP_004937022.1 | KDGP aldolase family protein | - |
AM354_RS16870 | 3567044..3568258 | + | 1215 | WP_049234181.1 | lactonase family protein | - |
AM354_RS16875 | 3568310..3570226 | + | 1917 | WP_033648995.1 | BglG family transcription antiterminator | - |
AM354_RS16880 | 3570231..3570653 | - | 423 | WP_033636138.1 | helix-turn-helix domain-containing protein | Antitoxin |
AM354_RS16885 | 3570650..3570961 | - | 312 | WP_033636137.1 | type II toxin-antitoxin system HigB family toxin | Toxin |
AM354_RS16890 | 3571258..3571530 | - | 273 | WP_033648996.1 | PTS phosphocarrier protein NPr | - |
AM354_RS16895 | 3571527..3572381 | - | 855 | WP_015379177.1 | RNase adapter RapZ | - |
AM354_RS16900 | 3572511..3572972 | - | 462 | WP_016930212.1 | PTS IIA-like nitrogen regulatory protein PtsN | - |
AM354_RS16905 | 3573128..3573415 | - | 288 | WP_004937038.1 | ribosome hibernation promoting factor | - |
AM354_RS16910 | 3573439..3574872 | - | 1434 | WP_033648997.1 | RNA polymerase factor sigma-54 | - |
AM354_RS16915 | 3574925..3575650 | - | 726 | WP_004937040.1 | LPS export ABC transporter ATP-binding protein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 104 a.a. Molecular weight: 12259.11 Da Isoelectric Point: 10.0957
>T95485 WP_033636137.1 NZ_CP026702:c3570961-3570650 [Serratia marcescens]
MHIISREPFNNATKQYPNEAAALEAIYKALRRGEFRTPDELKALFPSLDRMKYKEKWWVIDVGGNHLRILFFASFETQKV
FIKHIVSHAEYDKLMQHYRRSSS
MHIISREPFNNATKQYPNEAAALEAIYKALRRGEFRTPDELKALFPSLDRMKYKEKWWVIDVGGNHLRILFFASFETQKV
FIKHIVSHAEYDKLMQHYRRSSS
Download Length: 312 bp
>T95485 NZ_CP026702:c3570961-3570650 [Serratia marcescens]
ATGCATATCATTTCCAGGGAGCCGTTCAATAACGCAACCAAGCAATACCCTAATGAAGCCGCTGCTCTCGAGGCCATTTA
TAAAGCGTTGCGACGCGGCGAGTTCCGCACGCCGGACGAGTTAAAAGCGCTTTTTCCTTCGCTCGATCGTATGAAATACA
AAGAGAAATGGTGGGTCATTGACGTCGGCGGCAACCACCTGCGGATTTTGTTCTTCGCCAGCTTCGAGACACAGAAAGTC
TTCATAAAGCATATCGTTAGCCACGCTGAGTACGACAAGCTGATGCAGCACTATCGAAGGAGTTCATCATGA
ATGCATATCATTTCCAGGGAGCCGTTCAATAACGCAACCAAGCAATACCCTAATGAAGCCGCTGCTCTCGAGGCCATTTA
TAAAGCGTTGCGACGCGGCGAGTTCCGCACGCCGGACGAGTTAAAAGCGCTTTTTCCTTCGCTCGATCGTATGAAATACA
AAGAGAAATGGTGGGTCATTGACGTCGGCGGCAACCACCTGCGGATTTTGTTCTTCGCCAGCTTCGAGACACAGAAAGTC
TTCATAAAGCATATCGTTAGCCACGCTGAGTACGACAAGCTGATGCAGCACTATCGAAGGAGTTCATCATGA
Antitoxin
Download Length: 141 a.a. Molecular weight: 15676.97 Da Isoelectric Point: 4.9590
>AT95485 WP_033636138.1 NZ_CP026702:c3570653-3570231 [Serratia marcescens]
MITDAIKAADALLRAVPLLQGSSSQQDYREALELVEYLLENDEHHPLIDMLAKKIAEYEDNSAEFTAFNQRIAQLPQGVA
ALRVLMEQHQLSQSDFEHEIGKKSLVSQILSGKRSLTIPHIMALAKRFNLPPALFLPEAD
MITDAIKAADALLRAVPLLQGSSSQQDYREALELVEYLLENDEHHPLIDMLAKKIAEYEDNSAEFTAFNQRIAQLPQGVA
ALRVLMEQHQLSQSDFEHEIGKKSLVSQILSGKRSLTIPHIMALAKRFNLPPALFLPEAD
Download Length: 423 bp
>AT95485 NZ_CP026702:c3570653-3570231 [Serratia marcescens]
ATGATTACAGATGCCATTAAGGCCGCCGATGCGCTGCTGCGCGCCGTGCCCTTATTGCAGGGCAGCAGCTCTCAGCAAGA
CTACCGGGAAGCGCTCGAATTGGTGGAATATCTGCTGGAAAACGATGAACACCATCCGCTGATTGACATGCTGGCAAAAA
AAATCGCCGAATATGAAGATAACAGCGCCGAATTTACCGCATTCAACCAGCGTATCGCCCAACTCCCGCAAGGAGTGGCC
GCGCTTCGCGTATTGATGGAACAACACCAACTTAGCCAAAGTGATTTTGAACATGAGATCGGTAAAAAGTCGTTGGTCAG
CCAAATCCTGAGTGGCAAAAGATCGCTGACCATTCCGCACATTATGGCGCTGGCCAAACGCTTCAATCTGCCCCCGGCCC
TCTTCCTGCCGGAAGCGGATTAG
ATGATTACAGATGCCATTAAGGCCGCCGATGCGCTGCTGCGCGCCGTGCCCTTATTGCAGGGCAGCAGCTCTCAGCAAGA
CTACCGGGAAGCGCTCGAATTGGTGGAATATCTGCTGGAAAACGATGAACACCATCCGCTGATTGACATGCTGGCAAAAA
AAATCGCCGAATATGAAGATAACAGCGCCGAATTTACCGCATTCAACCAGCGTATCGCCCAACTCCCGCAAGGAGTGGCC
GCGCTTCGCGTATTGATGGAACAACACCAACTTAGCCAAAGTGATTTTGAACATGAGATCGGTAAAAAGTCGTTGGTCAG
CCAAATCCTGAGTGGCAAAAGATCGCTGACCATTCCGCACATTATGGCGCTGGCCAAACGCTTCAATCTGCCCCCGGCCC
TCTTCCTGCCGGAAGCGGATTAG
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A2S4X738 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A2V4GBG9 |