Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HTH(antitoxin)
Location 1020217..1020818 Replicon chromosome
Accession NZ_CP026675
Organism Pseudomonas sp. SWI36

Toxin (Protein)


Gene name higB Uniprot ID A0A2L1IAQ2
Locus tag C4Q27_RS05090 Protein ID WP_049587984.1
Coordinates 1020217..1020531 (+) Length 105 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A2L1IAR7
Locus tag C4Q27_RS05095 Protein ID WP_049587986.1
Coordinates 1020531..1020818 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C4Q27_RS05080 1016517..1017809 + 1293 WP_064492882.1 virulence factor family protein -
C4Q27_RS05085 1017858..1019768 - 1911 WP_104886573.1 potassium transporter Kup -
C4Q27_RS05090 1020217..1020531 + 315 WP_049587984.1 hypothetical protein Toxin
C4Q27_RS05095 1020531..1020818 + 288 WP_049587986.1 helix-turn-helix domain-containing protein Antitoxin
C4Q27_RS05100 1021019..1022350 + 1332 WP_064492880.1 30S ribosomal protein S12 methylthiotransferase RimO -
C4Q27_RS05105 1022422..1023171 - 750 WP_104886574.1 hypothetical protein -
C4Q27_RS05110 1023226..1024916 - 1691 Protein_956 hypothetical protein -
C4Q27_RS05115 1024913..1025758 - 846 WP_104886575.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(36-88)


Sequences

Toxin        


Download         Length: 105 a.a.        Molecular weight: 11784.61 Da        Isoelectric Point: 9.9097

>T95428 WP_049587984.1 NZ_CP026675:1020217-1020531 [Pseudomonas sp. SWI36]
MIFIETPVFTSDLKEHLDDEEYRALQAYLAEHPEAGSLLEETGGLRKIRWAAKGKGKSGGVRVIYYHVTAAHQIRMILIY
RKGIVDTLTSSQKAQLRALNKGWK

Download         Length: 315 bp

>T95428 NZ_CP026675:1020217-1020531 [Pseudomonas sp. SWI36]
ATGATCTTCATCGAGACCCCAGTATTCACCTCCGATCTCAAGGAGCACTTGGATGATGAAGAATACCGGGCTTTGCAGGC
CTATCTGGCCGAGCATCCCGAAGCCGGTTCTCTCCTGGAGGAAACCGGCGGCCTCAGAAAGATCCGCTGGGCAGCCAAGG
GCAAGGGCAAGAGTGGGGGTGTACGAGTGATCTACTACCACGTCACTGCAGCCCACCAGATCCGTATGATTCTGATCTAT
CGCAAGGGCATCGTGGATACCTTGACAAGCAGTCAGAAAGCGCAGCTTCGCGCACTAAACAAAGGGTGGAAATAA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10841.31 Da        Isoelectric Point: 7.4063

>AT95428 WP_049587986.1 NZ_CP026675:1020531-1020818 [Pseudomonas sp. SWI36]
MEKHLFDRLVESMTQMDEIDRGERQPSREFHVDALQVKKIRQATGLSQAAFAKRIDVAVGTLRNWEQGRREPEGPARALL
RAIHNDPEHVLAALS

Download         Length: 288 bp

>AT95428 NZ_CP026675:1020531-1020818 [Pseudomonas sp. SWI36]
ATGGAAAAGCATCTCTTCGATCGTCTTGTGGAAAGCATGACTCAGATGGATGAGATCGATCGCGGTGAGCGTCAGCCCTC
GCGTGAGTTCCACGTAGACGCACTTCAAGTCAAAAAGATTCGTCAAGCCACTGGCCTTTCCCAGGCTGCGTTTGCCAAAC
GTATCGATGTCGCAGTAGGAACTCTACGAAATTGGGAACAGGGCCGTCGCGAACCTGAAGGACCAGCTCGTGCCTTGCTT
CGAGCGATTCATAACGATCCCGAACATGTACTTGCGGCCTTGAGCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2L1IAQ2

Antitoxin

Source ID Structure
AlphaFold DB A0A2L1IAR7

References