Detailed information of TA system TA095398

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yefM-yoeB (relBE)/Txe-RelB
• Location: 991578..992083
• Replicon: chromosome
• Accession: NZ_CP026656
• Organism: Aliarcobacter cryaerophilus strain M830MA

Toxin (Protein)

• Gene name: yoeB
• Uniprot ID: -
• Locus tag: C2860_RS05125
• Protein ID: WP_148571227.1
• Coordinates: 991578..991844 (-)
• Length: 89 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: A0A1V9VC04
• Locus tag: C2860_RS05130
• Protein ID: WP_066157209.1
• Coordinates: 991838..992083 (-)
• Length: 82 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
C2860_RS05100	986675..987268	-	594	WP_066405017.1	FAD-dependent oxidoreductase	-
C2860_RS05105	987322..988026	-	705	WP_148571221.1	alpha/beta fold hydrolase	-
C2860_RS05110	988186..988380	+	195	WP_066348707.1	DUF2892 domain-containing protein	-
C2860_RS05115	988405..989703	-	1299	WP_148571223.1	M99 family carboxypeptidase catalytic domain-containing protein	-
C2860_RS05120	989937..991568	+	1632	WP_252971040.1	protein adenylyltransferase SelO family protein	-
C2860_RS05125	991578..991844	-	267	WP_148571227.1	Txe/YoeB family addiction module toxin	Toxin
C2860_RS05130	991838..992083	-	246	WP_066157209.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
C2860_RS05135	992284..992598	-	315	WP_148571229.1	HNH endonuclease	-
C2860_RS05140	992802..994337	-	1536	WP_148571231.1	glutamine-hydrolyzing GMP synthase	-
C2860_RS05145	994391..995842	-	1452	WP_148571233.1	FAD-binding protein	-
C2860_RS05150	995947..996387	+	441	WP_148571235.1	DUF721 domain-containing protein	-
C2860_RS05155	996389..996982	-	594	WP_148571237.1	DUF45 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (5-87)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (3-69)

Sequences

Toxin

Protein

• Length: 89 a.a.
• Molecular weight: 10230.95 Da
• Isoelectric Point: 10.0708

>T95398 WP_148571227.1 NZ_CP026656:c991844-991578 [Aliarcobacter cryaerophilus]
MVNYKLVYTKQAGKDAKKLSNSGLKSKALELLEIISLNPHQNPPPYEKLIGDLNNAISRRINIQHRLVYEVLEDIKTIKV
IRMWSHYE

Nucleotide

• Length: 267 bp

>T95398 NZ_CP026656:c991844-991578 [Aliarcobacter cryaerophilus]
ATGGTAAACTATAAACTTGTTTATACTAAACAAGCTGGAAAAGATGCCAAGAAATTATCTAATTCAGGCTTAAAATCAAA
GGCTTTGGAATTATTAGAGATAATTTCTTTAAATCCACATCAAAATCCCCCGCCTTATGAAAAACTAATTGGTGATTTAA
ATAATGCAATATCAAGAAGAATAAATATTCAACACAGATTAGTTTATGAAGTTTTAGAAGATATTAAAACTATAAAAGTG
ATACGAATGTGGTCACATTATGAGTAA

Antitoxin

Protein

• Length: 82 a.a.
• Molecular weight: 9284.61 Da
• Isoelectric Point: 4.2550

>AT95398 WP_066157209.1 NZ_CP026656:c992083-991838 [Aliarcobacter cryaerophilus]
MTKVMTVSQVRADIYNIIDETALTHEPILITGKRTNAVMLSQEDWNAIQETLYLTSIPNMRESIIKGLNTSIEDCDKELE
W

Nucleotide

• Length: 246 bp

>AT95398 NZ_CP026656:c992083-991838 [Aliarcobacter cryaerophilus]
ATGACGAAAGTTATGACAGTTAGTCAAGTTCGAGCAGATATTTATAATATTATTGATGAAACAGCATTAACACATGAACC
AATACTTATAACTGGTAAAAGAACAAATGCTGTTATGTTATCTCAAGAAGATTGGAATGCCATCCAAGAGACTTTATATC
TAACATCAATTCCAAATATGAGAGAGTCTATAATTAAAGGATTAAATACATCTATTGAAGATTGTGATAAAGAGTTAGAA
TGGTAA

Structures

Antitoxin

• AlphaFold DB: A0A1V9VC04