Detailed information of TA system TA095397

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yefM-yoeB (relBE)/Txe-RelB
• Location: 1157916..1158415
• Replicon: chromosome
• Accession: NZ_CP026655
• Organism: Aliarcobacter cryaerophilus strain G13RTA

Toxin (Protein)

• Gene name: yoeB
• Uniprot ID: -
• Locus tag: C3B42_RS05855
• Protein ID: WP_141052169.1
• Coordinates: 1158155..1158415 (+)
• Length: 87 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: A0A1V9VC04
• Locus tag: C3B42_RS05850
• Protein ID: WP_066157209.1
• Coordinates: 1157916..1158161 (+)
• Length: 82 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
C3B42_RS05825	1152993..1153586	+	594	WP_164469559.1	DUF45 domain-containing protein	-
C3B42_RS05830	1153588..1154028	-	441	WP_164469560.1	DUF721 domain-containing protein	-
C3B42_RS05835	1154133..1155584	+	1452	WP_164469561.1	FAD-binding protein	-
C3B42_RS05840	1155638..1157173	+	1536	WP_164469562.1	glutamine-hydrolyzing GMP synthase	-
C3B42_RS05845	1157400..1157714	+	315	WP_066168835.1	hypothetical protein	-
C3B42_RS05850	1157916..1158161	+	246	WP_066157209.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
C3B42_RS05855	1158155..1158415	+	261	WP_141052169.1	Txe/YoeB family addiction module toxin	Toxin
C3B42_RS10990	1158511..1158819	+	309	WP_206442784.1	transposase	-
C3B42_RS10995	1158806..1159528	+	723	WP_206442836.1	IS256 family transposase	-
C3B42_RS11000	1159462..1159749	+	288	WP_198306481.1	transposase	-
C3B42_RS05865	1159851..1161053	+	1203	WP_164469563.1	IS256 family transposase	-
C3B42_RS05870	1161136..1162838	-	1703	Protein_1152	YdiU family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	-	-	1014461..1159367	144906
	-	flank	IS/Tn	-	-	1159851..1161053	1202

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (24-82)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (3-69)

Sequences

Toxin

Protein

• Length: 87 a.a.
• Molecular weight: 9937.67 Da
• Isoelectric Point: 10.2283

>T95397 WP_141052169.1 NZ_CP026655:1158155-1158415 [Aliarcobacter cryaerophilus]
MVNYKLVYTKQAGKDAKKLSNSGLKSKALELLEIISLNPYQNPPPYEKLIGDLNSAISRRINIQHRLVYEVLEDIKTIKV
IRMWSH

Nucleotide

• Length: 261 bp

>T95397 NZ_CP026655:1158155-1158415 [Aliarcobacter cryaerophilus]
ATGGTAAACTATAAACTTGTTTATACTAAACAAGCTGGAAAAGATGCCAAGAAATTATCTAATTCAGGCTTAAAATCAAA
GGCTTTGGAATTATTAGAGATAATTTCTTTAAATCCATATCAAAATCCTCCGCCTTATGAAAAACTAATTGGTGATTTAA
ATAGTGCAATATCAAGAAGAATAAATATTCAACACAGATTAGTTTATGAAGTTTTAGAAGATATTAAAACTATAAAAGTG
ATACGAATGTGGTCACATTAG

Antitoxin

Protein

• Length: 82 a.a.
• Molecular weight: 9284.61 Da
• Isoelectric Point: 4.2550

>AT95397 WP_066157209.1 NZ_CP026655:1157916-1158161 [Aliarcobacter cryaerophilus]
MTKVMTVSQVRADIYNIIDETALTHEPILITGKRTNAVMLSQEDWNAIQETLYLTSIPNMRESIIKGLNTSIEDCDKELE
W

Nucleotide

• Length: 246 bp

>AT95397 NZ_CP026655:1157916-1158161 [Aliarcobacter cryaerophilus]
ATGACGAAAGTTATGACAGTTAGTCAAGTTCGAGCAGATATTTATAATATTATTGATGAAACAGCATTAACACATGAACC
AATACTTATAACTGGTAAAAGAACAAATGCTGTTATGTTATCTCAAGAAGATTGGAATGCCATCCAAGAGACTTTATATC
TAACATCAATTCCAAATATGAGAGAATCTATAATTAAAGGATTAAATACATCTATTGAAGATTGTGATAAAGAGTTAGAA
TGGTAA

Structures

Antitoxin

• AlphaFold DB: A0A1V9VC04