Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 2836678..2837264 Replicon chromosome
Accession NZ_CP026616
Organism Acinetobacter sp. SWBY1

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag C3Y93_RS13660 Protein ID WP_104853185.1
Coordinates 2836956..2837264 (-) Length 103 a.a.

Antitoxin (Protein)


Gene name graA Uniprot ID -
Locus tag C3Y93_RS13655 Protein ID WP_004971994.1
Coordinates 2836678..2836959 (-) Length 94 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C3Y93_RS13630 2831702..2832880 - 1179 WP_104853183.1 FAD-dependent oxidoreductase -
C3Y93_RS13635 2832953..2833117 - 165 WP_004972007.1 rubredoxin -
C3Y93_RS13640 2833613..2834155 + 543 WP_004972003.1 adenine phosphoribosyltransferase -
C3Y93_RS13645 2834266..2834772 - 507 WP_104853299.1 alpha/beta fold hydrolase -
C3Y93_RS13650 2835079..2836605 + 1527 WP_104853184.1 lysine--tRNA ligase -
C3Y93_RS13655 2836678..2836959 - 282 WP_004971994.1 HigA family addiction module antidote protein Antitoxin
C3Y93_RS13660 2836956..2837264 - 309 WP_104853185.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
C3Y93_RS13665 2837391..2837921 - 531 WP_096900966.1 hypothetical protein -
C3Y93_RS13670 2838276..2839184 + 909 WP_026438300.1 sulfate adenylyltransferase subunit CysD -
C3Y93_RS13675 2839329..2840945 + 1617 WP_104853186.1 sulfate adenylyltransferase subunit CysN -
C3Y93_RS13680 2841030..2841497 - 468 WP_104853187.1 GNAT family N-acetyltransferase -
C3Y93_RS13685 2841779..2842255 + 477 WP_104853188.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(1-93)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(4-80)


Sequences

Toxin        


Download         Length: 103 a.a.        Molecular weight: 11468.07 Da        Isoelectric Point: 10.2252

>T95303 WP_104853185.1 NZ_CP026616:c2837264-2836956 [Acinetobacter sp. SWBY1]
MIKSFKHKGLQAFFQTGSTAGIQAAHSTKLRLILAALHAASTVNDLRTPPNWRLHKLSANLQDQWSLTVNGNWRVIFKFE
DGDVYIVDYLDYHIASSAGVQR

Download         Length: 309 bp

>T95303 NZ_CP026616:c2837264-2836956 [Acinetobacter sp. SWBY1]
TTGATTAAGAGTTTTAAACATAAAGGTCTTCAGGCTTTTTTCCAAACTGGTTCAACAGCAGGTATTCAAGCAGCGCATTC
TACAAAATTACGTTTAATACTTGCAGCACTACATGCTGCATCTACGGTGAATGATTTGCGAACTCCACCCAATTGGCGTT
TACATAAATTGAGTGCAAATCTACAAGATCAATGGTCACTAACAGTAAATGGTAATTGGCGTGTAATTTTTAAATTTGAA
GATGGTGATGTCTACATTGTAGATTATTTGGATTATCACATAGCTTCTAGCGCAGGAGTACAAAGATGA

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10451.10 Da        Isoelectric Point: 6.7228

>AT95303 WP_004971994.1 NZ_CP026616:c2836959-2836678 [Acinetobacter sp. SWBY1]
MNMMFNAPHPGEMLREYIGETSVTEVAQALGVTRANLSRILNGHTGISADMAIRLSEALETSPEFWLNLQMQHDLWLASQ
RQRPMIKKLVASV

Download         Length: 282 bp

>AT95303 NZ_CP026616:c2836959-2836678 [Acinetobacter sp. SWBY1]
ATGAATATGATGTTTAATGCACCTCATCCGGGCGAAATGTTGCGCGAATATATTGGTGAAACTTCTGTGACTGAAGTGGC
TCAAGCACTTGGAGTGACACGTGCAAACCTATCTCGCATTTTGAATGGTCATACTGGAATTTCTGCAGATATGGCGATTC
GTTTGAGTGAAGCCTTAGAAACCTCACCAGAGTTTTGGTTGAATTTACAAATGCAGCATGATTTATGGCTTGCCAGTCAA
CGCCAGCGACCTATGATCAAAAAATTGGTGGCAAGTGTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References