95055

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RHH(antitoxin)
Location 1662322..1662856 Replicon plasmid pSymB
Accession NZ_CP026527
Organism Sinorhizobium meliloti strain AK21

Toxin (Protein)


Gene name parE Uniprot ID Q92X99
Locus tag C3L21_RS34185 Protein ID WP_010974986.1
Coordinates 1662322..1662618 (-) Length 99 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID H0FXK0
Locus tag C3L21_RS34190 Protein ID WP_003527850.1
Coordinates 1662608..1662856 (-) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C3L21_RS34155 1657766..1659169 - 1404 WP_010974991.1 sodium:alanine symporter family protein -
C3L21_RS34160 1659703..1659912 - 210 WP_003527838.1 dodecin family protein -
C3L21_RS34165 1660202..1660648 + 447 WP_164825335.1 DNA-binding protein -
C3L21_RS34170 1660652..1660837 - 186 WP_010974989.1 hypothetical protein -
C3L21_RS34175 1661004..1661402 - 399 WP_010974988.1 hypothetical protein -
C3L21_RS34180 1661981..1662241 + 261 Protein_1508 helix-turn-helix domain containing protein -
C3L21_RS34185 1662322..1662618 - 297 WP_010974986.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
C3L21_RS34190 1662608..1662856 - 249 WP_003527850.1 type II toxin-antitoxin system ParD family antitoxin Antitoxin
C3L21_RS34195 1662964..1663119 - 156 WP_010974985.1 hypothetical protein -
C3L21_RS34200 1663475..1663600 + 126 Protein_1512 IS481 family transposase -
C3L21_RS34205 1663759..1664955 - 1197 WP_158528774.1 IS256-like element ISRm5 family transposase -
C3L21_RS34210 1665047..1665826 - 780 WP_010974982.1 methyltransferase domain-containing protein -
C3L21_RS34215 1665830..1666630 - 801 WP_127545452.1 ABC transporter ATP-binding protein -
C3L21_RS34220 1666627..1667670 - 1044 WP_010974980.1 iron ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Mobilizable plasmid - htpB 1..1676618 1676618


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(8-91)

Antitoxin

Antitoxin ParD

(3-78)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11473.15 Da        Isoelectric Point: 10.6593

>T95055 WP_010974986.1 NZ_CP026527:c1662618-1662322 [Sinorhizobium meliloti]
MATERPFRLAPTAKADLRKIWRYTARRWSLEQAETYQDQLYTAFEGLAVGTKKGRNVDVRPGYLKYPAGAHIVYFRDRGD
RIDIIRILHGRVDAQRHL

Download         Length: 297 bp

>T95055 NZ_CP026527:c1662618-1662322 [Sinorhizobium meliloti]
ATGGCGACTGAACGGCCTTTCCGGCTCGCTCCTACCGCCAAGGCCGACCTTCGGAAGATATGGCGCTACACGGCTCGCCG
CTGGTCTCTGGAACAGGCGGAGACCTACCAAGACCAGCTTTATACTGCATTTGAGGGACTGGCCGTAGGGACGAAGAAAG
GCCGCAATGTCGATGTGCGGCCGGGTTATCTCAAATACCCGGCAGGAGCGCACATCGTCTATTTTCGGGATCGCGGCGAC
CGGATCGACATCATCCGCATCCTGCATGGCCGTGTGGACGCCCAACGGCATTTGTAG

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 8888.73 Da        Isoelectric Point: 4.2176

>AT95055 WP_003527850.1 NZ_CP026527:c1662856-1662608 [Sinorhizobium meliloti]
MAARSTSISLGDHFAGFIDSQVQTGRYGSASDVVRAGLRLLEEHEAKVRALEAALIEGEESGEPEPFDNEAFKAEMRAEY
GD

Download         Length: 249 bp

>AT95055 NZ_CP026527:c1662856-1662608 [Sinorhizobium meliloti]
ATGGCTGCTAGAAGCACATCTATTTCCCTTGGCGATCACTTCGCCGGTTTCATCGACAGCCAGGTGCAAACCGGCCGCTA
CGGCTCCGCCAGCGACGTTGTGCGGGCTGGACTTCGGCTTTTGGAAGAACACGAGGCGAAGGTAAGGGCGCTGGAAGCGG
CTTTGATCGAGGGCGAAGAATCCGGCGAGCCAGAGCCATTCGACAACGAAGCGTTCAAAGCCGAAATGCGCGCCGAATAT
GGCGACTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q92X99

Antitoxin

Source ID Structure
AlphaFold DB H0FXK0

References