950

Detailed information of TA system    

experimentalExperimentally validated    

Overview

TA module


Type II Classification (family/domain) vapBC/-
Location 1682955..1683934 Replicon chromosome
Accession NC_002754
Organism Sulfolobus solfataricus P2

Toxin (Protein)


Gene name vapC Uniprot ID Q97X87
Locus tag SSO_RS09000 Protein ID WP_009988462.1
Coordinates 1683320..1683934 (+) Length 205 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID Q97X88
Locus tag SSO_RS08995 Protein ID WP_009988464.1
Coordinates 1682955..1683302 (+) Length 116 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SSO_RS08965 (SSO1861) 1678371..1679213 + 843 WP_009988518.1 KaiC domain-containing protein -
SSO_RS08970 (SSO1863) 1679250..1680446 + 1197 WP_009988517.1 MFS transporter -
SSO_RS08975 (SSO1864) 1680391..1681323 + 933 WP_009988516.1 dipeptidase -
SSO_RS08980 (SSO1865) 1681749..1682180 + 432 WP_009988468.1 universal stress protein -
SSO_RS08985 (SSO1866) 1682173..1682562 - 390 WP_009988467.1 metal-sulfur cluster assembly factor -
SSO_RS08990 1682655..1682885 + 231 WP_009988466.1 C2H2-type zinc finger protein -
SSO_RS08995 (SSO1867) 1682955..1683302 + 348 WP_009988464.1 DUF488 domain-containing protein Antitoxin
SSO_RS09000 (SSO1868) 1683320..1683934 + 615 WP_009988462.1 helix-turn-helix domain-containing protein Toxin
SSO_RS09005 (SSO9092) 1684224..1684499 - 276 WP_009988461.1 hypothetical protein -
SSO_RS09010 (SSO1869) 1684621..1685151 + 531 WP_009988460.1 hemerythrin domain-containing protein -
SSO_RS09015 (SSO1870) 1685257..1685934 + 678 Protein_1795 hypothetical protein -
SSO_RS09020 (SSO1871) 1686031..1686990 + 960 WP_010923632.1 IS5-like element ISC1234 family transposase -
SSO_RS16440 (SSO1872) 1687137..1687502 - 366 WP_231918270.1 hypothetical protein -
SSO_RS09025 (SSO1873) 1687602..1688417 + 816 WP_010923634.1 DUF929 domain-containing protein -
SSO_RS09030 (SSO1874) 1688414..1688794 + 381 WP_009992687.1 vitamin K epoxide reductase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
flank IS/Tn - - 1686031..1686990 959


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Bacterioopsin activator-type, HTH domain

(145-197)

Antitoxin

Protein of unknown function DUF488

(3-108)


Sequences

Toxin        


Download         Length: 205 a.a.        Molecular weight: 23424.52 Da        Isoelectric Point: 8.6438

>T950 WP_009988462.1 NC_002754:1683320-1683934 [Saccharolobus solfataricus P2]
MLKSPFEATILIEEHPCEVMKIISSTGLKGVVDNVKLGDNTTDHIVLFEKEVQKDDLIKLKSHSTKVLRLNDNKIWVRTY
GCAVCKILYTSNVVVEKIKVVRERTLLYTLLIPNTMALKEFLASLISQDIEFTVLSTSEISSNELTDRQMEILKLAYKMG
YFDDDRRVTLTELAKQLGISTPTLEEILRRALRKVVKFYLDKVR

Download         Length: 615 bp

>T950 NC_002754:1683320-1683934 [Saccharolobus solfataricus P2]
ATGTTAAAATCACCATTTGAAGCAACAATCCTAATTGAGGAGCACCCTTGTGAAGTAATGAAGATAATATCTAGTACTGG
GCTTAAAGGTGTTGTTGATAACGTTAAACTTGGAGATAATACAACCGATCACATAGTACTTTTCGAAAAAGAGGTCCAAA
AAGATGATCTAATTAAGCTTAAATCGCATAGTACTAAGGTTTTAAGGCTTAACGATAACAAGATATGGGTTAGAACTTAC
GGATGTGCAGTATGTAAGATTCTATATACTTCAAACGTCGTTGTAGAGAAAATAAAGGTAGTAAGAGAGAGGACATTGCT
CTATACTCTCTTAATCCCTAATACGATGGCACTTAAGGAATTTCTGGCAAGCCTCATAAGTCAAGATATAGAGTTTACAG
TGCTAAGCACTTCTGAAATAAGTAGTAATGAGTTAACTGATAGACAAATGGAAATATTGAAGCTTGCGTATAAGATGGGT
TATTTCGATGACGATAGGAGGGTTACTTTAACTGAGCTAGCAAAACAATTGGGAATTTCTACACCAACTTTAGAGGAGAT
TTTGCGTAGGGCTTTAAGGAAAGTTGTCAAGTTTTACTTAGATAAGGTAAGATAG

Antitoxin


Download         Length: 116 a.a.        Molecular weight: 13662.96 Da        Isoelectric Point: 9.9061

>AT950 WP_009988464.1 NC_002754:1682955-1683302 [Saccharolobus solfataricus P2]
MIKLKRVYDPIERDDGIRILVDRLWPRGIGKDKVDLWLKDIAPSDELRKWFSHDTSKWDEFKKKYFEELDANPKISVLLQ
LIKKGENITLLYASKSPYNNAVALKEYLEKKILKQ

Download         Length: 348 bp

>AT950 NC_002754:1682955-1683302 [Saccharolobus solfataricus P2]
ATGATTAAATTAAAGAGAGTTTACGATCCAATAGAAAGGGATGATGGAATAAGGATCTTAGTGGATAGGTTATGGCCAAG
AGGTATTGGCAAGGATAAAGTCGATTTGTGGCTCAAAGACATAGCGCCTAGTGATGAATTACGAAAGTGGTTTAGTCACG
ATACTAGTAAATGGGACGAGTTCAAAAAGAAATATTTTGAAGAATTAGATGCTAATCCAAAGATAAGCGTACTATTACAA
TTAATTAAAAAAGGTGAAAATATTACTTTACTTTACGCTTCAAAGTCACCGTATAATAATGCAGTAGCGTTAAAGGAGTA
TCTAGAAAAAAAGATATTAAAACAATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E3MDP8

Antitoxin

Source ID Structure
AlphaFold DB A0A0E3GU05

References

(1) Charlotte R Cooper et al. (2009) Role of vapBC toxin-antitoxin loci in the thermal stress response of Sulfolobus solfataricus. Biochemical Society Transactions 37(Pt 1):123-6. [PubMed:19143615] experimental

(2) Sabrina Tachdjian et al. (2006) Dynamic metabolic adjustments and genome plasticity are implicated in the heat shock response of the extremely thermoacidophilic archaeon Sulfolobus solfataricus. Journal of Bacteriology 188(12):4553-9. [PubMed:16740961] experimental


experimental experimental literature