293129

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/HTH_10(toxin)
Location 1721039..1722018 Replicon chromosome
Accession NZ_LT549890
Organism Saccharolobus solfataricus strain P1

Toxin (Protein)


Gene name vapC Uniprot ID Q97X87
Locus tag SSOP1_RS09200 Protein ID WP_009988462.1
Coordinates 1721039..1721653 (-) Length 205 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID Q97X88
Locus tag SSOP1_RS09205 Protein ID WP_009988464.1
Coordinates 1721671..1722018 (-) Length 116 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SSOP1_RS09170 (SSOP1_1929) 1717149..1717391 + 243 WP_009988456.1 hypothetical protein -
SSOP1_RS09175 (SSOP1_1930) 1717372..1717716 - 345 WP_009988458.1 hypothetical protein -
SSOP1_RS16505 1717720..1717815 - 96 Protein_1841 plastocyanin/azurin family copper-binding protein -
SSOP1_RS09180 (SSOP1_1931) 1717983..1718942 - 960 WP_010924011.1 IS5-like element ISC1234 family transposase -
SSOP1_RS09185 (SSOP1_1932) 1719039..1719716 - 678 Protein_1843 hypothetical protein -
SSOP1_RS09190 (SSOP1_1933) 1719822..1720352 - 531 WP_009988460.1 hemerythrin domain-containing protein -
SSOP1_RS09195 (SSOP1_1934) 1720474..1720749 + 276 WP_009988461.1 hypothetical protein -
SSOP1_RS09200 (SSOP1_1935) 1721039..1721653 - 615 WP_009988462.1 helix-turn-helix domain-containing protein Toxin
SSOP1_RS09205 (SSOP1_1936) 1721671..1722018 - 348 WP_009988464.1 DUF488 domain-containing protein Antitoxin
SSOP1_RS09210 (SSOP1_1937) 1722088..1722318 - 231 WP_009988466.1 C2H2-type zinc finger protein -
SSOP1_RS09215 (SSOP1_1938) 1722411..1722800 + 390 WP_009988467.1 metal-sulfur cluster assembly factor -
SSOP1_RS09220 (SSOP1_1939) 1722793..1723224 - 432 WP_009988468.1 universal stress protein -
SSOP1_RS09225 (SSOP1_1940) 1723650..1724582 - 933 WP_009988516.1 dipeptidase -
SSOP1_RS09230 (SSOP1_1941) 1724527..1725723 - 1197 WP_009988517.1 MFS transporter -
SSOP1_RS09235 (SSOP1_1942) 1725760..1726602 - 843 WP_009988518.1 KaiC domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
flank IS/Tn - - 1717983..1718942 959


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Bacterioopsin activator-type, HTH domain

(145-197)

Antitoxin

Protein of unknown function DUF488

(3-108)


Sequences

Toxin        


Download         Length: 205 a.a.        Molecular weight: 23424.52 Da        Isoelectric Point: 8.6438

>T293129 WP_009988462.1 NZ_LT549890:c1721653-1721039 [Saccharolobus solfataricus]
MLKSPFEATILIEEHPCEVMKIISSTGLKGVVDNVKLGDNTTDHIVLFEKEVQKDDLIKLKSHSTKVLRLNDNKIWVRTY
GCAVCKILYTSNVVVEKIKVVRERTLLYTLLIPNTMALKEFLASLISQDIEFTVLSTSEISSNELTDRQMEILKLAYKMG
YFDDDRRVTLTELAKQLGISTPTLEEILRRALRKVVKFYLDKVR

Download         Length: 615 bp

Antitoxin


Download         Length: 116 a.a.        Molecular weight: 13662.96 Da        Isoelectric Point: 9.9061

>AT293129 WP_009988464.1 NZ_LT549890:c1722018-1721671 [Saccharolobus solfataricus]
MIKLKRVYDPIERDDGIRILVDRLWPRGIGKDKVDLWLKDIAPSDELRKWFSHDTSKWDEFKKKYFEELDANPKISVLLQ
LIKKGENITLLYASKSPYNNAVALKEYLEKKILKQ

Download         Length: 348 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E3MDP8

Antitoxin

Source ID Structure
AlphaFold DB A0A0E3GU05

References