Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) hok-sok/-
Location 3709626..3709884 Replicon chromosome
Accession NZ_CP026491
Organism Escherichia coli strain HS13-1

Toxin (Protein)


Gene name hokC Uniprot ID S1NX00
Locus tag C3K24_RS19190 Protein ID WP_000809168.1
Coordinates 3709626..3709778 (-) Length 51 a.a.

Antitoxin (RNA)


Gene name sokC
Locus tag -
Coordinates 3709827..3709884 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C3K24_RS19170 3704871..3705584 - 714 WP_001102393.1 acidic protein MsyB -
C3K24_RS19175 3705610..3706014 - 405 WP_000843687.1 DUF2541 family protein -
C3K24_RS19180 3706386..3708302 + 1917 WP_000516135.1 molecular chaperone DnaK -
C3K24_RS19185 3708391..3709521 + 1131 WP_001118464.1 molecular chaperone DnaJ -
C3K24_RS19190 3709626..3709778 - 153 WP_000809168.1 type I toxin-antitoxin system toxin MokC Toxin
- 3709827..3709884 + 58 - - Antitoxin
C3K24_RS19195 3710390..3711151 + 762 WP_001274823.1 hypothetical protein -
C3K24_RS19200 3711171..3712664 + 1494 WP_104976683.1 sulfatase-like hydrolase/transferase -
C3K24_RS19205 3712793..3714052 + 1260 WP_000494924.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Hok/gef cell toxic protein

(6-47)


Sequences

Toxin        


Download         Length: 51 a.a.        Molecular weight: 5501.57 Da        Isoelectric Point: 7.1312

>T94989 WP_000809168.1 NZ_CP026491:c3709778-3709626 [Escherichia coli]
MKQHKAMIVALIVICITAVVAALVTRKDLCEVHIRTGQTEVAVFTAYESE

Download         Length: 153 bp

>T94989 NZ_CP026491:c3709778-3709626 [Escherichia coli]
ATGAAGCAGCATAAGGCGATGATTGTCGCCCTGATCGTCATCTGTATCACCGCCGTAGTGGCGGCGCTGGTAACGAGAAA
AGACCTCTGTGAGGTTCACATCCGAACTGGCCAGACGGAGGTTGCTGTTTTCACGGCTTACGAATCCGAGTAA

Antitoxin


Download         Length: 58 bp

>AT94989 NZ_CP026491:3709827-3709884 [Escherichia coli]
GTTCTGCATATAGGGGGCCTCGGGTTGATGGTAAAATATCACTCGGGGCTTTTCTCTA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1NX00

Antitoxin

Download structure file

References