Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 2528852..2529507 Replicon chromosome
Accession NZ_CP026436
Organism Bordetella pertussis strain J336

Toxin (Protein)


Gene name mqsR Uniprot ID -
Locus tag C3E13_RS12300 Protein ID WP_047122780.1
Coordinates 2529256..2529507 (-) Length 84 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID Q7VY40
Locus tag C3E13_RS12295 Protein ID WP_003809516.1
Coordinates 2528852..2529253 (-) Length 134 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C3E13_RS12265 2524035..2525057 - 1023 WP_003809532.1 amino acid ABC transporter substrate-binding protein -
C3E13_RS12270 2525194..2526231 - 1038 WP_023853543.1 threonylcarbamoyl-AMP synthase -
C3E13_RS12275 2526251..2527441 - 1191 WP_010930406.1 5-(carboxyamino)imidazole ribonucleotide synthase -
C3E13_RS12280 2527444..2527959 - 516 WP_019247930.1 5-(carboxyamino)imidazole ribonucleotide mutase -
C3E13_RS12285 2528109..2528588 - 480 WP_010930405.1 disulfide bond formation protein B -
C3E13_RS12290 2528596..2528832 - 237 WP_010930404.1 membrane protein -
C3E13_RS12295 2528852..2529253 - 402 WP_003809516.1 type II toxin-antitoxin system MqsA family antitoxin Antitoxin
C3E13_RS12300 2529256..2529507 - 252 WP_047122780.1 type II toxin-antitoxin system MqsR family toxin Toxin
C3E13_RS12305 2529562..2530443 - 882 WP_003809513.1 phosphoribosylaminoimidazolesuccinocarboxamide synthase -
C3E13_RS12310 2530668..2531114 + 447 WP_003819827.1 GFA family protein -
C3E13_RS12315 2531199..2532263 - 1065 WP_003809510.1 fructose-bisphosphate aldolase class II -
C3E13_RS12320 2532400..2532981 - 582 WP_019247931.1 molybdenum cofactor biosysynthesis protein -
C3E13_RS12325 2533216..2534346 + 1131 WP_010930401.1 helix-turn-helix transcriptional regulator -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(10-82)

Antitoxin

(1-131)


Sequences


Toxin        


Download         Length: 84 a.a.        Molecular weight: 8952.52 Da        Isoelectric Point: 9.7242

>T94868 WP_047122780.1 NZ_CP026436:c2529507-2529256 [Bordetella pertussis]
IGGAATKKPGQKRRAGAAALGLDFSAMVEIVLALTPRDFHKSMTTHADHRIWQDVYCPVTAMGAVYLKLTVLDGVPIVSF
KEL

Download         Length: 252 bp

>T94868 NZ_CP026436:c2529507-2529256 [Bordetella pertussis]
ATTGGAGGCGCGGCGACAAAAAAGCCGGGACAAAAGCGTCGCGCCGGGGCGGCGGCGCTGGGGCTGGATTTCAGCGCCAT
GGTCGAAATCGTGCTTGCATTGACACCGCGGGATTTCCACAAAAGCATGACTACCCATGCCGACCATCGCATTTGGCAGG
ACGTCTATTGCCCGGTGACAGCGATGGGCGCCGTCTACCTGAAGCTGACGGTCCTCGACGGCGTGCCGATCGTGTCGTTC
AAGGAGTTGTGA

Antitoxin


Download         Length: 134 a.a.        Molecular weight: 14528.70 Da        Isoelectric Point: 8.5005

>AT94868 WP_003809516.1 NZ_CP026436:c2529253-2528852 [Bordetella pertussis]
MKCPVCGAAALARDTRDVPYSYKGETITIAAVTGDWCPACGENVLDGAESARVSEAMLAFNRLVNARRVDPGFIVRVRRK
LGLDQREAAALFGGGTNAFSRYENGKTRPPLALVKLLRLLDRHPELLEEVRAD

Download         Length: 402 bp

>AT94868 NZ_CP026436:c2529253-2528852 [Bordetella pertussis]
ATGAAGTGTCCCGTATGCGGAGCGGCCGCGCTGGCGCGTGATACTCGCGATGTGCCCTATAGCTACAAGGGCGAGACCAT
CACGATTGCGGCGGTGACGGGCGACTGGTGTCCGGCATGCGGCGAGAACGTGCTCGATGGCGCTGAATCGGCGCGGGTGA
GCGAGGCCATGCTGGCTTTCAACCGCCTGGTCAACGCCCGCCGCGTCGACCCCGGGTTCATCGTGCGGGTGCGCAGGAAG
CTGGGGCTGGACCAGCGCGAAGCCGCGGCGCTGTTCGGCGGCGGCACCAATGCGTTCTCGCGTTACGAGAACGGCAAGAC
GCGCCCGCCGCTGGCGCTGGTGAAGCTGCTCAGGCTGCTGGATCGCCATCCGGAGCTGCTGGAGGAAGTCCGTGCGGATT
GA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure


Antitoxin

Source ID Structure
AlphaFold DB A0A0H3LKS6

References