94846

Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) higBA (relBE)/RelE-HTH
Location 5846..6431 Replicon plasmid pKPC-8dee
Accession NZ_CP026418
Organism Acinetobacter sp. ACNIH2

Toxin (Protein)


Gene name higB Uniprot ID N9CJF7
Locus tag C3F34_RS19760 Protein ID WP_000897307.1
Coordinates 5846..6166 (+) Length 107 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag C3F34_RS19765 Protein ID WP_000369781.1
Coordinates 6159..6431 (+) Length 91 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C3F34_RS19725 1268..2755 - 1488 WP_104442463.1 SulP family inorganic anion transporter -
C3F34_RS19730 3267..3554 + 288 WP_000438825.1 BrnT family toxin -
C3F34_RS19735 3541..3855 + 315 WP_004728120.1 BrnA antitoxin family protein -
C3F34_RS19740 3944..4474 - 531 WP_000172759.1 hypothetical protein -
C3F34_RS19745 4623..4925 + 303 WP_000286964.1 type II toxin-antitoxin system RelE/ParE family toxin -
C3F34_RS19750 4926..5207 + 282 WP_000985609.1 putative addiction module antidote protein -
C3F34_RS19755 5287..5706 - 420 WP_001180106.1 SMI1/KNR4 family protein -
C3F34_RS19760 5846..6166 + 321 WP_000897307.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
C3F34_RS19765 6159..6431 + 273 WP_000369781.1 helix-turn-helix domain-containing protein Antitoxin
C3F34_RS19770 6924..8399 + 1476 WP_000052512.1 ABC-F type ribosomal protection protein Msr(E) -
C3F34_RS19775 8551..9213 - 663 WP_104440784.1 IS1595 family transposase -
C3F34_RS19780 9254..10078 + 825 WP_104442464.1 Mph(E) family macrolide 2'-phosphotransferase -
C3F34_RS19785 10268..10879 - 612 WP_015060246.1 recombinase family protein -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid msr(E) / mph(E) / tet(39) / blaKPC-2 / blaGES-7 / qacE / sul1 - 1..43928 43928
- flank IS/Tn msr(E) / mph(E) / tet(39) - 6924..12292 5368


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(41-102)

Antitoxin

(37-85)


Sequences


Toxin        


Download         Length: 107 a.a.        Molecular weight: 12187.95 Da        Isoelectric Point: 7.1639

>T94846 WP_000897307.1 NZ_CP026418:5846-6166 [Acinetobacter sp. ACNIH2]
MLFIETSIFTKQIKDLVSDEEYRQLQQDLLVQPDRGDLIKNGGGIRKVRCAQGNKGKSGGIRVIYYWVTEDDQIFFLVAY
PKSVKDNLTDKETAILHQLVKEQFHG

Download         Length: 321 bp

>T94846 NZ_CP026418:5846-6166 [Acinetobacter sp. ACNIH2]
ATGTTATTTATTGAAACCAGCATCTTTACCAAGCAAATTAAAGACCTTGTATCTGATGAGGAATATCGTCAACTTCAGCA
AGATCTTTTGGTACAGCCTGATAGAGGTGACCTAATCAAGAATGGCGGTGGTATTCGCAAAGTACGTTGTGCTCAAGGTA
ACAAAGGGAAAAGTGGTGGGATACGGGTGATTTATTATTGGGTCACCGAGGATGATCAGATCTTTTTCTTAGTGGCTTAT
CCAAAATCAGTAAAAGATAATTTAACAGATAAGGAAACCGCCATTCTGCACCAACTCGTGAAGGAGCAATTTCATGGATA
A

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 10149.61 Da        Isoelectric Point: 8.6582

>AT94846 WP_000369781.1 NZ_CP026418:6159-6431 [Acinetobacter sp. ACNIH2]
MDNNLFDDLVASIKEAGAIKRKEVKASRVTELELPDIKEVREKTGLSQNEFAARLHISPRTLQNWEQGRRYPTGPAATLI
RILDAHPSLI

Download         Length: 273 bp

>AT94846 NZ_CP026418:6159-6431 [Acinetobacter sp. ACNIH2]
ATGGATAACAACTTATTTGATGACTTGGTTGCTTCAATCAAAGAAGCTGGAGCTATCAAACGTAAAGAAGTTAAAGCAAG
CCGAGTTACAGAACTCGAATTGCCTGATATTAAAGAAGTACGTGAAAAAACTGGCTTGAGCCAAAATGAATTTGCTGCAC
GTCTACATATTAGCCCCCGTACCCTGCAAAATTGGGAACAGGGACGACGCTATCCAACTGGACCAGCAGCTACATTGATT
CGAATTTTAGATGCTCACCCAAGCCTTATTTGA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB A0A0A8TMZ3


Antitoxin

Source ID Structure

References