Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | higBA (relBE)/COG4683-HTH_37 |
| Location | 6205..6862 | Replicon | plasmid pECO-c85f |
| Accession | NZ_CP026405 | ||
| Organism | Escherichia coli strain ECONIH4 | ||
Toxin (Protein)
| Gene name | higB | Uniprot ID | U3PDC3 |
| Locus tag | C3F40_RS29990 | Protein ID | WP_000270043.1 |
| Coordinates | 6205..6555 (+) | Length | 117 a.a. |
Antitoxin (Protein)
| Gene name | higA | Uniprot ID | - |
| Locus tag | C3F40_RS29995 | Protein ID | WP_000124640.1 |
| Coordinates | 6560..6862 (+) | Length | 101 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| C3F40_RS29950 | 1554..1910 | - | 357 | WP_103216125.1 | hypothetical protein | - |
| C3F40_RS29955 | 1999..2286 | + | 288 | WP_103216124.1 | metal-sensing transcriptional repressor | - |
| C3F40_RS29960 | 2295..3443 | + | 1149 | WP_103216123.1 | nickel/cobalt efflux protein RcnA | - |
| C3F40_RS29965 | 4114..4584 | - | 471 | WP_001281821.1 | hypothetical protein | - |
| C3F40_RS29970 | 4577..4948 | - | 372 | WP_000516916.1 | hypothetical protein | - |
| C3F40_RS29975 | 4959..5153 | - | 195 | WP_000343597.1 | hypothetical protein | - |
| C3F40_RS29985 | 5494..6042 | - | 549 | WP_001061574.1 | transcriptional regulator | - |
| C3F40_RS29990 | 6205..6555 | + | 351 | WP_000270043.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| C3F40_RS29995 | 6560..6862 | + | 303 | WP_000124640.1 | XRE family transcriptional regulator | Antitoxin |
| C3F40_RS30000 | 6889..7182 | - | 294 | WP_001239997.1 | chromosome segregation protein ParM | - |
| C3F40_RS30005 | 7270..7542 | - | 273 | WP_001043047.1 | HU family DNA-binding protein | - |
| C3F40_RS30010 | 7600..8127 | - | 528 | WP_001236377.1 | thermonuclease family protein | - |
| C3F40_RS30015 | 8144..8332 | - | 189 | WP_001270411.1 | hypothetical protein | - |
| C3F40_RS30020 | 8358..9215 | - | 858 | WP_001167032.1 | hypothetical protein | - |
| C3F40_RS30025 | 9202..9432 | - | 231 | WP_000972663.1 | hypothetical protein | - |
| C3F40_RS30030 | 9432..9950 | - | 519 | WP_000210756.1 | nitrite reductase | - |
| C3F40_RS30035 | 9947..10393 | - | 447 | WP_000919345.1 | Fe3+-siderophore ABC transporter permease | - |
| C3F40_RS30040 | 10393..10752 | - | 360 | WP_000422768.1 | hypothetical protein | - |
| C3F40_RS30045 | 10809..11237 | - | 429 | WP_000591074.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Conjugative plasmid | sul1 / mph(E) / msr(E) / qnrA1 / qacE / aadA2 | - | 1..186884 | 186884 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 117 a.a. Molecular weight: 13328.21 Da Isoelectric Point: 5.2421
>T94835 WP_000270043.1 NZ_CP026405:6205-6555 [Escherichia coli]
MWVIETTDTFDEWFDALDDTDRANVLASMMVLRDRGPMLSRPYADTVNGSSYSNMKELRVQSKGDPIRAFFAFDPKRKGI
LLCAGNKTGDEKRFYEVMIPIADREFAAHLDKLKKE
MWVIETTDTFDEWFDALDDTDRANVLASMMVLRDRGPMLSRPYADTVNGSSYSNMKELRVQSKGDPIRAFFAFDPKRKGI
LLCAGNKTGDEKRFYEVMIPIADREFAAHLDKLKKE
Download Length: 351 bp
>T94835 NZ_CP026405:6205-6555 [Escherichia coli]
ATGTGGGTCATCGAGACAACCGACACCTTTGATGAGTGGTTCGATGCTCTGGATGATACCGATAGAGCAAACGTGCTGGC
TTCGATGATGGTGCTGCGAGATAGAGGCCCCATGCTGTCGAGGCCATACGCGGATACTGTTAACGGTTCATCCTACAGCA
ACATGAAAGAGCTTCGGGTCCAAAGCAAAGGAGATCCTATCAGAGCGTTCTTTGCGTTCGATCCAAAGCGTAAGGGGATT
CTTCTCTGCGCCGGTAACAAGACCGGGGACGAGAAAAGGTTTTATGAAGTAATGATCCCAATTGCAGACCGTGAGTTTGC
GGCGCACTTGGATAAATTGAAGAAGGAGTGA
ATGTGGGTCATCGAGACAACCGACACCTTTGATGAGTGGTTCGATGCTCTGGATGATACCGATAGAGCAAACGTGCTGGC
TTCGATGATGGTGCTGCGAGATAGAGGCCCCATGCTGTCGAGGCCATACGCGGATACTGTTAACGGTTCATCCTACAGCA
ACATGAAAGAGCTTCGGGTCCAAAGCAAAGGAGATCCTATCAGAGCGTTCTTTGCGTTCGATCCAAAGCGTAAGGGGATT
CTTCTCTGCGCCGGTAACAAGACCGGGGACGAGAAAAGGTTTTATGAAGTAATGATCCCAATTGCAGACCGTGAGTTTGC
GGCGCACTTGGATAAATTGAAGAAGGAGTGA
Antitoxin
Download Length: 101 a.a. Molecular weight: 11006.73 Da Isoelectric Point: 7.2036
>AT94835 WP_000124640.1 NZ_CP026405:6560-6862 [Escherichia coli]
MARTLDQMLATEKPEVVAKAQKAATEMLLNIHLAELRDRMNLTQGEIAASLGVRQPTVSEMEKPGRDLKLSSIKRYVEAS
GGKLRLDVELPDGTHYGFAV
MARTLDQMLATEKPEVVAKAQKAATEMLLNIHLAELRDRMNLTQGEIAASLGVRQPTVSEMEKPGRDLKLSSIKRYVEAS
GGKLRLDVELPDGTHYGFAV
Download Length: 303 bp
>AT94835 NZ_CP026405:6560-6862 [Escherichia coli]
ATGGCAAGAACTCTTGACCAAATGCTGGCAACAGAAAAGCCTGAGGTTGTTGCCAAAGCACAGAAAGCGGCCACTGAGAT
GTTACTGAACATCCACTTGGCAGAGCTTCGTGATCGCATGAACCTTACCCAGGGGGAAATTGCTGCATCTCTGGGTGTGA
GACAGCCGACAGTCTCCGAGATGGAAAAACCTGGACGAGATCTCAAGCTGTCGTCCATTAAGCGGTACGTTGAGGCCTCC
GGTGGCAAGCTACGCCTCGATGTTGAACTTCCGGACGGCACCCACTACGGCTTTGCCGTTTAA
ATGGCAAGAACTCTTGACCAAATGCTGGCAACAGAAAAGCCTGAGGTTGTTGCCAAAGCACAGAAAGCGGCCACTGAGAT
GTTACTGAACATCCACTTGGCAGAGCTTCGTGATCGCATGAACCTTACCCAGGGGGAAATTGCTGCATCTCTGGGTGTGA
GACAGCCGACAGTCTCCGAGATGGAAAAACCTGGACGAGATCTCAAGCTGTCGTCCATTAAGCGGTACGTTGAGGCCTCC
GGTGGCAAGCTACGCCTCGATGTTGAACTTCCGGACGGCACCCACTACGGCTTTGCCGTTTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|