Detailed information of TA system TA094013

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): symE-ohsC/SymE(toxin)
• Location: 4579495..4579907
• Replicon: chromosome
• Accession: NZ_CP026345
• Organism: Escherichia coli strain 8A

Toxin (Protein)

• Gene name: symE
• Uniprot ID: U9YSY7
• Locus tag: C2R18_RS23675
• Protein ID: WP_000132601.1
• Coordinates: 4579495..4579836 (-)
• Length: 114 a.a.

Antitoxin (RNA)

Gene name	ohsC
Locus tag	-
Coordinates	4579831..4579907 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
C2R18_RS23665	4576908..4577954	-	1047	WP_000437621.1	5-methylcytosine-specific restriction endonuclease system specificity protein McrC	-
C2R18_RS23670	4577954..4579333	-	1380	WP_000443951.1	5-methylcytosine-specific restriction endonuclease subunit McrB	-
C2R18_RS23675	4579495..4579836	-	342	WP_000132601.1	endoribonuclease SymE	Toxin
-	4579831..4579907	+	77	NuclAT_14	-	Antitoxin
-	4579831..4579907	+	77	NuclAT_14	-	Antitoxin
-	4579831..4579907	+	77	NuclAT_14	-	Antitoxin
-	4579831..4579907	+	77	NuclAT_14	-	Antitoxin
-	4579831..4579907	+	77	NuclAT_15	-	Antitoxin
-	4579831..4579907	+	77	NuclAT_15	-	Antitoxin
-	4579831..4579907	+	77	NuclAT_15	-	Antitoxin
-	4579831..4579907	+	77	NuclAT_15	-	Antitoxin
C2R18_RS23680	4580064..4581458	-	1395	WP_001272447.1	type I restriction-modification system specificity subunit	-
C2R18_RS23685	4581455..4583044	-	1590	WP_001063204.1	type I restriction-modification system methyltransferase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin SymE-like (20-71)

Sequences

Toxin

Protein

• Length: 114 a.a.
• Molecular weight: 12203.02 Da
• Isoelectric Point: 8.5012

>T94013 WP_000132601.1 NZ_CP026345:c4579836-4579495 [Escherichia coli]
MTDTHSIAQPFEAEVSPANNRHVTVGYASRYPDYSRIPAITLKGQWLEAAGFATGTAVDVKVMEGCIVLTAQPPAAEESE
LMQSLRQVCKLSARKQKQVQAFIGVIAGKQKVA

Nucleotide

• Length: 342 bp

>T94013 NZ_CP026345:c4579836-4579495 [Escherichia coli]
ATGACTGACACGCATTCTATTGCACAACCGTTCGAAGCAGAAGTCTCCCCGGCAAATAACCGTCATGTCACCGTCGGTTA
TGCGAGTCGCTACCCGGATTACAGCCGTATTCCCGCCATCACCCTGAAAGGTCAGTGGCTGGAAGCCGCCGGTTTTGCCA
CTGGCACGGCGGTAGATGTCAAAGTGATGGAAGGCTGTATTGTCCTCACCGCCCAACCACCCGCCGCCGAGGAGAGCGAA
CTGATGCAGTCGCTACGCCAGGTGTGCAAACTGTCGGCGCGTAAACAAAAGCAGGTGCAGGCGTTTATTGGAGTGATTGC
CGGTAAACAGAAAGTCGCGTAA

Antitoxin

Nucleotide

• Length: 77 bp

>AT94013 NZ_CP026345:4579831-4579907 [Escherichia coli]
AGTCATAACTGCTATTCTCCAGGAATAGTGATTGTGATTAGCGATGCGGGTGTGTTGGCGCACATCCGCACCGCGCT

Structures

Toxin

• AlphaFold DB: U9YSY7

Antitoxin