93759

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 81045..81695 Replicon chromosome
Accession NZ_CP026269
Organism Klebsiella oxytoca strain KONIH4

Toxin (Protein)


Gene name higB Uniprot ID A0A0H3H3K0
Locus tag C2U44_RS00400 Protein ID WP_014227314.1
Coordinates 81045..81386 (+) Length 114 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A0H3H3Q5
Locus tag C2U44_RS00405 Protein ID WP_014227313.1
Coordinates 81396..81695 (+) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C2U44_RS00380 77037..78356 + 1320 WP_032751824.1 MFS transporter -
C2U44_RS00385 78502..79893 + 1392 WP_004107098.1 hexose-6-phosphate:phosphate antiporter -
C2U44_RS00395 80342..80794 + 453 WP_032718748.1 DUF1198 domain-containing protein -
C2U44_RS00400 81045..81386 + 342 WP_014227314.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
C2U44_RS00405 81396..81695 + 300 WP_014227313.1 helix-turn-helix transcriptional regulator Antitoxin
C2U44_RS00410 81814..82995 + 1182 WP_014227312.1 purine ribonucleoside efflux pump NepI -
C2U44_RS00415 83028..83837 - 810 WP_004855618.1 phosphonoacetaldehyde hydrolase -
C2U44_RS00420 83847..84950 - 1104 WP_014227310.1 2-aminoethylphosphonate--pyruvate transaminase -
C2U44_RS00425 85091..85810 + 720 WP_042946139.1 phosphonate utilization transcriptional regulator PhnR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(12-107)

Antitoxin

Cro/C1-type helix-turn-helix domain

(31-84)


Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 13110.00 Da        Isoelectric Point: 5.7545

>T93759 WP_014227314.1 NZ_CP026269:81045-81386 [Klebsiella oxytoca]
MWDVETTEVFDKWFEAQTEALKEDMLAAMVILSEYGPRLGRPFADTVNDSAFSNMKELRIQHQGRPIRAFFVFDPSRCGI
VLCAGDKTGLNEKRFYKDMIKLADAEYRKHLNQ

Download         Length: 342 bp

>T93759 NZ_CP026269:81045-81386 [Klebsiella oxytoca]
ATGTGGGATGTTGAAACAACGGAGGTTTTTGACAAGTGGTTTGAGGCGCAGACCGAAGCGCTCAAAGAGGATATGCTCGC
CGCAATGGTGATCTTATCCGAGTATGGCCCCCGGTTGGGAAGGCCGTTTGCGGATACAGTAAACGATTCTGCCTTTTCGA
ATATGAAAGAGCTGCGCATTCAGCATCAAGGTAGACCCATCCGAGCTTTCTTTGTATTTGACCCTTCTCGTTGTGGCATC
GTGTTATGCGCCGGAGATAAAACAGGGTTAAATGAAAAGAGATTCTATAAAGATATGATCAAGCTTGCAGATGCTGAGTA
CCGTAAGCACCTTAATCAGTAA

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 10966.87 Da        Isoelectric Point: 9.7256

>AT93759 WP_014227313.1 NZ_CP026269:81396-81695 [Klebsiella oxytoca]
MATLKELMAKQSPESQARIAEKVEEMRQAIALSMLREELNMSQAELAKAMGVKQPTIAKMEQADNDPRLSTLKRYVAALG
GELSIDVKLPTGKRIAFHL

Download         Length: 300 bp

>AT93759 NZ_CP026269:81396-81695 [Klebsiella oxytoca]
ATGGCGACCCTTAAAGAATTAATGGCCAAACAGAGCCCGGAAAGCCAGGCGCGTATTGCTGAAAAAGTCGAGGAGATGCG
CCAGGCTATCGCTTTAAGTATGTTAAGGGAAGAACTCAATATGTCTCAGGCAGAGCTGGCTAAGGCAATGGGCGTTAAAC
AACCCACCATAGCAAAAATGGAACAGGCTGATAACGACCCGCGTTTGTCAACGCTGAAGCGCTATGTTGCAGCGCTCGGG
GGGGAACTCAGTATTGATGTTAAGCTGCCAACCGGTAAGCGAATCGCATTCCATCTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3H3K0

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3H3Q5

References