Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 4015347..4016080 Replicon chromosome
Accession NZ_CP026217
Organism Aeromonas sp. ASNIH4

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag C2U40_RS18645 Protein ID WP_103827431.1
Coordinates 4015347..4015658 (+) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag C2U40_RS18650 Protein ID WP_103827430.1
Coordinates 4015664..4016080 (+) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C2U40_RS18610 4010601..4010858 + 258 WP_103827437.1 hypothetical protein -
C2U40_RS18615 4010855..4013188 + 2334 WP_181014758.1 replication endonuclease -
C2U40_RS18620 4013462..4013953 + 492 WP_103827436.1 hypothetical protein -
C2U40_RS18625 4013956..4014183 + 228 WP_103827435.1 hypothetical protein -
C2U40_RS18635 4014395..4014871 + 477 WP_103827433.1 DUF3850 domain-containing protein -
C2U40_RS18640 4014871..4015203 + 333 WP_103827432.1 hypothetical protein -
C2U40_RS18645 4015347..4015658 + 312 WP_103827431.1 type II toxin-antitoxin system HigB family toxin Toxin
C2U40_RS18650 4015664..4016080 + 417 WP_103827430.1 transcriptional regulator Antitoxin
C2U40_RS18655 4016107..4016358 - 252 WP_103827470.1 ogr/Delta-like zinc finger family protein -
C2U40_RS18660 4016418..4017431 - 1014 WP_103827429.1 phage portal protein -
C2U40_RS18665 4017428..4018201 - 774 WP_103827428.1 terminase family protein -
C2U40_RS18670 4018198..4020018 - 1821 WP_103827427.1 terminase family protein -
C2U40_RS18675 4020195..4021052 + 858 WP_103827426.1 GPO family capsid scaffolding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 4004656..4037920 33264


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, mRNA interferase HigB

(21-93)

Antitoxin

Antitoxin HigA

(6-138)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12331.01 Da        Isoelectric Point: 9.6064

>T93715 WP_103827431.1 NZ_CP026217:4015347-4015658 [Aeromonas sp. ASNIH4]
VHVLSRKPFNDAAKLYPNDSEALVHVYTTLRTGDFSAPDELRKVFPNLDNFKYRDKWWVIDIGGNNLRLIAFIEFRDNRM
YVKHIVSHAEYDKLTEKYRRNKE

Download         Length: 312 bp

>T93715 NZ_CP026217:4015347-4015658 [Aeromonas sp. ASNIH4]
GTGCACGTACTATCTCGCAAGCCATTTAATGACGCTGCCAAGCTCTATCCCAACGACAGTGAAGCCTTGGTGCATGTGTA
CACAACGTTGCGCACTGGTGATTTCTCAGCACCTGATGAACTGAGGAAGGTGTTTCCCAACCTTGATAACTTCAAGTATC
GAGACAAGTGGTGGGTGATCGATATCGGTGGCAATAACCTGCGCCTGATCGCCTTCATTGAGTTCAGGGATAACCGCATG
TATGTGAAACACATTGTCAGCCATGCCGAATACGACAAGCTGACCGAGAAGTACCGGAGAAACAAGGAGTAA

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15344.50 Da        Isoelectric Point: 4.5413

>AT93715 WP_103827430.1 NZ_CP026217:4015664-4016080 [Aeromonas sp. ASNIH4]
MLNLALVQIREALAQVPYITQINNQDDYEQALELMDELVDDYGANKQLVELLATSIEHWEDKADEFAEFNKAVAGVEPGI
AVLKTLMNQHHLGVADLPELGSKSNVSKLLNAAEGKKLTRQHIEALSKRFALSPALFF

Download         Length: 417 bp

>AT93715 NZ_CP026217:4015664-4016080 [Aeromonas sp. ASNIH4]
ATGTTAAATCTTGCGCTGGTTCAGATTAGAGAGGCATTGGCCCAAGTGCCATACATCACCCAGATCAATAATCAGGACGA
TTATGAGCAAGCTCTTGAGCTGATGGACGAGCTGGTCGACGACTATGGCGCCAACAAGCAATTGGTTGAGTTGCTGGCGA
CCAGCATCGAGCACTGGGAAGACAAGGCCGACGAGTTCGCCGAGTTCAACAAGGCGGTGGCAGGCGTAGAGCCGGGCATA
GCCGTGTTGAAAACGCTGATGAACCAACACCATCTGGGGGTAGCTGACCTGCCGGAGCTGGGATCAAAATCCAACGTGAG
CAAACTGCTCAACGCAGCCGAGGGTAAAAAGCTGACCCGCCAACACATTGAGGCGCTGAGCAAGCGCTTTGCTCTCTCCC
CTGCGCTTTTCTTTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References