Detailed information of TA system TA093715

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/HigB-HigA
• Location: 4015347..4016080
• Replicon: chromosome
• Accession: NZ_CP026217
• Organism: Aeromonas sp. ASNIH4

Toxin (Protein)

• Gene name: higB
• Uniprot ID: -
• Locus tag: C2U40_RS18645
• Protein ID: WP_103827431.1
• Coordinates: 4015347..4015658 (+)
• Length: 104 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: C2U40_RS18650
• Protein ID: WP_103827430.1
• Coordinates: 4015664..4016080 (+)
• Length: 139 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
C2U40_RS18610	4010601..4010858	+	258	WP_103827437.1	hypothetical protein	-
C2U40_RS18615	4010855..4013188	+	2334	WP_181014758.1	replication endonuclease	-
C2U40_RS18620	4013462..4013953	+	492	WP_103827436.1	hypothetical protein	-
C2U40_RS18625	4013956..4014183	+	228	WP_103827435.1	hypothetical protein	-
C2U40_RS18635	4014395..4014871	+	477	WP_103827433.1	DUF3850 domain-containing protein	-
C2U40_RS18640	4014871..4015203	+	333	WP_103827432.1	hypothetical protein	-
C2U40_RS18645	4015347..4015658	+	312	WP_103827431.1	type II toxin-antitoxin system HigB family toxin	Toxin
C2U40_RS18650	4015664..4016080	+	417	WP_103827430.1	transcriptional regulator	Antitoxin
C2U40_RS18655	4016107..4016358	-	252	WP_103827470.1	ogr/Delta-like zinc finger family protein	-
C2U40_RS18660	4016418..4017431	-	1014	WP_103827429.1	phage portal protein	-
C2U40_RS18665	4017428..4018201	-	774	WP_103827428.1	terminase family protein	-
C2U40_RS18670	4018198..4020018	-	1821	WP_103827427.1	terminase family protein	-
C2U40_RS18675	4020195..4021052	+	858	WP_103827426.1	GPO family capsid scaffolding protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	4004656..4037920	33264

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, mRNA interferase HigB (21-93)

Antitoxin

• Antitoxin HigA (6-138)

Sequences

Toxin

Protein

• Length: 104 a.a.
• Molecular weight: 12331.01 Da
• Isoelectric Point: 9.6064

>T93715 WP_103827431.1 NZ_CP026217:4015347-4015658 [Aeromonas sp. ASNIH4]
VHVLSRKPFNDAAKLYPNDSEALVHVYTTLRTGDFSAPDELRKVFPNLDNFKYRDKWWVIDIGGNNLRLIAFIEFRDNRM
YVKHIVSHAEYDKLTEKYRRNKE

Nucleotide

• Length: 312 bp

>T93715 NZ_CP026217:4015347-4015658 [Aeromonas sp. ASNIH4]
GTGCACGTACTATCTCGCAAGCCATTTAATGACGCTGCCAAGCTCTATCCCAACGACAGTGAAGCCTTGGTGCATGTGTA
CACAACGTTGCGCACTGGTGATTTCTCAGCACCTGATGAACTGAGGAAGGTGTTTCCCAACCTTGATAACTTCAAGTATC
GAGACAAGTGGTGGGTGATCGATATCGGTGGCAATAACCTGCGCCTGATCGCCTTCATTGAGTTCAGGGATAACCGCATG
TATGTGAAACACATTGTCAGCCATGCCGAATACGACAAGCTGACCGAGAAGTACCGGAGAAACAAGGAGTAA

Antitoxin

Protein

• Length: 139 a.a.
• Molecular weight: 15344.50 Da
• Isoelectric Point: 4.5413

>AT93715 WP_103827430.1 NZ_CP026217:4015664-4016080 [Aeromonas sp. ASNIH4]
MLNLALVQIREALAQVPYITQINNQDDYEQALELMDELVDDYGANKQLVELLATSIEHWEDKADEFAEFNKAVAGVEPGI
AVLKTLMNQHHLGVADLPELGSKSNVSKLLNAAEGKKLTRQHIEALSKRFALSPALFF

Nucleotide

• Length: 417 bp

>AT93715 NZ_CP026217:4015664-4016080 [Aeromonas sp. ASNIH4]
ATGTTAAATCTTGCGCTGGTTCAGATTAGAGAGGCATTGGCCCAAGTGCCATACATCACCCAGATCAATAATCAGGACGA
TTATGAGCAAGCTCTTGAGCTGATGGACGAGCTGGTCGACGACTATGGCGCCAACAAGCAATTGGTTGAGTTGCTGGCGA
CCAGCATCGAGCACTGGGAAGACAAGGCCGACGAGTTCGCCGAGTTCAACAAGGCGGTGGCAGGCGTAGAGCCGGGCATA
GCCGTGTTGAAAACGCTGATGAACCAACACCATCTGGGGGTAGCTGACCTGCCGGAGCTGGGATCAAAATCCAACGTGAG
CAAACTGCTCAACGCAGCCGAGGGTAAAAAGCTGACCCGCCAACACATTGAGGCGCTGAGCAAGCGCTTTGCTCTCTCCC
CTGCGCTTTTCTTTTGA