Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 560732..561384 Replicon chromosome
Accession NZ_CP026217
Organism Aeromonas sp. ASNIH4

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag C2U40_RS02630 Protein ID WP_103828992.1
Coordinates 560732..561082 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag C2U40_RS02635 Protein ID WP_042046566.1
Coordinates 561082..561384 (+) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C2U40_RS02615 558879..559337 - 459 WP_103828989.1 hypothetical protein -
C2U40_RS25980 559344..559742 - 399 WP_146054403.1 hypothetical protein -
C2U40_RS02625 559734..560684 + 951 WP_103828991.1 DUF932 domain-containing protein -
C2U40_RS02630 560732..561082 + 351 WP_103828992.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
C2U40_RS02635 561082..561384 + 303 WP_042046566.1 XRE family transcriptional regulator Antitoxin
C2U40_RS02640 561561..562562 + 1002 WP_103828993.1 YqaJ viral recombinase family protein -
C2U40_RS02645 562559..563497 + 939 WP_029303610.1 hypothetical protein -
C2U40_RS02650 563499..563846 - 348 WP_029303609.1 helix-turn-helix domain-containing protein -
C2U40_RS02660 564329..564520 + 192 WP_146054404.1 hypothetical protein -
C2U40_RS02665 564761..565249 + 489 WP_103829000.1 hypothetical protein -
C2U40_RS02670 565334..565894 + 561 WP_029303605.1 lecithin retinol acyltransferase family protein -
C2U40_RS02675 565932..566357 + 426 WP_029303604.1 DUF2787 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - htpB 493264..603942 110678


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(12-106)

Antitoxin

Cro/C1-type helix-turn-helix domain

(32-81)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 13075.07 Da        Isoelectric Point: 8.0312

>T93713 WP_103828992.1 NZ_CP026217:560732-561082 [Aeromonas sp. ASNIH4]
MWTVKTTELFNAWFDVQDEATQEKVLAGLLALAQGGPSVGRPLVDTIKGSRFTNLKELRVQHQGEPLRAFFAFDPLRQAI
VLCAGKKGGNEKRFYKEMLPLAEAQYARHLAELEEK

Download         Length: 351 bp

>T93713 NZ_CP026217:560732-561082 [Aeromonas sp. ASNIH4]
ATGTGGACAGTAAAAACGACCGAGCTGTTTAATGCTTGGTTTGATGTGCAAGATGAAGCGACGCAGGAGAAAGTCTTGGC
TGGGCTACTCGCCTTGGCACAAGGTGGCCCATCGGTAGGGCGTCCCCTGGTCGATACCATCAAGGGCTCGCGTTTTACAA
ACTTAAAAGAGCTGAGGGTGCAGCATCAGGGAGAGCCGCTACGTGCATTCTTTGCCTTTGACCCGCTGCGACAAGCCATC
GTGCTTTGTGCTGGCAAAAAGGGCGGGAACGAGAAGCGGTTTTACAAAGAGATGCTGCCGTTGGCTGAGGCACAGTACGC
CAGGCATCTGGCTGAGTTGGAGGAAAAGTAA

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11179.90 Da        Isoelectric Point: 5.2187

>AT93713 WP_042046566.1 NZ_CP026217:561082-561384 [Aeromonas sp. ASNIH4]
MGRTLDDLLASRSEESRQRIQEMATELLLEVRIQALREELEVSQVELAKALGVSQPAVVAMEQRGSDIKLSTMKRYVEAM
GGKLRVDVELPTGRHIGFNV

Download         Length: 303 bp

>AT93713 NZ_CP026217:561082-561384 [Aeromonas sp. ASNIH4]
ATGGGAAGAACACTTGACGATTTGCTGGCCTCCCGTTCAGAAGAGAGTCGGCAACGCATCCAGGAAATGGCAACCGAGCT
GTTGCTGGAGGTGCGTATACAGGCGCTGCGCGAAGAGCTGGAGGTGTCGCAGGTTGAGTTGGCTAAGGCACTCGGTGTCA
GTCAGCCTGCCGTCGTGGCGATGGAGCAGCGTGGCAGTGATATCAAGCTCTCCACCATGAAACGCTATGTTGAAGCGATG
GGCGGCAAGCTGCGTGTAGATGTGGAATTGCCTACCGGCCGACACATCGGGTTCAACGTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References