Detailed information of TA system TA093713

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/COG4683-HTH_37
• Location: 560732..561384
• Replicon: chromosome
• Accession: NZ_CP026217
• Organism: Aeromonas sp. ASNIH4

Toxin (Protein)

• Gene name: higB
• Uniprot ID: -
• Locus tag: C2U40_RS02630
• Protein ID: WP_103828992.1
• Coordinates: 560732..561082 (+)
• Length: 117 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: C2U40_RS02635
• Protein ID: WP_042046566.1
• Coordinates: 561082..561384 (+)
• Length: 101 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
C2U40_RS02615	558879..559337	-	459	WP_103828989.1	hypothetical protein	-
C2U40_RS25980	559344..559742	-	399	WP_146054403.1	hypothetical protein	-
C2U40_RS02625	559734..560684	+	951	WP_103828991.1	DUF932 domain-containing protein	-
C2U40_RS02630	560732..561082	+	351	WP_103828992.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
C2U40_RS02635	561082..561384	+	303	WP_042046566.1	XRE family transcriptional regulator	Antitoxin
C2U40_RS02640	561561..562562	+	1002	WP_103828993.1	YqaJ viral recombinase family protein	-
C2U40_RS02645	562559..563497	+	939	WP_029303610.1	hypothetical protein	-
C2U40_RS02650	563499..563846	-	348	WP_029303609.1	helix-turn-helix domain-containing protein	-
C2U40_RS02660	564329..564520	+	192	WP_146054404.1	hypothetical protein	-
C2U40_RS02665	564761..565249	+	489	WP_103829000.1	hypothetical protein	-
C2U40_RS02670	565334..565894	+	561	WP_029303605.1	lecithin retinol acyltransferase family protein	-
C2U40_RS02675	565932..566357	+	426	WP_029303604.1	DUF2787 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	htpB	493264..603942	110678

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-like (12-106)

Antitoxin

• Cro/C1-type helix-turn-helix domain (32-81)

Sequences

Toxin

Protein

• Length: 117 a.a.
• Molecular weight: 13075.07 Da
• Isoelectric Point: 8.0312

>T93713 WP_103828992.1 NZ_CP026217:560732-561082 [Aeromonas sp. ASNIH4]
MWTVKTTELFNAWFDVQDEATQEKVLAGLLALAQGGPSVGRPLVDTIKGSRFTNLKELRVQHQGEPLRAFFAFDPLRQAI
VLCAGKKGGNEKRFYKEMLPLAEAQYARHLAELEEK

Nucleotide

• Length: 351 bp

>T93713 NZ_CP026217:560732-561082 [Aeromonas sp. ASNIH4]
ATGTGGACAGTAAAAACGACCGAGCTGTTTAATGCTTGGTTTGATGTGCAAGATGAAGCGACGCAGGAGAAAGTCTTGGC
TGGGCTACTCGCCTTGGCACAAGGTGGCCCATCGGTAGGGCGTCCCCTGGTCGATACCATCAAGGGCTCGCGTTTTACAA
ACTTAAAAGAGCTGAGGGTGCAGCATCAGGGAGAGCCGCTACGTGCATTCTTTGCCTTTGACCCGCTGCGACAAGCCATC
GTGCTTTGTGCTGGCAAAAAGGGCGGGAACGAGAAGCGGTTTTACAAAGAGATGCTGCCGTTGGCTGAGGCACAGTACGC
CAGGCATCTGGCTGAGTTGGAGGAAAAGTAA

Antitoxin

Protein

• Length: 101 a.a.
• Molecular weight: 11179.90 Da
• Isoelectric Point: 5.2187

>AT93713 WP_042046566.1 NZ_CP026217:561082-561384 [Aeromonas sp. ASNIH4]
MGRTLDDLLASRSEESRQRIQEMATELLLEVRIQALREELEVSQVELAKALGVSQPAVVAMEQRGSDIKLSTMKRYVEAM
GGKLRVDVELPTGRHIGFNV

Nucleotide

• Length: 303 bp

>AT93713 NZ_CP026217:561082-561384 [Aeromonas sp. ASNIH4]
ATGGGAAGAACACTTGACGATTTGCTGGCCTCCCGTTCAGAAGAGAGTCGGCAACGCATCCAGGAAATGGCAACCGAGCT
GTTGCTGGAGGTGCGTATACAGGCGCTGCGCGAAGAGCTGGAGGTGTCGCAGGTTGAGTTGGCTAAGGCACTCGGTGTCA
GTCAGCCTGCCGTCGTGGCGATGGAGCAGCGTGGCAGTGATATCAAGCTCTCCACCATGAAACGCTATGTTGAAGCGATG
GGCGGCAAGCTGCGTGTAGATGTGGAATTGCCTACCGGCCGACACATCGGGTTCAACGTCTGA