Detailed information of TA system TA093702

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/HigB-HigA
• Location: 3807295..3807857
• Replicon: chromosome
• Accession: NZ_CP026216
• Organism: Citrobacter sp. CFNIH10

Toxin (Protein)

• Gene name: higB
• Uniprot ID: A0A3S7DBL2
• Locus tag: C2U53_RS22190
• Protein ID: WP_043000694.1
• Coordinates: 3807295..3807573 (+)
• Length: 93 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: C2U53_RS22195
• Protein ID: WP_043000693.1
• Coordinates: 3807573..3807857 (+)
• Length: 95 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
C2U53_RS22170	3802420..3802851	-	432	WP_043000697.1	peroxiredoxin OsmC	-
C2U53_RS22175	3803079..3803222	+	144	WP_042319017.1	stationary-phase-induced ribosome-associated protein	-
C2U53_RS22180	3803394..3805091	+	1698	WP_044257943.1	malate dehydrogenase	-
C2U53_RS22185	3805400..3807115	+	1716	WP_104446452.1	ATP-binding cassette domain-containing protein	-
C2U53_RS22190	3807295..3807573	+	279	WP_043000694.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
C2U53_RS22195	3807573..3807857	+	285	WP_043000693.1	HigA family addiction module antidote protein	Antitoxin
C2U53_RS22200	3807902..3808504	-	603	WP_044257938.1	inorganic diphosphatase	-
C2U53_RS22205	3808631..3809287	-	657	WP_043000691.1	formate dehydrogenase-N subunit gamma	-
C2U53_RS22210	3809280..3810215	-	936	WP_104446453.1	formate dehydrogenase subunit beta	-
C2U53_RS22220	3810163..3812739	+	2577	Protein_3574	formate dehydrogenase-N subunit alpha	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-1 (4-92)

Antitoxin

• Toxin-antitoxin system, antidote protein, HigA (1-83)

Sequences

Toxin

Protein

• Length: 93 a.a.
• Molecular weight: 10573.12 Da
• Isoelectric Point: 8.9461

>T93702 WP_043000694.1 NZ_CP026216:3807295-3807573 [Citrobacter sp. CFNIH10]
MIMNFRHKGLRDLFLHGKTSGVLAKHVKRLRHRLAVIDAAGCVNDINMPGYRLHPLSGDRDGVWSISVSGNWRMTFEFVN
GDAYILDYEDYH

Nucleotide

• Length: 279 bp

>T93702 NZ_CP026216:3807295-3807573 [Citrobacter sp. CFNIH10]
ATGATCATGAATTTCAGGCACAAGGGATTACGCGACCTGTTTCTTCACGGTAAAACGTCAGGCGTGCTGGCAAAGCACGT
CAAACGTTTGCGACACCGCCTCGCCGTGATTGACGCCGCAGGCTGCGTGAACGATATCAACATGCCCGGTTATCGGCTGC
ATCCTCTGAGCGGCGATCGTGATGGCGTCTGGTCAATATCGGTTTCAGGCAACTGGCGTATGACGTTCGAATTCGTCAAT
GGCGATGCGTATATTCTGGATTACGAGGATTATCACTGA

Antitoxin

Protein

• Length: 95 a.a.
• Molecular weight: 10370.07 Da
• Isoelectric Point: 10.2982

>AT93702 WP_043000693.1 NZ_CP026216:3807573-3807857 [Citrobacter sp. CFNIH10]
MKMANHPRPGDIIQEALDELNVSLREFARAMEIAPSTASRLLTGKAALTPEMAIKLSVVIGSSPEMWLNLQNTWSLAQAQ
KSVDVSRLRRLAVQ

Nucleotide

• Length: 285 bp

>AT93702 NZ_CP026216:3807573-3807857 [Citrobacter sp. CFNIH10]
ATGAAAATGGCGAATCATCCCCGCCCAGGGGATATCATTCAGGAAGCGCTGGACGAACTGAACGTCAGTTTGCGTGAATT
TGCCAGAGCAATGGAGATTGCGCCCTCAACCGCCAGTCGGTTACTCACGGGCAAAGCGGCACTCACCCCGGAAATGGCGA
TCAAACTCTCGGTGGTGATCGGCAGCTCCCCGGAAATGTGGCTAAATCTGCAAAATACCTGGAGTCTGGCACAAGCGCAA
AAAAGCGTGGACGTGTCCCGTTTGCGCCGTCTGGCGGTGCAGTAA

Structures

Toxin

• AlphaFold DB: A0A3S7DBL2