Detailed information of TA system TA093348

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/HigB-HigA
• Location: 324079..324797
• Replicon: chromosome
• Accession: NZ_CP026124
• Organism: Achromobacter sp. AONIH1

Toxin (Protein)

• Gene name: higB
• Uniprot ID: -
• Locus tag: C2U31_RS01440
• Protein ID: WP_103271234.1
• Coordinates: 324079..324360 (+)
• Length: 94 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: C2U31_RS01445
• Protein ID: WP_103271235.1
• Coordinates: 324348..324797 (+)
• Length: 150 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
C2U31_RS01415	319164..320573	-	1410	WP_103271230.1	DKNYY domain-containing protein	-
C2U31_RS01420	320768..322159	+	1392	WP_103271231.1	uracil-xanthine permease family protein	-
C2U31_RS01430	322919..323218	-	300	WP_103271232.1	type II toxin-antitoxin system RelE/ParE family toxin	-
C2U31_RS01435	323208..323456	-	249	WP_103271233.1	type II toxin-antitoxin system Phd/YefM family antitoxin	-
C2U31_RS30405	323513..323884	-	372	WP_158658286.1	hypothetical protein	-
C2U31_RS01440	324079..324360	+	282	WP_103271234.1	type II toxin-antitoxin system HigB family toxin	Toxin
C2U31_RS01445	324348..324797	+	450	WP_103271235.1	transcriptional regulator	Antitoxin
C2U31_RS01450	324944..325960	+	1017	WP_103271236.1	amino acid ABC transporter substrate-binding protein	-
C2U31_RS01455	326142..326423	+	282	WP_103271237.1	peptidylprolyl isomerase	-
C2U31_RS01460	326491..327135	-	645	WP_103271238.1	TetR/AcrR family transcriptional regulator	-
C2U31_RS01465	327358..329136	+	1779	WP_103271239.1	ABC transporter ATP-binding protein/permease	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	-	bauD / bauC / bauE / adeG	323706..500403	176697

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, mRNA interferase HigB (20-90)

Antitoxin

• Cro/C1-type helix-turn-helix domain (88-142)

Sequences

Toxin

Protein

• Length: 94 a.a.
• Molecular weight: 10939.57 Da
• Isoelectric Point: 10.1381

>T93348 WP_103271234.1 NZ_CP026124:324079-324360 [Achromobacter sp. AONIH1]
MHIISKQALREFWAYHPGSANALAHWHTTLMHARAADFSMLKRVFNTVDWVNGYVVFNVGGNKYRIVADIMFRSQTVFIK
HVFTHKEYDSWQP

Nucleotide

• Length: 282 bp

>T93348 NZ_CP026124:324079-324360 [Achromobacter sp. AONIH1]
ATGCACATCATCTCCAAGCAAGCATTGCGCGAGTTCTGGGCATATCACCCCGGATCCGCCAATGCGCTGGCCCATTGGCA
TACCACACTGATGCATGCCCGGGCCGCCGATTTCTCGATGCTGAAGAGGGTGTTCAACACCGTCGACTGGGTTAATGGAT
ACGTTGTTTTCAACGTCGGGGGCAACAAGTACCGCATCGTTGCCGACATCATGTTCCGGTCGCAAACCGTCTTCATCAAG
CATGTCTTTACGCACAAGGAGTACGACTCATGGCAGCCGTAA

Antitoxin

Protein

• Length: 150 a.a.
• Molecular weight: 16373.42 Da
• Isoelectric Point: 5.2050

>AT93348 WP_103271235.1 NZ_CP026124:324348-324797 [Achromobacter sp. AONIH1]
MAAVIPHLAELARSYDAFRTVAGVGAIRSEADHRRALALIEAILDETRDTPAREDASHPLADLLDLLTAAVHEYEADHYA
IPVSSPREVLRFLMDQHGLTQSDLPEVGSQSVISEILAGRRTFNTRQIAALVQRFHVAADAFIEHDAAR

Nucleotide

• Length: 450 bp

>AT93348 NZ_CP026124:324348-324797 [Achromobacter sp. AONIH1]
ATGGCAGCCGTAATCCCCCATCTGGCCGAATTGGCCCGCAGTTATGACGCATTCCGCACGGTGGCGGGCGTAGGCGCGAT
CCGTAGCGAAGCAGATCACCGCCGCGCCTTGGCGTTGATTGAAGCCATTCTGGACGAAACCCGCGACACGCCCGCGCGCG
AAGACGCCTCGCATCCGCTGGCCGATCTGCTGGATCTGTTGACGGCGGCAGTGCATGAGTACGAGGCCGACCACTACGCC
ATCCCGGTCTCATCGCCCCGTGAGGTGCTGCGCTTCCTGATGGATCAGCATGGGCTCACTCAGTCCGACCTGCCCGAAGT
CGGTAGTCAAAGCGTGATCTCCGAGATCCTGGCAGGACGCAGGACGTTCAATACCCGGCAGATTGCCGCCCTGGTGCAAC
GATTCCATGTAGCTGCTGACGCCTTCATCGAGCACGATGCCGCGCGCTAG