Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/MqsA(antitoxin)
Location 2205713..2206381 Replicon chromosome
Accession NZ_CP026102
Organism Paraburkholderia caribensis strain DSM 13236

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag C2L66_RS26470 Protein ID WP_060605493.1
Coordinates 2206040..2206381 (-) Length 114 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag C2L66_RS26465 Protein ID WP_060605496.1
Coordinates 2205713..2206024 (-) Length 104 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C2L66_RS26455 2201960..2203243 + 1284 WP_054933746.1 4-aminobutyrate--2-oxoglutarate transaminase -
C2L66_RS40830 2203915..2204124 - 210 WP_148654612.1 hypothetical protein -
C2L66_RS26460 2204152..2205618 + 1467 WP_054933743.1 NAD-dependent succinate-semialdehyde dehydrogenase -
C2L66_RS26465 2205713..2206024 - 312 WP_060605496.1 helix-turn-helix domain-containing protein Antitoxin
C2L66_RS26470 2206040..2206381 - 342 WP_060605493.1 hypothetical protein Toxin
C2L66_RS26475 2206636..2207610 - 975 WP_060605490.1 lipoyl synthase -
C2L66_RS26480 2207613..2208725 - 1113 WP_060605486.1 acetoin dehydrogenase dihydrolipoyllysine-residue acetyltransferase subunit -
C2L66_RS26485 2208741..2209745 - 1005 WP_060605483.1 alpha-ketoacid dehydrogenase subunit beta -
C2L66_RS26490 2209784..2210761 - 978 WP_054933738.1 thiamine pyrophosphate-dependent dehydrogenase E1 component subunit alpha -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(41-87)


Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 13194.11 Da        Isoelectric Point: 9.6373

>T93320 WP_060605493.1 NZ_CP026102:c2206381-2206040 [Paraburkholderia caribensis]
VAATFVELGPFRRWRDDYLTDDEYRALQIVLMQNPEAGDVIRGTGGLRKLRFGDARRGKGKRGGLRVIYYYWVKGPEFWM
FTLYDKDEAEDLSSKERGVLSEMLREVIKLANR

Download         Length: 342 bp

>T93320 NZ_CP026102:c2206381-2206040 [Paraburkholderia caribensis]
GTGGCGGCGACTTTCGTCGAGCTAGGCCCATTTCGCCGGTGGCGGGACGACTATCTGACGGACGACGAATATCGCGCGCT
TCAGATTGTGCTGATGCAGAACCCGGAAGCAGGGGATGTCATCAGGGGAACGGGTGGGCTGCGCAAACTCCGTTTCGGCG
ACGCACGGCGCGGGAAGGGAAAGCGCGGCGGGCTCAGGGTGATCTACTACTACTGGGTAAAGGGCCCCGAGTTCTGGATG
TTCACGCTGTACGACAAGGACGAAGCTGAAGACCTGTCGTCGAAGGAACGAGGGGTTCTCTCCGAGATGCTGAGAGAAGT
CATCAAGCTTGCGAATCGATAA

Antitoxin


Download         Length: 104 a.a.        Molecular weight: 11827.65 Da        Isoelectric Point: 9.7238

>AT93320 WP_060605496.1 NZ_CP026102:c2206024-2205713 [Paraburkholderia caribensis]
MKRNLLAELTEGLEELKSAHEGKTTLHKVKVEIRDKLEVTAEEIRAVRESINASQAVMARRLRVNERTYQNWEQGRAKPN
AQAAVLIKLVEKHPETIQMLETL

Download         Length: 312 bp

>AT93320 NZ_CP026102:c2206024-2205713 [Paraburkholderia caribensis]
ATGAAACGGAATCTGTTAGCCGAATTGACGGAAGGGCTCGAAGAACTCAAGTCCGCTCACGAAGGCAAGACCACACTTCA
CAAGGTCAAGGTTGAGATTCGTGACAAGCTGGAAGTAACGGCCGAGGAGATCCGTGCCGTCCGCGAATCCATCAACGCGT
CACAGGCGGTCATGGCACGCCGTCTGCGCGTGAACGAGCGGACGTACCAGAATTGGGAGCAAGGGAGGGCGAAACCGAAC
GCTCAGGCTGCCGTGCTGATCAAGCTGGTTGAAAAGCATCCTGAGACGATCCAGATGCTCGAAACCTTATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References