Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) DinJ-YafQ (relBE)/YafQ-DinJ
Location 1306207..1306771 Replicon chromosome
Accession NZ_CP026097
Organism Lacticaseibacillus paracasei strain HDS-01

Toxin (Protein)


Gene name yafQ Uniprot ID A0A510WIJ9
Locus tag C1191_RS07070 Protein ID WP_016363448.1
Coordinates 1306469..1306771 (+) Length 101 a.a.

Antitoxin (Protein)


Gene name dinJ Uniprot ID K6SLT0
Locus tag C1191_RS07065 Protein ID WP_003570051.1
Coordinates 1306207..1306476 (+) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C1191_RS07035 1301212..1302099 - 888 WP_003570041.1 ABC transporter ATP-binding protein -
C1191_RS07040 1302296..1303522 - 1227 WP_003570043.1 hypothetical protein -
C1191_RS07045 1303720..1304124 + 405 WP_003570045.1 MerR family transcriptional regulator -
C1191_RS07050 1304117..1304443 + 327 WP_003584272.1 YrdB family protein -
C1191_RS07055 1304506..1305135 + 630 WP_101512010.1 DUF2399 domain-containing protein -
C1191_RS07060 1305180..1305833 + 654 WP_003570049.1 GNAT family N-acetyltransferase -
C1191_RS07065 1306207..1306476 + 270 WP_003570051.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
C1191_RS07070 1306469..1306771 + 303 WP_016363448.1 type II toxin-antitoxin system YafQ family toxin Toxin
C1191_RS15990 1307110..1307253 + 144 WP_162259784.1 hypothetical protein -
C1191_RS07075 1307371..1308063 + 693 WP_003570055.1 hypothetical protein -
C1191_RS07080 1308299..1310476 + 2178 WP_003570057.1 RNA-binding transcriptional accessory protein -
C1191_RS07085 1310901..1311458 - 558 WP_003584278.1 helix-turn-helix domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(3-97)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(10-70)


Sequences

Toxin        


Download         Length: 101 a.a.        Molecular weight: 11510.33 Da        Isoelectric Point: 9.8881

>T93286 WP_016363448.1 NZ_CP026097:1306469-1306771 [Lacticaseibacillus paracasei]
MYSLVPTPTFKRDLKRLSKKHWPMDELKTAVNLLAAGTNAELLSKKYADHALSSSSEWKGYRELYVDGPRGDWLLIYKIE
QQDLILTLVRTGSHHNLLVK

Download         Length: 303 bp

>T93286 NZ_CP026097:1306469-1306771 [Lacticaseibacillus paracasei]
ATGTATAGTCTGGTTCCGACGCCTACATTTAAGCGCGATCTAAAACGACTCTCCAAGAAGCATTGGCCGATGGACGAACT
AAAGACGGCTGTTAATCTCCTAGCCGCTGGTACAAATGCTGAACTATTAAGCAAAAAGTATGCAGATCATGCCTTGTCCT
CAAGCAGCGAGTGGAAAGGATATCGTGAACTATATGTTGACGGCCCTCGTGGCGACTGGTTGCTAATCTATAAAATTGAG
CAGCAAGATCTTATTTTAACCCTAGTTAGAACCGGATCTCATCATAACCTTCTGGTTAAATAG

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 9982.68 Da        Isoelectric Point: 7.2026

>AT93286 WP_003570051.1 NZ_CP026097:1306207-1306476 [Lacticaseibacillus paracasei]
MAATKKETRLNIRVDPELKSAAQIVANDMGIDLTAAVTMFMTKMVKDHALPFTPTSLPVETLQALKEAKHPELLKKYSTP
DDMWRDLNV

Download         Length: 270 bp

>AT93286 NZ_CP026097:1306207-1306476 [Lacticaseibacillus paracasei]
ATGGCAGCCACAAAGAAGGAAACTCGCTTGAATATTCGTGTTGATCCTGAATTAAAAAGTGCTGCTCAAATCGTAGCAAA
TGATATGGGCATCGACTTGACCGCAGCTGTTACGATGTTCATGACGAAAATGGTGAAAGATCACGCCCTCCCGTTTACCC
CAACAAGTCTACCAGTTGAAACCTTACAGGCGCTGAAAGAAGCAAAGCACCCAGAGCTGCTCAAAAAATACAGCACGCCT
GATGACATGTGGAGAGACTTGAATGTATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A510WIJ9

Antitoxin

Source ID Structure
AlphaFold DB A0A0E2BRK6

References