Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-RelB
Location 2060421..2060934 Replicon chromosome
Accession NZ_CP026082
Organism Streptococcus agalactiae strain YZ1605

Toxin (Protein)


Gene name yoeB Uniprot ID Q8DX49
Locus tag C2E46_RS10285 Protein ID WP_000481712.1
Coordinates 2060421..2060675 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID Q8DX48
Locus tag C2E46_RS10290 Protein ID WP_000387490.1
Coordinates 2060668..2060934 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C2E46_RS10265 2056185..2058686 - 2502 WP_000239414.1 ATP-binding protein -
C2E46_RS10270 2058707..2059117 - 411 WP_000390747.1 conjugal transfer protein -
C2E46_RS10275 2059128..2059394 - 267 WP_001055037.1 hypothetical protein -
C2E46_RS10280 2059415..2060368 - 954 WP_000565540.1 conjugal transfer protein -
C2E46_RS10285 2060421..2060675 - 255 WP_000481712.1 Txe/YoeB family addiction module toxin Toxin
C2E46_RS10290 2060668..2060934 - 267 WP_000387490.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
C2E46_RS10295 2061079..2061552 - 474 WP_000560386.1 hypothetical protein -
C2E46_RS10300 2061560..2062042 - 483 WP_000383283.1 antirestriction protein ArdA -
C2E46_RS10305 2062095..2062367 - 273 WP_000017154.1 hypothetical protein -
C2E46_RS10310 2062631..2063071 - 441 WP_000010054.1 hypothetical protein -
C2E46_RS10315 2063074..2064423 - 1350 WP_000491712.1 AAA family ATPase -
C2E46_RS10320 2064620..2064919 - 300 WP_000737133.1 helix-turn-helix domain-containing protein -
C2E46_RS10325 2064903..2065280 - 378 WP_000287186.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - cfa/cfb 2048742..2090618 41876


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(4-83)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10445.87 Da        Isoelectric Point: 6.7282

>T93245 WP_000481712.1 NZ_CP026082:c2060675-2060421 [Streptococcus agalactiae]
MFNFTEEAWKDYVSWQQEDKKILKRINRLIEDIKRDPFEGIGKPEPLKYHYSGAWSRRITEEHRLIYMIEDGEIYFLSFR
DHYK

Download         Length: 255 bp

>T93245 NZ_CP026082:c2060675-2060421 [Streptococcus agalactiae]
ATGTTTAATTTTACTGAAGAAGCATGGAAAGATTATGTTTCTTGGCAACAGGAAGATAAAAAAATCTTGAAACGAATTAA
TCGTTTGATAGAAGATATTAAAAGAGACCCATTTGAAGGCATTGGAAAACCAGAACCTTTAAAATACCATTATTCAGGGG
CTTGGTCTCGAAGAATTACAGAAGAACATAGGTTGATTTATATGATAGAAGATGGAGAAATCTATTTTTTATCTTTTAGA
GATCATTATAAGTAG

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10316.70 Da        Isoelectric Point: 4.6742

>AT93245 WP_000387490.1 NZ_CP026082:c2060934-2060668 [Streptococcus agalactiae]
MEAIVYSHFRNNLKDYMKKVNDEFEPLIVVNKNPDENIVVLSQDSWESLQETIRLMENDYLSHKVINGISQVKEKQVTKH
GLIEVEDV

Download         Length: 267 bp

>AT93245 NZ_CP026082:c2060934-2060668 [Streptococcus agalactiae]
ATGGAGGCTATTGTTTATTCACATTTTAGAAATAATTTAAAAGATTATATGAAGAAGGTCAATGATGAATTTGAGCCTTT
GATTGTAGTTAATAAAAATCCTGATGAAAATATAGTGGTTTTATCTCAAGATAGCTGGGAAAGTTTACAAGAAACGATTC
GTTTGATGGAAAATGATTATCTATCACATAAGGTTATTAATGGTATATCACAAGTTAAAGAGAAGCAAGTCACTAAACAT
GGTTTAATTGAGGTAGAAGATGTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829IC12

Antitoxin

Source ID Structure
AlphaFold DB A0A829I9V6

References