Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2348032..2348549 Replicon chromosome
Accession NZ_CP026080
Organism Staphylococcus aureus strain FDAARGOS_12

Toxin (Protein)


Gene name yoeB Uniprot ID T1YC79
Locus tag RK70_RS11995 Protein ID WP_000113262.1
Coordinates 2348283..2348549 (+) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID T1YB60
Locus tag RK70_RS11990 Protein ID WP_000584499.1
Coordinates 2348032..2348283 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
RK70_RS11960 2343730..2344449 + 720 WP_000479576.1 amino acid ABC transporter permease -
RK70_RS11965 2344446..2345177 + 732 WP_000615461.1 amino acid ABC transporter ATP-binding protein -
RK70_RS11970 2345274..2346524 - 1251 WP_001012222.1 FemA/FemB family glycyltransferase FmhA -
RK70_RS11975 2346779..2347141 + 363 WP_000819843.1 DUF4467 domain-containing protein -
RK70_RS11980 2347160..2347759 + 600 WP_000162813.1 DsbA family protein -
RK70_RS11985 2347766..2347867 + 102 WP_001791744.1 hypothetical protein -
RK70_RS11990 2348032..2348283 + 252 WP_000584499.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
RK70_RS11995 2348283..2348549 + 267 WP_000113262.1 Txe/YoeB family addiction module toxin Toxin
RK70_RS12000 2348584..2348655 + 72 Protein_2213 hypothetical protein -
RK70_RS12005 2348844..2350394 + 1551 WP_000727762.1 zinc ABC transporter substrate-binding lipoprotein AdcA -
RK70_RS12010 2350580..2351047 + 468 WP_000153344.1 SRPBCC domain-containing protein -
RK70_RS12015 2351131..2351313 + 183 WP_000230294.1 hypothetical protein -
RK70_RS12020 2351530..2352354 + 825 WP_000572040.1 formate/nitrite transporter family protein -
RK70_RS12025 2352587..2353123 + 537 WP_000169315.1 GNAT family N-acetyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10437.95 Da        Isoelectric Point: 9.9143

>T93237 WP_000113262.1 NZ_CP026080:2348283-2348549 [Staphylococcus aureus]
MARLNITFSPQAFEDYKYFQQNDKKMVKKINELLKSIDRNGALEGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY

Download         Length: 267 bp

>T93237 NZ_CP026080:2348283-2348549 [Staphylococcus aureus]
ATGGCTAGGTTAAATATTACGTTTTCGCCTCAAGCCTTTGAAGATTATAAGTATTTTCAGCAGAACGATAAAAAAATGGT
GAAGAAGATTAATGAGTTACTTAAAAGTATTGACAGAAATGGTGCATTGGAAGGTATAGGTAAGCCTGAAAAGTTAAAAT
CGAATCTGACTGGGTATTATAGTAGACGTATCAATCACGAACATAGATTGGTTTATACAGTAGATGACAATCATATAAAA
ATAGCATCATGTAAATACCATTATTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9433.60 Da        Isoelectric Point: 4.3407

>AT93237 WP_000584499.1 NZ_CP026080:2348032-2348283 [Staphylococcus aureus]
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV

Download         Length: 252 bp

>AT93237 NZ_CP026080:2348032-2348283 [Staphylococcus aureus]
ATGATTATTAAAAATTATTCATACGCTCGACAGAATTTAAAGGCACTTATGACAAAAGTAAATGATGATAGTGATATGGT
AACTGTAACATCTACTGATGATAAAAACGTAGTAATCATGTCAGAATCAGATTATAACTCCATGATGGAAACACTTTACC
TCCAACAGAACCCAAATAATGCTGAACACTTAGCTCAATCAATTGCAGATCTAGAACGTGGGAAAACTATAACGAAAGAT
ATAGATGTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6L8G
PDB 6L8F
PDB 7CUA
PDB 6L8E

Antitoxin

Source ID Structure
PDB 6L8G
PDB 6L8F
PDB 7BWF
PDB 6L8E
AlphaFold DB T1YB60

References