Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) SprA2-SprA2AS/-
Location 2323013..2323197 Replicon chromosome
Accession NZ_CP026080
Organism Staphylococcus aureus strain FDAARGOS_12

Toxin (Protein)


Gene name SprA2 Uniprot ID Q2FVI9
Locus tag RK70_RS11835 Protein ID WP_000482650.1
Coordinates 2323013..2323120 (+) Length 36 a.a.

Antitoxin (RNA)


Gene name SprA2AS
Locus tag -
Coordinates 2323137..2323197 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
RK70_RS11810 2318375..2318848 + 474 WP_000456489.1 GyrI-like domain-containing protein -
RK70_RS11815 2318971..2320182 - 1212 WP_001192075.1 multidrug effflux MFS transporter -
RK70_RS11820 2320364..2321023 - 660 WP_000831298.1 membrane protein -
RK70_RS11825 2321083..2322225 - 1143 WP_001176863.1 glycerate kinase -
RK70_RS11830 2322493..2322879 + 387 WP_000779358.1 flippase GtxA -
RK70_RS11835 2323013..2323120 + 108 WP_000482650.1 type I toxin-antitoxin system Fst family toxin Toxin
- 2323137..2323197 - 61 - - Antitoxin
RK70_RS11845 2323748..2325511 + 1764 WP_001064838.1 ABC transporter ATP-binding protein/permease -
RK70_RS11850 2325536..2327269 + 1734 WP_000486494.1 ABC transporter ATP-binding protein/permease -
RK70_RS11860 2327500..2327667 + 168 WP_001790576.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.



Sequences

Toxin        


Download         Length: 36 a.a.        Molecular weight: 4011.78 Da        Isoelectric Point: 11.0582

>T93235 WP_000482650.1 NZ_CP026080:2323013-2323120 [Staphylococcus aureus]
MFNLLINIMTSAISGCLVAFFAHWLRTRNNKKGDK

Download         Length: 108 bp

>T93235 NZ_CP026080:2323013-2323120 [Staphylococcus aureus]
ATGTTCAATTTATTAATTAACATCATGACTTCAGCTATAAGCGGCTGTCTTGTTGCGTTTTTTGCACATTGGTTACGAAC
GCGCAACAATAAAAAAGGTGACAAATAA

Antitoxin


Download         Length: 61 bp

>AT93235 NZ_CP026080:c2323197-2323137 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2C9TTS8

Antitoxin

Download structure file

References