Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) SprA2-SprA2AS/-
Location 1196731..1196915 Replicon chromosome
Accession NZ_CP026079
Organism Staphylococcus aureus strain FDAARGOS_9

Toxin (Protein)


Gene name SprA2 Uniprot ID A0A2U0ISP5
Locus tag RK67_RS05960 Protein ID WP_000482652.1
Coordinates 1196731..1196838 (+) Length 36 a.a.

Antitoxin (RNA)


Gene name SprA2AS
Locus tag -
Coordinates 1196855..1196915 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
RK67_RS05935 1192093..1192566 + 474 WP_000456486.1 GyrI-like domain-containing protein -
RK67_RS05940 1192689..1193900 - 1212 WP_001192075.1 multidrug effflux MFS transporter -
RK67_RS05945 1194082..1194741 - 660 WP_000831298.1 membrane protein -
RK67_RS05950 1194801..1195943 - 1143 WP_001176863.1 glycerate kinase -
RK67_RS05955 1196211..1196597 + 387 WP_000779360.1 flippase GtxA -
RK67_RS05960 1196731..1196838 + 108 WP_000482652.1 type I toxin-antitoxin system Fst family toxin Toxin
- 1196855..1196915 - 61 - - Antitoxin
RK67_RS05970 1197541..1199304 + 1764 WP_001064825.1 ABC transporter ATP-binding protein/permease -
RK67_RS05975 1199329..1201062 + 1734 WP_000486487.1 ABC transporter ATP-binding protein/permease -
RK67_RS05985 1201293..1201460 + 168 Protein_1115 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.



Sequences

Toxin        


Download         Length: 36 a.a.        Molecular weight: 4011.78 Da        Isoelectric Point: 11.0582

>T93214 WP_000482652.1 NZ_CP026079:1196731-1196838 [Staphylococcus aureus]
MFNLLINIMTSALSGCLVAFFAHWLRTRNNKKGDK

Download         Length: 108 bp

>T93214 NZ_CP026079:1196731-1196838 [Staphylococcus aureus]
ATGTTCAATTTATTAATTAACATCATGACTTCAGCTTTAAGCGGCTGTCTTGTTGCGTTTTTTGCACATTGGTTACGAAC
GCGCAACAATAAAAAAGGTGACAAATAA

Antitoxin


Download         Length: 61 bp

>AT93214 NZ_CP026079:c1196915-1196855 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2U0ISP5

Antitoxin

Download structure file

References