Detailed information of TA system TA093186

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-SprF3/-
• Location: 118648..118947
• Replicon: chromosome
• Accession: NZ_CP026076
• Organism: Staphylococcus aureus strain FDAARGOS_4

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: Q2FWU9
• Locus tag: RK63_RS00805
• Protein ID: WP_011447039.1
• Coordinates: 118771..118947 (-)
• Length: 59 a.a.

Antitoxin (RNA)

Gene name	SprF3
Locus tag	-
Coordinates	118648..118703 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
RK63_RS00760	113978..114238	+	261	WP_001791826.1	hypothetical protein	-
RK63_RS00765	114291..114641	-	351	WP_000702263.1	complement inhibitor SCIN-A	-
RK63_RS00770	115327..115776	+	450	WP_000727649.1	chemotaxis-inhibiting protein CHIPS	-
RK63_RS00775	115871..116206	-	336	Protein_113	SH3 domain-containing protein	-
RK63_RS00785	116856..117347	-	492	WP_000919350.1	staphylokinase	-
RK63_RS00790	117538..118293	-	756	WP_000861038.1	CHAP domain-containing protein	-
RK63_RS00795	118305..118559	-	255	WP_000611512.1	phage holin	-
RK63_RS00800	118611..118718	+	108	WP_001791821.1	hypothetical protein	-
-	118640..118779	+	140	NuclAT_0	-	-
-	118640..118779	+	140	NuclAT_0	-	-
-	118640..118779	+	140	NuclAT_0	-	-
-	118640..118779	+	140	NuclAT_0	-	-
-	118648..118703	+	56	-	-	Antitoxin
RK63_RS00805	118771..118947	-	177	WP_011447039.1	putative holin-like toxin	Toxin
RK63_RS00810	119097..119393	-	297	WP_000539688.1	DUF2951 domain-containing protein	-
RK63_RS00815	119451..119738	-	288	WP_001040261.1	hypothetical protein	-
RK63_RS00820	119785..119937	-	153	WP_001153681.1	hypothetical protein	-
RK63_RS00825	119927..123712	-	3786	WP_000582165.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	scn / chp / sak / hlb / groEL	114291..173259	58968

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (30-58)

Sequences

Toxin

Protein

• Length: 59 a.a.
• Molecular weight: 6849.45 Da
• Isoelectric Point: 10.6777

>T93186 WP_011447039.1 NZ_CP026076:c118947-118771 [Staphylococcus aureus]
MDRWWLSEYKEVVPMVALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSNKK

Nucleotide

• Length: 177 bp

>T93186 NZ_CP026076:c118947-118771 [Staphylococcus aureus]
TTGGATAGATGGTGGCTATCTGAGTATAAGGAGGTGGTGCCTATGGTGGCATTACTGAAATCTTTAGAAAGGAGACGCCT
AATGATTACAATTAGTACCATGTTGCAGTTTGGTTTATTCCTTATTGCATTGATAGGTCTAGTAATCAAGCTTATTGAAT
TAAGCAATAAAAAATAA

Antitoxin

Nucleotide

• Length: 56 bp

>AT93186 NZ_CP026076:118648-118703 [Staphylococcus aureus]
AAAAAGGGCAACATGCGCAAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTG

Structures

Toxin

• PDB: 7NS1

Antitoxin