Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) SprA2-SprA2AS/-
Location 1038992..1039176 Replicon chromosome
Accession NZ_CP026074
Organism Staphylococcus aureus strain FDAARGOS_47

Toxin (Protein)


Gene name SprA2 Uniprot ID A0A2U0ISP5
Locus tag RL05_RS06045 Protein ID WP_000482652.1
Coordinates 1039069..1039176 (-) Length 36 a.a.

Antitoxin (RNA)


Gene name SprA2AS
Locus tag -
Coordinates 1038992..1039052 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
RL05_RS06020 1034447..1034614 - 168 Protein_1108 hypothetical protein -
RL05_RS06030 1034845..1036578 - 1734 WP_000486487.1 ABC transporter ATP-binding protein/permease -
RL05_RS06035 1036603..1038366 - 1764 WP_001064825.1 ABC transporter ATP-binding protein/permease -
- 1038992..1039052 + 61 - - Antitoxin
RL05_RS06045 1039069..1039176 - 108 WP_000482652.1 type I toxin-antitoxin system Fst family toxin Toxin
RL05_RS06050 1039310..1039696 - 387 WP_000779360.1 flippase GtxA -
RL05_RS06055 1039964..1041106 + 1143 WP_001176863.1 glycerate kinase -
RL05_RS06060 1041166..1041825 + 660 WP_000831298.1 membrane protein -
RL05_RS06065 1042007..1043218 + 1212 WP_001192075.1 multidrug effflux MFS transporter -
RL05_RS06070 1043341..1043814 - 474 WP_000456486.1 GyrI-like domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(8-106)


Sequences

Toxin        


Download         Length: 36 a.a.        Molecular weight: 4011.78 Da        Isoelectric Point: 11.0582

>T93180 WP_000482652.1 NZ_CP026074:c1039176-1039069 [Staphylococcus aureus]
MFNLLINIMTSALSGCLVAFFAHWLRTRNNKKGDK

Download         Length: 108 bp

>T93180 NZ_CP026074:c1039176-1039069 [Staphylococcus aureus]
ATGTTCAATTTATTAATTAACATCATGACTTCAGCTTTAAGCGGCTGTCTTGTTGCGTTTTTTGCACATTGGTTACGAAC
GCGCAACAATAAAAAAGGTGACAAATAA

Antitoxin


Download         Length: 61 bp

>AT93180 NZ_CP026074:1038992-1039052 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2U0ISP5

Antitoxin

Download structure file

References