Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 1013688..1014205 Replicon chromosome
Accession NZ_CP026074
Organism Staphylococcus aureus strain FDAARGOS_47

Toxin (Protein)


Gene name yoeB Uniprot ID A0A3A3ATA4
Locus tag RL05_RS05885 Protein ID WP_000113265.1
Coordinates 1013688..1013954 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID T1YB60
Locus tag RL05_RS05890 Protein ID WP_000584499.1
Coordinates 1013954..1014205 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
RL05_RS05855 1009116..1009652 - 537 WP_000169317.1 GNAT family N-acetyltransferase -
RL05_RS05860 1009886..1010710 - 825 WP_000572038.1 formate/nitrite transporter family protein -
RL05_RS05865 1010927..1011109 - 183 WP_000230292.1 hypothetical protein -
RL05_RS05870 1011193..1011660 - 468 WP_000153347.1 SRPBCC domain-containing protein -
RL05_RS05875 1011846..1013393 - 1548 WP_000727772.1 zinc ABC transporter substrate-binding lipoprotein AdcA -
RL05_RS05880 1013582..1013653 - 72 Protein_1083 hypothetical protein -
RL05_RS05885 1013688..1013954 - 267 WP_000113265.1 Txe/YoeB family addiction module toxin Toxin
RL05_RS05890 1013954..1014205 - 252 WP_000584499.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
RL05_RS05895 1014370..1014471 - 102 Protein_1086 hypothetical protein -
RL05_RS05900 1014478..1015077 - 600 WP_000162810.1 DsbA family protein -
RL05_RS05905 1015096..1015458 - 363 WP_000819843.1 DUF4467 domain-containing protein -
RL05_RS05910 1015713..1016963 + 1251 WP_001012225.1 FemA/FemB family glycyltransferase FmhA -
RL05_RS05915 1017060..1017791 - 732 WP_000615461.1 amino acid ABC transporter ATP-binding protein -
RL05_RS05920 1017788..1018507 - 720 WP_000479576.1 amino acid ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-81)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10436.96 Da        Isoelectric Point: 10.0573

>T93179 WP_000113265.1 NZ_CP026074:c1013954-1013688 [Staphylococcus aureus]
MARLNITFSPQAFEDYKYFQQNNKKMVKKINELLKSIDRNGALEGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY

Download         Length: 267 bp

>T93179 NZ_CP026074:c1013954-1013688 [Staphylococcus aureus]
ATGGCTAGGTTAAATATTACGTTTTCGCCTCAAGCCTTTGAAGATTATAAGTATTTTCAGCAGAACAATAAAAAAATGGT
GAAGAAGATTAATGAGTTACTTAAAAGTATTGACAGAAATGGTGCATTGGAAGGTATAGGTAAGCCTGAAAAGTTAAAAT
CGAATCTGACTGGGTATTATAGTAGACGTATCAATCACGAACATAGATTGGTTTATACAGTAGATGACAATCATATAAAA
ATAGCATCATGTAAATACCATTATTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9433.60 Da        Isoelectric Point: 4.3407

>AT93179 WP_000584499.1 NZ_CP026074:c1014205-1013954 [Staphylococcus aureus]
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV

Download         Length: 252 bp

>AT93179 NZ_CP026074:c1014205-1013954 [Staphylococcus aureus]
ATGATTATTAAAAATTATTCATACGCTCGACAGAATTTAAAGGCACTTATGACAAAAGTAAATGATGATAGTGATATGGT
AACTGTAACATCTACTGATGATAAAAACGTAGTAATCATGTCAGAATCAGATTATAACTCCATGATGGAAACACTTTACC
TCCAACAGAACCCAAATAATGCTGAACACTTAGCTCAATCAATTGCAGATCTAGAACGTGGGAAAACTATAACGAAAGAT
ATAGATGTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7BWF

Antitoxin

Source ID Structure
PDB 6L8G
PDB 6L8F
PDB 7BWF
PDB 6L8E
AlphaFold DB T1YB60

References