Detailed information of TA system TA093176

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): TMCS/-
• Location: 806067..806646
• Replicon: chromosome
• Accession: NZ_CP026074
• Organism: Staphylococcus aureus strain FDAARGOS_47

Toxin (Protein)

• Gene name: MW1434
• Uniprot ID: A0A4P7P609
• Locus tag: RL05_RS04685
• Protein ID: WP_001025401.1
• Coordinates: 806401..806646 (-)
• Length: 82 a.a.

Antitoxin (RNA)

Gene name	MW1433
Locus tag	-
Coordinates	806067..806432 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
RL05_RS04645	802810..803367	-	558	WP_000645042.1	DUF2815 family protein	-
RL05_RS04650	803393..804559	-	1167	WP_031879932.1	DUF2800 domain-containing protein	-
RL05_RS04655	804556..804918	-	363	WP_047216578.1	hypothetical protein	-
RL05_RS04660	804933..805256	-	324	WP_000174994.1	hypothetical protein	-
RL05_RS04665	805335..805496	-	162	WP_001285963.1	DUF1270 family protein	-
RL05_RS04670	805509..805772	-	264	WP_001124190.1	helix-turn-helix domain-containing protein	-
RL05_RS04675	805797..806012	-	216	WP_031808254.1	hypothetical protein	-
RL05_RS04680	806067..806432	+	366	WP_001128433.1	hypothetical protein	Antitoxin
RL05_RS04685	806401..806646	-	246	WP_001025401.1	DUF2829 domain-containing protein	Toxin
RL05_RS04690	806666..806890	-	225	WP_000333485.1	DUF739 family protein	-
RL05_RS04695	807052..807432	+	381	WP_001089477.1	helix-turn-helix domain-containing protein	-
RL05_RS04700	807454..807912	+	459	WP_047216581.1	toxin	-
RL05_RS04705	807929..808363	+	435	WP_047216584.1	hypothetical protein	-
RL05_RS04710	808392..808787	+	396	WP_000449655.1	hypothetical protein	-
RL05_RS04715	808877..809023	+	147	WP_001795334.1	hypothetical protein	-
RL05_RS04720	809020..809634	-	615	WP_000191463.1	hypothetical protein	-
RL05_RS04725	809760..810965	+	1206	WP_000264751.1	site-specific integrase	-
RL05_RS04730	811037..811639	-	603	Protein_864	family 1 glycosylhydrolase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	766086..820269	54183

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Protein of unknown function DUF2829 (2-69)

Sequences

Toxin

Protein

• Length: 82 a.a.
• Molecular weight: 9468.72 Da
• Isoelectric Point: 5.7783

>T93176 WP_001025401.1 NZ_CP026074:c806646-806401 [Staphylococcus aureus]
MNIQEATKIATKNLVSMTRKDWKESHRTKILPTNDSFLQCIISNSDGTNLIRYWQPSADDLMANDWEVINPTRDQELLKQ
F

Nucleotide

• Length: 246 bp

>T93176 NZ_CP026074:c806646-806401 [Staphylococcus aureus]
ATGAACATTCAAGAAGCAACTAAGATAGCTACAAAAAATCTTGTCTCTATGACACGGAAAGATTGGAAAGAAAGTCATCG
AACTAAGATATTACCAACAAATGATAGTTTTTTACAATGCATCATTTCAAATAGCGATGGGACAAACCTTATCAGATATT
GGCAACCTTCAGCCGATGACCTCATGGCAAATGATTGGGAAGTTATAAACCCAACTAGAGACCAGGAATTATTGAAGCAA
TTTTAG

Antitoxin

Nucleotide

• Length: 366 bp

>AT93176 NZ_CP026074:806067-806432 [Staphylococcus aureus]
ATGCCCTTGATATCTGATGAATTTGATACACTTACTAAAGACCAACAATATATCTTGTCCGTACTCTACAAAGATTATTT
AGAATGTGTAAAGCTAGGTTCGGTTAAATTAACCTGCAATAATTTTGGAAGTGCTAAAGATATACATACAAAGTATTTTC
AAAAACTACATTTCGAAGATGTAAAATACGATTTAAATAAACTTAAAAACTCTGGGTTCCTAAACGGCGTGTATGCTAGT
AACACTATTTATCATGTAACAATTTCAGACAAGACTGTTGTTTACTTTGAAAATGAGTTTAAAAACAATTTAAAAAGTAT
CATTGATAGCATTTCTAAAATTGCTTCAATAATTCCTGGTCTCTAG

Structures

Toxin

• AlphaFold DB: A0A4P7P609

Antitoxin