Detailed information of TA system TA093169

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-MW1433/-
• Location: 538026..538333
• Replicon: chromosome
• Accession: NZ_CP026074
• Organism: Staphylococcus aureus strain FDAARGOS_47

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: A0A4U0AGH1
• Locus tag: RL05_RS03175
• Protein ID: WP_072482930.1
• Coordinates: 538157..538333 (-)
• Length: 59 a.a.

Antitoxin (RNA)

Gene name	MW1433
Locus tag	-
Coordinates	538026..538165 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
RL05_RS03125	533367..533627	+	261	WP_001791826.1	hypothetical protein	-
RL05_RS03130	533680..534030	-	351	WP_000702262.1	complement inhibitor SCIN-A	-
RL05_RS03135	534713..535162	+	450	WP_000727645.1	chemotaxis-inhibiting protein CHIPS	-
RL05_RS03140	535257..535591	-	335	Protein_574	SH3 domain-containing protein	-
RL05_RS03155	536242..536733	-	492	WP_000920042.1	staphylokinase	-
RL05_RS03160	536924..537679	-	756	WP_000861040.1	CHAP domain-containing protein	-
RL05_RS03165	537691..537945	-	255	WP_000611512.1	phage holin	-
RL05_RS03170	537997..538104	+	108	Protein_578	hypothetical protein	-
-	538026..538165	+	140	NuclAT_0	-	Antitoxin
-	538026..538165	+	140	NuclAT_0	-	Antitoxin
-	538026..538165	+	140	NuclAT_0	-	Antitoxin
-	538026..538165	+	140	NuclAT_0	-	Antitoxin
RL05_RS03175	538157..538333	-	177	WP_072482930.1	putative holin-like toxin	Toxin
RL05_RS03180	538442..539215	-	774	WP_000750412.1	staphylococcal enterotoxin type A	-
RL05_RS03185	539588..539962	-	375	WP_000340977.1	hypothetical protein	-
RL05_RS03190	540018..540305	-	288	WP_001262621.1	hypothetical protein	-
RL05_RS03195	540351..540503	-	153	WP_001000058.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	scn / chp / sak / sea / hlb / groEL	533680..585080	51400

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (30-58)

Sequences

Toxin

Protein

• Length: 59 a.a.
• Molecular weight: 6883.46 Da
• Isoelectric Point: 10.6777

>T93169 WP_072482930.1 NZ_CP026074:c538333-538157 [Staphylococcus aureus]
MDRWWLSEYKEVVPMVALLKSLERRRLMITISTMLQFGLFLIAFIGLVIKLIELSNKK

Nucleotide

• Length: 177 bp

>T93169 NZ_CP026074:c538333-538157 [Staphylococcus aureus]
TTGGATAGATGGTGGCTATCTGAGTATAAGGAGGTGGTGCCTATGGTGGCATTACTGAAATCTTTAGAAAGGAGACGCCT
AATGATTACAATTAGTACCATGTTGCAGTTTGGTTTATTCCTTATTGCATTCATAGGTCTAGTAATCAAGCTTATTGAAT
TAAGCAATAAAAAATAA

Antitoxin

Nucleotide

• Length: 140 bp

>AT93169 NZ_CP026074:538026-538165 [Staphylococcus aureus]
ATATATATAAAAAGGGCAACATGCGCAAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTGGCTATTTTAGATTAAA
GATTAAATTAATAACCATTTAACCATCGAAACCAGCCAAAGTTAGCGATGGTTATTTTTT

Structures

Toxin

• AlphaFold DB: A0A4U0AGH1

Antitoxin