Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/-
Location 395678..396092 Replicon chromosome
Accession NZ_CP026074
Organism Staphylococcus aureus strain FDAARGOS_47

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag RL05_RS02165 Protein ID WP_047216542.1
Coordinates 395841..396092 (-) Length 84 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag RL05_RS15375 Protein ID WP_000028424.1
Coordinates 395678..395851 (-) Length 58 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
RL05_RS02110 390774..391982 - 1209 WP_001800917.1 PBSX family phage terminase large subunit -
RL05_RS15310 391975..392469 - 495 WP_000594082.1 terminase -
RL05_RS02120 392820..393221 - 402 WP_000286968.1 hypothetical protein -
RL05_RS02125 393222..393395 - 174 WP_047216536.1 transcriptional activator RinB -
RL05_RS02130 393392..393757 - 366 WP_000383754.1 hypothetical protein -
RL05_RS02135 393772..394008 - 237 WP_000608278.1 hypothetical protein -
RL05_RS02140 394001..394204 - 204 WP_001072794.1 hypothetical protein -
RL05_RS02145 394201..394407 - 207 WP_047216539.1 DUF1381 domain-containing protein -
RL05_RS02150 394404..394649 - 246 WP_001652276.1 hypothetical protein -
RL05_RS02155 394686..395219 - 534 WP_001061840.1 dUTPase -
RL05_RS15370 395237..395395 - 159 WP_000889681.1 hypothetical protein -
RL05_RS02160 395396..395677 - 282 WP_000454994.1 hypothetical protein -
RL05_RS15375 395678..395851 - 174 WP_000028424.1 hypothetical protein Antitoxin
RL05_RS02165 395841..396092 - 252 WP_047216542.1 DUF1024 family protein Toxin
RL05_RS02170 396107..396355 - 249 WP_047216544.1 phi PVL orf 51-like protein -
RL05_RS02175 396356..396715 - 360 WP_047216546.1 phage protein -
RL05_RS02180 396727..396984 - 258 WP_000772916.1 helix-turn-helix transcriptional regulator -
RL05_RS02185 396985..397170 - 186 WP_047216549.1 DUF3113 family protein -
RL05_RS02190 397175..397561 - 387 WP_000049806.1 DUF1064 domain-containing protein -
RL05_RS02195 397558..397983 - 426 WP_000451862.1 DNA N-6-adenine-methyltransferase -
RL05_RS02200 397993..398214 - 222 WP_001123690.1 DUF3269 family protein -
RL05_RS02205 398218..398433 - 216 WP_001024405.1 hypothetical protein -
RL05_RS02210 398430..399671 - 1242 WP_001106168.1 AAA family ATPase -
RL05_RS02215 399668..400024 - 357 WP_001132247.1 hypothetical protein -
RL05_RS02220 400024..400830 - 807 WP_000504973.1 phage replisome organizer N-terminal domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - lukD / hlgA / selk 334733..410704 75971


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Protein of unknown function DUF1024

(1-82)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 84 a.a.        Molecular weight: 9483.43 Da        Isoelectric Point: 3.9649

>T93167 WP_047216542.1 NZ_CP026074:c396092-395841 [Staphylococcus aureus]
MNKREQIEQSIISASAYNGNDTEGLLKEVEDVYKKAQAFDEILDGMTNAIQHSVKEDIYLDEAVGIMTSQVVYKYEEAQE
NEY

Download         Length: 252 bp

>T93167 NZ_CP026074:c396092-395841 [Staphylococcus aureus]
ATGAATAAACGCGAACAAATCGAACAATCAATTATCAGTGCTAGTGCCTATAACGGTAATGACACAGAGGGATTACTAAA
AGAGGTTGAAGACGTGTATAAGAAAGCACAAGCGTTTGATGAAATACTTGATGGAATGACAAATGCTATTCAACATTCAG
TTAAAGAAGATATTTATCTTGATGAAGCAGTAGGGATTATGACGAGTCAAGTGGTCTATAAATATGAGGAGGCGCAGGAA
AATGAGTATTAG

Antitoxin


Download         Length: 58 a.a.        Molecular weight: 6468.29 Da        Isoelectric Point: 4.2484

>AT93167 WP_000028424.1 NZ_CP026074:c395851-395678 [Staphylococcus aureus]
MSISVGDKVYNHETNESLEIVQLVGDIRDTHYKLSDDSVISIIDFITKPIYLIKGDE

Download         Length: 174 bp

>AT93167 NZ_CP026074:c395851-395678 [Staphylococcus aureus]
ATGAGTATTAGTGTAGGAGATAAAGTATATAACCATGAAACAAACGAAAGTCTAGAGATTGTGCAATTGGTCGGAGATAT
TAGAGATACACATTATAAACTGTCTGATGATTCAGTTATTAGCATTATAGATTTTATTACTAAACCAATTTATCTAATTA
AGGGGGACGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References