Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) sprA1-sprA1AS/-
Location 340328..340508 Replicon chromosome
Accession NZ_CP026074
Organism Staphylococcus aureus strain FDAARGOS_47

Toxin (Protein)


Gene name sprA1 Uniprot ID -
Locus tag RL05_RS15300 Protein ID WP_001801861.1
Coordinates 340328..340423 (+) Length 32 a.a.

Antitoxin (RNA)


Gene name sprA1AS
Locus tag -
Coordinates 340451..340508 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
RL05_RS01775 335491..336141 + 651 WP_001795210.1 excalibur calcium-binding domain-containing protein -
RL05_RS01780 336222..337217 + 996 WP_000070642.1 DUF4352 domain-containing protein -
RL05_RS01785 337292..337918 + 627 WP_000669024.1 hypothetical protein -
RL05_RS01790 337959..338300 + 342 WP_000627540.1 DUF3969 family protein -
RL05_RS01795 338401..338973 + 573 WP_000414216.1 hypothetical protein -
RL05_RS01800 339171..340183 - 1013 Protein_350 IS3 family transposase -
RL05_RS15300 340328..340423 + 96 WP_001801861.1 type I toxin-antitoxin system Fst family toxin PepA1 Toxin
- 340451..340508 - 58 - - Antitoxin
RL05_RS01805 340546..340647 + 102 WP_001792025.1 hypothetical protein -
RL05_RS01810 340625..340786 - 162 Protein_353 transposase -
RL05_RS01815 340777..341271 - 495 Protein_354 transposase -
RL05_RS01820 341723..342952 - 1230 WP_000072627.1 restriction endonuclease subunit S -
RL05_RS01825 342945..344501 - 1557 WP_000028669.1 type I restriction-modification system subunit M -
RL05_RS01830 344665..344799 - 135 WP_001791797.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - lukD / hlgA / selk 334733..410704 75971


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.



Sequences

Toxin        


Download         Length: 32 a.a.        Molecular weight: 3554.32 Da        Isoelectric Point: 10.4449

>T93165 WP_001801861.1 NZ_CP026074:340328-340423 [Staphylococcus aureus]
VMLIFVHIIAPVISGCAIAFFSYWLSRRNTK

Download         Length: 96 bp

>T93165 NZ_CP026074:340328-340423 [Staphylococcus aureus]
GTGATGCTTATTTTCGTTCACATCATAGCACCAGTCATCAGTGGCTGTGCCATTGCGTTTTTTTCTTATTGGCTAAGTAG
ACGCAATACAAAATAG

Antitoxin


Download         Length: 58 bp

>AT93165 NZ_CP026074:c340508-340451 [Staphylococcus aureus]
AACGAAAATAAGTATTTACTTATACACCAATCCCCTCACTATTTGCGGTAGTGAGGGG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Download structure file

References