Detailed information of TA system TA093161

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): TMCS/-
• Location: 14773..15352
• Replicon: chromosome
• Accession: NZ_CP026074
• Organism: Staphylococcus aureus strain FDAARGOS_47

Toxin (Protein)

• Gene name: MW1434
• Uniprot ID: A0A4P7P609
• Locus tag: RL05_RS00160
• Protein ID: WP_001025401.1
• Coordinates: 15107..15352 (-)
• Length: 82 a.a.

Antitoxin (RNA)

Gene name	MW1433
Locus tag	-
Coordinates	14773..15138 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
RL05_RS00120	11516..12073	-	558	WP_000645042.1	DUF2815 family protein	-
RL05_RS00125	12099..13265	-	1167	WP_047216521.1	DUF2800 domain-containing protein	-
RL05_RS00130	13262..13624	-	363	WP_000985976.1	hypothetical protein	-
RL05_RS00135	13639..13962	-	324	WP_000174994.1	hypothetical protein	-
RL05_RS00140	14041..14202	-	162	WP_001285963.1	DUF1270 family protein	-
RL05_RS00145	14215..14478	-	264	WP_001124190.1	helix-turn-helix domain-containing protein	-
RL05_RS00150	14503..14718	-	216	WP_001036302.1	hypothetical protein	-
RL05_RS00155	14773..15138	+	366	WP_001128433.1	hypothetical protein	Antitoxin
RL05_RS00160	15107..15352	-	246	WP_001025401.1	DUF2829 domain-containing protein	Toxin
RL05_RS00165	15368..15616	-	249	WP_000272861.1	helix-turn-helix domain-containing protein	-
RL05_RS00170	15780..16103	+	324	WP_001260486.1	helix-turn-helix domain-containing protein	-
RL05_RS00175	16116..16577	+	462	WP_000525014.1	hypothetical protein	-
RL05_RS00180	16594..17028	+	435	WP_047216523.1	hypothetical protein	-
RL05_RS00185	17057..17452	+	396	WP_000449655.1	hypothetical protein	-
RL05_RS00190	17542..17688	+	147	WP_001795334.1	hypothetical protein	-
RL05_RS00195	17685..18299	-	615	WP_000191463.1	hypothetical protein	-
RL05_RS00200	18425..19630	+	1206	WP_000264751.1	site-specific integrase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Protein of unknown function DUF2829 (2-69)

Sequences

Toxin

Protein

• Length: 82 a.a.
• Molecular weight: 9468.72 Da
• Isoelectric Point: 5.7783

>T93161 WP_001025401.1 NZ_CP026074:c15352-15107 [Staphylococcus aureus]
MNIQEATKIATKNLVSMTRKDWKESHRTKILPTNDSFLQCIISNSDGTNLIRYWQPSADDLMANDWEVINPTRDQELLKQ
F

Nucleotide

• Length: 246 bp

>T93161 NZ_CP026074:c15352-15107 [Staphylococcus aureus]
ATGAACATTCAAGAAGCAACTAAGATAGCTACAAAAAATCTTGTCTCTATGACACGGAAAGATTGGAAAGAAAGTCATCG
AACTAAGATATTACCAACAAATGATAGTTTTTTACAATGCATCATTTCAAATAGCGATGGGACAAACCTTATCAGATATT
GGCAACCTTCAGCCGATGACCTCATGGCAAATGATTGGGAAGTTATAAACCCAACTAGAGACCAGGAATTATTGAAGCAA
TTTTAG

Antitoxin

Nucleotide

• Length: 366 bp

>AT93161 NZ_CP026074:14773-15138 [Staphylococcus aureus]
ATGCCCTTGATATCTGATGAATTTGATACACTTACTAAAGACCAACAATATATCTTGTCCGTACTCTACAAAGATTATTT
AGAATGTGTAAAGTTAGGTTCGGTTAAATTAACCTGCAATAATTTTGGAAGTGCTAAAGATATACATACAAAGTATTTTC
AAAAACTACATTTCGAAGATGTAAAATACGATTTAAATAAACTTAAAAACTCTGGGTTCCTAAACGGCGTGTATGCTAGT
AACACTATTTATCATGTAACAATTTCAGACAAGACTGTTGTTTACTTTGAAAATGAGTTTAAAAACAATTTAAAAAGTAT
CATTGATAGCATTTCTAAAATTGCTTCAATAATTCCTGGTCTCTAG

Structures

Toxin

• AlphaFold DB: A0A4P7P609

Antitoxin