Detailed information of TA system TA093133

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-SprF1/-
• Location: 2431954..2432292
• Replicon: chromosome
• Accession: NZ_CP026072
• Organism: Staphylococcus aureus strain FDAARGOS_35

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: Q2FWU9
• Locus tag: RK93_RS12735
• Protein ID: WP_011447039.1
• Coordinates: 2431954..2432130 (+)
• Length: 59 a.a.

Antitoxin (RNA)

Gene name	SprF1
Locus tag	-
Coordinates	2432118..2432292 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
RK93_RS12715	2429784..2429936	+	153	WP_001000058.1	hypothetical protein	-
RK93_RS12720	2429982..2430269	+	288	WP_001262621.1	hypothetical protein	-
RK93_RS12725	2430325..2430699	+	375	WP_000340977.1	hypothetical protein	-
RK93_RS12730	2431072..2431845	+	774	WP_000750412.1	staphylococcal enterotoxin type A	-
RK93_RS12735	2431954..2432130	+	177	WP_011447039.1	putative holin-like toxin	Toxin
-	2432118..2432292	-	175	-	-	Antitoxin
RK93_RS12745	2432342..2432596	+	255	WP_000611508.1	phage holin	-
RK93_RS12750	2432608..2433363	+	756	WP_000861038.1	CHAP domain-containing protein	-
RK93_RS12755	2433554..2434045	+	492	WP_000920038.1	staphylokinase	-
RK93_RS12775	2434696..2435031	+	336	Protein_2396	SH3 domain-containing protein	-
RK93_RS12780	2435542..2435892	+	351	WP_000702263.1	complement inhibitor SCIN-A	-
RK93_RS12785	2435945..2436205	-	261	WP_001791826.1	hypothetical protein	-
RK93_RS12795	2436516..2436695	-	180	WP_000669791.1	hypothetical protein	-
RK93_RS12800	2437017..2437267	-	251	Protein_2400	sphingomyelin phosphodiesterase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	groEL / hlb / sea / sak / scn	2375184..2435892	60708

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (30-58)

Sequences

Toxin

Protein

• Length: 59 a.a.
• Molecular weight: 6849.45 Da
• Isoelectric Point: 10.6777

>T93133 WP_011447039.1 NZ_CP026072:2431954-2432130 [Staphylococcus aureus]
MDRWWLSEYKEVVPMVALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSNKK

Nucleotide

• Length: 177 bp

>T93133 NZ_CP026072:2431954-2432130 [Staphylococcus aureus]
TTGGATAGATGGTGGCTATCTGAGTATAAGGAGGTGGTGCCTATGGTGGCATTACTGAAATCTTTAGAAAGGAGACGCCT
AATGATTACAATTAGTACCATGTTGCAGTTTGGTTTATTCCTTATTGCATTGATAGGTCTAGTAATCAAGCTTATTGAAT
TAAGCAATAAAAAATAA

Antitoxin

Nucleotide

• Length: 175 bp

>AT93133 NZ_CP026072:c2432292-2432118 [Staphylococcus aureus]
ATTTGATATTTATATTATGGTGTGTTAATTTATATATAGAAAAAGGGCAACATGCGCAAACATGTTACCCTAGTGAGCCC
GTTAAAAAGACGGTGGCGATTTTAGATTAAAGATTAAATTAATAACCATTTAACCATCGAAACCAGCCAAAGTTAGCGAT
GGTTATTTTTTATTG

Structures

Toxin

• PDB: 7NS1

Antitoxin