Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 1988209..1988726 Replicon chromosome
Accession NZ_CP026072
Organism Staphylococcus aureus strain FDAARGOS_35

Toxin (Protein)


Gene name yoeB Uniprot ID T1YC79
Locus tag RK93_RS10220 Protein ID WP_000113262.1
Coordinates 1988460..1988726 (+) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID T1YB60
Locus tag RK93_RS10215 Protein ID WP_000584499.1
Coordinates 1988209..1988460 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
RK93_RS10185 1983907..1984626 + 720 WP_000479576.1 amino acid ABC transporter permease -
RK93_RS10190 1984623..1985354 + 732 WP_000615461.1 amino acid ABC transporter ATP-binding protein -
RK93_RS10195 1985451..1986701 - 1251 WP_001012222.1 FemA/FemB family glycyltransferase FmhA -
RK93_RS10200 1986956..1987318 + 363 WP_000819843.1 DUF4467 domain-containing protein -
RK93_RS10205 1987337..1987936 + 600 WP_000162813.1 DsbA family protein -
RK93_RS10210 1987943..1988044 + 102 WP_001791744.1 hypothetical protein -
RK93_RS10215 1988209..1988460 + 252 WP_000584499.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
RK93_RS10220 1988460..1988726 + 267 WP_000113262.1 Txe/YoeB family addiction module toxin Toxin
RK93_RS10225 1988761..1988832 + 72 Protein_1920 hypothetical protein -
RK93_RS10230 1989021..1990571 + 1551 WP_000727762.1 zinc ABC transporter substrate-binding lipoprotein AdcA -
RK93_RS10235 1990757..1991224 + 468 WP_000153344.1 SRPBCC domain-containing protein -
RK93_RS10240 1991308..1991490 + 183 WP_000230294.1 hypothetical protein -
RK93_RS10245 1991707..1992531 + 825 WP_000572040.1 formate/nitrite transporter family protein -
RK93_RS10250 1992764..1993300 + 537 WP_000169317.1 GNAT family N-acetyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10437.95 Da        Isoelectric Point: 9.9143

>T93126 WP_000113262.1 NZ_CP026072:1988460-1988726 [Staphylococcus aureus]
MARLNITFSPQAFEDYKYFQQNDKKMVKKINELLKSIDRNGALEGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY

Download         Length: 267 bp

>T93126 NZ_CP026072:1988460-1988726 [Staphylococcus aureus]
ATGGCTAGGTTAAATATTACGTTTTCGCCTCAAGCCTTTGAAGATTATAAGTATTTTCAGCAGAACGATAAAAAAATGGT
GAAGAAGATTAATGAGTTACTTAAAAGTATTGACAGAAATGGTGCATTGGAAGGTATAGGTAAGCCTGAAAAGTTAAAAT
CGAATCTGACTGGGTATTATAGTAGACGTATCAATCACGAACATAGATTGGTTTATACAGTAGATGACAATCATATAAAA
ATAGCATCATGTAAATACCATTATTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9433.60 Da        Isoelectric Point: 4.3407

>AT93126 WP_000584499.1 NZ_CP026072:1988209-1988460 [Staphylococcus aureus]
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV

Download         Length: 252 bp

>AT93126 NZ_CP026072:1988209-1988460 [Staphylococcus aureus]
ATGATTATTAAAAATTATTCATACGCTCGACAGAATTTAAAGGCACTTATGACAAAAGTAAATGATGATAGTGATATGGT
AACTGTAACATCTACTGATGATAAAAACGTAGTAATCATGTCAGAATCAGATTATAACTCCATGATGGAAACACTTTACC
TCCAACAGAACCCAAATAATGCTGAACACTTAGCTCAATCAATTGCAGATCTAGAACGTGGGAAAACTATAACGAAAGAT
ATAGATGTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6L8G
PDB 6L8F
PDB 7CUA
PDB 6L8E

Antitoxin

Source ID Structure
PDB 6L8G
PDB 6L8F
PDB 7BWF
PDB 6L8E
AlphaFold DB T1YB60

References