Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) SprA2-SprA2AS/-
Location 1963190..1963374 Replicon chromosome
Accession NZ_CP026072
Organism Staphylococcus aureus strain FDAARGOS_35

Toxin (Protein)


Gene name SprA2 Uniprot ID Q2FVI9
Locus tag RK93_RS10060 Protein ID WP_000482650.1
Coordinates 1963190..1963297 (+) Length 36 a.a.

Antitoxin (RNA)


Gene name SprA2AS
Locus tag -
Coordinates 1963314..1963374 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
RK93_RS10035 1958552..1959025 + 474 WP_000456489.1 GyrI-like domain-containing protein -
RK93_RS10040 1959148..1960359 - 1212 WP_001192075.1 multidrug effflux MFS transporter -
RK93_RS10045 1960541..1961200 - 660 WP_000831298.1 membrane protein -
RK93_RS10050 1961260..1962402 - 1143 WP_001176863.1 glycerate kinase -
RK93_RS10055 1962670..1963056 + 387 WP_000779358.1 flippase GtxA -
RK93_RS10060 1963190..1963297 + 108 WP_000482650.1 type I toxin-antitoxin system Fst family toxin Toxin
- 1963314..1963374 - 61 - - Antitoxin
RK93_RS10070 1963925..1965688 + 1764 WP_001064838.1 ABC transporter ATP-binding protein/permease -
RK93_RS10075 1965713..1967446 + 1734 WP_000486494.1 ABC transporter ATP-binding protein/permease -
RK93_RS10085 1967677..1967844 + 168 WP_001789936.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.



Sequences

Toxin        


Download         Length: 36 a.a.        Molecular weight: 4011.78 Da        Isoelectric Point: 11.0582

>T93124 WP_000482650.1 NZ_CP026072:1963190-1963297 [Staphylococcus aureus]
MFNLLINIMTSAISGCLVAFFAHWLRTRNNKKGDK

Download         Length: 108 bp

>T93124 NZ_CP026072:1963190-1963297 [Staphylococcus aureus]
ATGTTCAATTTATTAATTAACATCATGACTTCAGCTATAAGCGGCTGTCTTGTTGCGTTTTTTGCACATTGGTTACGAAC
GCGCAACAATAAAAAAGGTGACAAATAA

Antitoxin


Download         Length: 61 bp

>AT93124 NZ_CP026072:c1963374-1963314 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2C9TTS8

Antitoxin

Download structure file

References