Detailed information of TA system TA093109

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): TMCS/-
• Location: 1936196..1936775
• Replicon: chromosome
• Accession: NZ_CP026071
• Organism: Staphylococcus aureus strain FDAARGOS_30

Toxin (Protein)

• Gene name: MW1434
• Uniprot ID: A0A4P7P609
• Locus tag: RK88_RS10250
• Protein ID: WP_001025401.1
• Coordinates: 1936530..1936775 (-)
• Length: 82 a.a.

Antitoxin (RNA)

Gene name	MW1433
Locus tag	-
Coordinates	1936196..1936561 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
RK88_RS10195	1931393..1932211	-	819	WP_042905004.1	phage replisome organizer N-terminal domain-containing protein	-
RK88_RS10200	1932183..1932875	-	693	WP_042905006.1	phi PV83 orf 19-like protein	-
RK88_RS10205	1932888..1933442	-	555	WP_000704713.1	single-stranded DNA-binding protein	-
RK88_RS10210	1933472..1934251	-	780	WP_000137071.1	ATP-binding protein	-
RK88_RS10215	1934252..1934788	-	537	WP_000999048.1	host-nuclease inhibitor Gam family protein	-
RK88_RS10220	1934801..1935061	-	261	WP_042905007.1	DUF1108 family protein	-
RK88_RS10225	1935042..1935371	-	330	WP_000138304.1	hypothetical protein	-
RK88_RS10230	1935464..1935625	-	162	WP_001285954.1	DUF1270 domain-containing protein	-
RK88_RS10235	1935638..1935901	-	264	WP_001124160.1	helix-turn-helix domain-containing protein	-
RK88_RS10240	1935926..1936141	-	216	WP_001097552.1	hypothetical protein	-
RK88_RS10245	1936196..1936561	+	366	WP_001128433.1	hypothetical protein	Antitoxin
RK88_RS10250	1936530..1936775	-	246	WP_001025401.1	DUF2829 domain-containing protein	Toxin
RK88_RS10255	1936815..1937039	-	225	WP_000187184.1	hypothetical protein	-
RK88_RS10260	1937040..1937819	-	780	WP_042905009.1	phage antirepressor	-
RK88_RS10265	1937976..1938284	-	309	WP_001153965.1	hypothetical protein	-
RK88_RS10270	1938299..1938517	-	219	WP_001198673.1	helix-turn-helix domain-containing protein	-
RK88_RS10275	1938659..1939378	+	720	WP_000358220.1	XRE family transcriptional regulator	-
RK88_RS10280	1939577..1939759	+	183	WP_000705240.1	hypothetical protein	-
RK88_RS10285	1939905..1940528	-	624	WP_015994736.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	geh	1901552..1951083	49531

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Protein of unknown function DUF2829 (2-69)

Sequences

Toxin

Protein

• Length: 82 a.a.
• Molecular weight: 9468.72 Da
• Isoelectric Point: 5.7783

>T93109 WP_001025401.1 NZ_CP026071:c1936775-1936530 [Staphylococcus aureus]
MNIQEATKIATKNLVSMTRKDWKESHRTKILPTNDSFLQCIISNSDGTNLIRYWQPSADDLMANDWEVINPTRDQELLKQ
F

Nucleotide

• Length: 246 bp

>T93109 NZ_CP026071:c1936775-1936530 [Staphylococcus aureus]
ATGAACATTCAAGAAGCAACTAAGATAGCTACAAAAAATCTTGTCTCTATGACACGGAAAGATTGGAAAGAAAGTCATCG
AACTAAGATATTACCAACAAATGATAGTTTTTTACAATGCATCATTTCAAATAGCGATGGGACAAACCTTATCAGATATT
GGCAACCTTCAGCCGATGACCTCATGGCAAATGATTGGGAAGTTATAAACCCAACTAGAGACCAGGAATTATTGAAGCAA
TTTTAG

Antitoxin

Nucleotide

• Length: 366 bp

>AT93109 NZ_CP026071:1936196-1936561 [Staphylococcus aureus]
ATGCCCTTGATATCTGATGAATTTGATACACTTACTAAAGACCAACAATATATCTTGTCCGTACTCTACAAAGATTATTT
AGAATGTGTAAAGTTAGGTTCGGTTAAATTAACCTGCAATAATTTTGGAAGTGCTAAAGATATACATACAAAGTATTTTC
AAAAACTACATTTTGAAGATGTAAAATACGATTTAAATAAACTTAAAAACTCTGGGTTCCTAAACGGCGTGTATGCTAGT
AACACTATTTATCATGTAACAATTTCAGACAAGACTGTTGTTTACTTTGAAAATGAGTTTAAAAACAATTTAAAAAGTAT
CATTGATAGCATTTCTAAAATTGCTTCAATAATTCCTGGTCTCTAG

Structures

Toxin

• AlphaFold DB: A0A4P7P609

Antitoxin