Detailed information of TA system TA093107

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-SprF3/-
• Location: 1902662..1902961
• Replicon: chromosome
• Accession: NZ_CP026071
• Organism: Staphylococcus aureus strain FDAARGOS_30

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: A0A6B5C9Y4
• Locus tag: RK88_RS09975
• Protein ID: WP_072357969.1
• Coordinates: 1902785..1902961 (-)
• Length: 59 a.a.

Antitoxin (RNA)

Gene name	SprF3
Locus tag	-
Coordinates	1902662..1902719 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
RK88_RS09930	1898169..1898267	-	99	WP_001803958.1	hypothetical protein	-
RK88_RS09935	1898363..1899577	+	1215	WP_000286469.1	NADH-dependent flavin oxidoreductase	-
RK88_RS09940	1899635..1900462	+	828	WP_000136022.1	alpha/beta hydrolase	-
RK88_RS09960	1901552..1902307	-	756	WP_000861038.1	CHAP domain-containing protein	-
RK88_RS09965	1902319..1902573	-	255	WP_000611512.1	phage holin	-
RK88_RS09970	1902625..1902732	+	108	WP_031790389.1	hypothetical protein	-
-	1902654..1902793	+	140	NuclAT_1	-	-
-	1902654..1902793	+	140	NuclAT_1	-	-
-	1902654..1902793	+	140	NuclAT_1	-	-
-	1902654..1902793	+	140	NuclAT_1	-	-
-	1902662..1902719	+	58	-	-	Antitoxin
RK88_RS09975	1902785..1902961	-	177	WP_072357969.1	putative holin-like toxin	Toxin
RK88_RS09980	1903111..1903407	-	297	WP_000539688.1	DUF2951 domain-containing protein	-
RK88_RS09985	1903465..1903752	-	288	WP_001040261.1	hypothetical protein	-
RK88_RS09990	1903799..1903951	-	153	WP_001153681.1	hypothetical protein	-
RK88_RS09995	1903941..1907726	-	3786	WP_000582190.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	geh	1901552..1951083	49531

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (30-58)

Sequences

Toxin

Protein

• Length: 59 a.a.
• Molecular weight: 6863.47 Da
• Isoelectric Point: 10.6777

>T93107 WP_072357969.1 NZ_CP026071:c1902961-1902785 [Staphylococcus aureus]
MDRWWLSEYKEVVPMLALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSNKK

Nucleotide

• Length: 177 bp

>T93107 NZ_CP026071:c1902961-1902785 [Staphylococcus aureus]
TTGGATAGATGGTGGCTATCTGAGTATAAGGAGGTGGTGCCTATGTTGGCATTACTGAAATCTTTAGAAAGGAGACGCCT
AATGATTACAATTAGTACCATGTTGCAGTTTGGTTTATTCCTTATTGCATTGATAGGTCTAGTAATCAAGCTTATTGAAT
TAAGCAATAAAAAATAA

Antitoxin

Nucleotide

• Length: 58 bp

>AT93107 NZ_CP026071:1902662-1902719 [Staphylococcus aureus]
AAAAAGGGCAACATGCGCAAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTGAC

Structures

Toxin

• AlphaFold DB: A0A6B5C9Y4

Antitoxin