Detailed information of TA system TA093097

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-SprF1/-
• Location: 179654..179992
• Replicon: chromosome
• Accession: NZ_CP026071
• Organism: Staphylococcus aureus strain FDAARGOS_30

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: Q2FWU9
• Locus tag: RK88_RS01090
• Protein ID: WP_011447039.1
• Coordinates: 179654..179830 (+)
• Length: 59 a.a.

Antitoxin (RNA)

Gene name	SprF1
Locus tag	-
Coordinates	179818..179992 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
RK88_RS01065	177435..177587	+	153	WP_001153681.1	hypothetical protein	-
RK88_RS01070	177634..177921	+	288	WP_001040259.1	hypothetical protein	-
RK88_RS01075	177977..178351	+	375	WP_000340977.1	hypothetical protein	-
RK88_RS01085	178772..179545	+	774	WP_000750406.1	staphylococcal enterotoxin type A	-
RK88_RS01090	179654..179830	+	177	WP_011447039.1	putative holin-like toxin	Toxin
-	179818..179992	-	175	-	-	Antitoxin
RK88_RS01100	180042..180296	+	255	WP_000611512.1	phage holin	-
RK88_RS01105	180308..181063	+	756	WP_000861038.1	CHAP domain-containing protein	-
RK88_RS01110	181254..181745	+	492	WP_000919350.1	staphylokinase	-
RK88_RS01120	182395..182730	+	336	Protein_207	SH3 domain-containing protein	-
RK88_RS01125	182825..183274	-	450	WP_000727649.1	chemotaxis-inhibiting protein CHIPS	-
RK88_RS01130	183960..184310	+	351	WP_000702263.1	complement inhibitor SCIN-A	-
RK88_RS01135	184363..184623	-	261	WP_001791826.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	groEL / tsst-1 / hlb / sea / sak / chp / scn	116348..184310	67962

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (30-58)

Sequences

Toxin

Protein

• Length: 59 a.a.
• Molecular weight: 6849.45 Da
• Isoelectric Point: 10.6777

>T93097 WP_011447039.1 NZ_CP026071:179654-179830 [Staphylococcus aureus]
MDRWWLSEYKEVVPMVALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSNKK

Nucleotide

• Length: 177 bp

>T93097 NZ_CP026071:179654-179830 [Staphylococcus aureus]
TTGGATAGATGGTGGCTATCTGAGTATAAGGAGGTGGTGCCTATGGTGGCATTACTGAAATCTTTAGAAAGGAGACGCCT
AATGATTACAATTAGTACCATGTTGCAGTTTGGTTTATTCCTTATTGCATTGATAGGTCTAGTAATCAAGCTTATTGAAT
TAAGCAATAAAAAATAA

Antitoxin

Nucleotide

• Length: 175 bp

>AT93097 NZ_CP026071:c179992-179818 [Staphylococcus aureus]
ATTTGATATTTATATTATGGTGTGTTAATTTATATATAGAAAAAGGGCAACATGCGCAAACATGTTACCCTAATGAGCCC
GTTAAAAAGACGGTGGCTATTTTAGATTAAAGATTAAATTAATAACCATTTAACCATCGAAACCAGCCAAAGTTAGCGAT
GGTTATTTTTTATTG

Structures

Toxin

• PDB: 7NS1

Antitoxin