Detailed information of TA system TA093065

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-SprF1/-
• Location: 1463603..1463941
• Replicon: chromosome
• Accession: NZ_CP026069
• Organism: Staphylococcus aureus strain FDAARGOS_25

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: Q2FWU9
• Locus tag: RK83_RS07545
• Protein ID: WP_011447039.1
• Coordinates: 1463603..1463779 (+)
• Length: 59 a.a.

Antitoxin (RNA)

Gene name	SprF1
Locus tag	-
Coordinates	1463767..1463941 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
RK83_RS07525	1461433..1461585	+	153	WP_001000058.1	hypothetical protein	-
RK83_RS07530	1461631..1461918	+	288	WP_001262621.1	hypothetical protein	-
RK83_RS07535	1461974..1462348	+	375	WP_000340977.1	hypothetical protein	-
RK83_RS07540	1462721..1463494	+	774	WP_000750412.1	staphylococcal enterotoxin type A	-
RK83_RS07545	1463603..1463779	+	177	WP_011447039.1	putative holin-like toxin	Toxin
-	1463767..1463941	-	175	-	-	Antitoxin
RK83_RS07555	1463991..1464245	+	255	WP_000611512.1	phage holin	-
RK83_RS07560	1464257..1464988	+	732	WP_000861035.1	CHAP domain-containing protein	-
RK83_RS07565	1465203..1465694	+	492	WP_000920038.1	staphylokinase	-
RK83_RS07585	1466345..1466680	+	336	Protein_1416	SH3 domain-containing protein	-
RK83_RS07590	1467191..1467541	+	351	WP_000702263.1	complement inhibitor SCIN-A	-
RK83_RS07595	1467593..1467853	-	261	WP_001791826.1	hypothetical protein	-
RK83_RS07605	1468164..1468343	-	180	WP_000669791.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	tsst-1 / sec / sell / hlb / sea / sak / scn	1403340..1467541	64201

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (30-58)

Sequences

Toxin

Protein

• Length: 59 a.a.
• Molecular weight: 6849.45 Da
• Isoelectric Point: 10.6777

>T93065 WP_011447039.1 NZ_CP026069:1463603-1463779 [Staphylococcus aureus]
MDRWWLSEYKEVVPMVALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSNKK

Nucleotide

• Length: 177 bp

>T93065 NZ_CP026069:1463603-1463779 [Staphylococcus aureus]
TTGGATAGATGGTGGCTATCTGAGTATAAGGAGGTGGTGCCTATGGTGGCATTACTGAAATCTTTAGAAAGGAGACGCCT
AATGATTACAATTAGTACCATGTTGCAGTTTGGTTTATTCCTTATTGCATTGATAGGTCTAGTAATCAAGCTTATTGAAT
TAAGCAATAAAAAATAA

Antitoxin

Nucleotide

• Length: 175 bp

>AT93065 NZ_CP026069:c1463941-1463767 [Staphylococcus aureus]
ATTTGATATTTATATTATGGTGTGTTAATTTATATATAGAAAAAGGGCAACATGCGCAAACATGTTACCCTAGTGAGCCC
GTTAAAAAGACGGTGGCTATTTTAGATTAAAGATTAAATTAATAACCATTTAACCATCGAAACCAGCCAAAGTTAGCGAT
GGTTATTTTTTATTG

Structures

Toxin

• PDB: 7NS1

Antitoxin